| Project/Area Number |
21791480
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OOKURA Dan 産業医科大学, 医学部, 研究員 (00596710)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 疼痛管理学 / ナトリウムチャネル / ニューステロイド / 鎮痛作用 / 疼痛機序 / 内因性カンナビノイド / 作用機序 / 新たな鎮痛薬開発 / アフリカツメガエル卵母細胞発現系 / プレグナノロン / アロプレグナノロン / ニューロステロイド / ニユーロステロイド / 麻酔作用 / PS / 疼痛機構 |
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| Research Abstract |
We investigated the effects of analgesics on voltage-gated sodium channels electrophysiologically using Xenopus oocyte expression system to contribute the development of new analgesics for intractable pain. We demonstrated that some neurosteroids and endocannabinoid having analgesic action inhibited some Navα subunits functions, suggesting that this effect is one of the action mechanisms of these analgesics.
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