| Project/Area Number |
21791479
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
SAKURABA Shigeki Kanagawa Dental College, 歯学部, 非常勤講師 (00383729)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 筋弛緩薬 / 呼吸中枢 / 呼吸抑制 / 非脱分極性筋弛緩薬 / 中枢性呼吸調節機構 / 血液脳関門 / ベクロニウム / 横隔神経 / アセチルコリン |
|---|
| Research Abstract |
Muscle relaxants used during operation are thought to cause postoperative respiratory depression due to their effects on respiratory muscles. However, in the animal experiment using newborn rats isolated-medulla, muscle relaxants also suppress central respiratory control. Therefore, in this experiment, effects of muscle relaxants injected peripheral vein on central respiratory control were analysed using the in vivo rabbits. Finally, it was found that high dose muscle relaxants suppressed respiratory control also in the in vivo rabbits
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