The effect of volatile anesthetics for the myocardial microperfusion in systolic and diastolic phase.

• Project/Area Number: 21791472
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Wakayama Medical University
• Principal Investigator: NEGORO Takaaki 和歌山県立医科大学, 医学部, 助教 (30336896)
• Research Collaborator: NAKAHATA Katsutoshi 和歌山県立医科大学, 医学部, 助教 (70332971)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 揮発性吸入麻酔薬 / 動的心筋内微小潅流 / 動的心筋内微少潅流

Research Abstract

The myocardium that is the muscle of the heart has repeated contraction and relaxation continuously. In order to reveal the action of the volatile anesthetic to the microvessel which supplies blood to the myocardium, we sliced the cardiac muscle of the rat and observed the myocardial microvessel how vessel diameter would change under the influence of vasoactive drugs and volatile anesthetics. Although the capillary vessels in a myocardium showed the contraction under the vasoconstrictor drug, the stable relaxation response by a vasodilator drug was not observed. It was thought that the method of study was unsuitable.