Study of Antinociceptive Effect of Polyphenols in Rat Experimental Models

Research Project

Project/Area Number	21791481
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Anesthesiology/Resuscitation studies
Research Institution	University of Occupational and Environmental Health, Japan
Principal Investigator	NAKAMURA Motohiro 産業医科大学, 医学部, 助教 (30461578)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	行動薬理学実験 / ポリフェノール / 神経障害性疼痛 / 鎮痛薬 / 動物モデル / 急性疼痛モデル / 疼痛行動実験 / 抗侵害作用 / 腹腔内投与 / 髄腔内投与 / 抗アロディニア作用 / 痛覚過敏
Research Abstract	Several intrathecal polyphenols exerted antinociceptive effect on acute pain. In neuropathic pain model, some drugs attenuated mechanical allodynia but not thermal hyperalgesia, suggesting a weak antinociceptive property.