MicroRNA related gene polymorphisms and its function in urinary tract urothelial carcinoma and renal cell carcinoma

• Project/Area Number: 21791486
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Akita University
• Principal Investigator: HORIKAWA Yohei Akita University, 医学部, 講師 (40361232)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: マイクロRNA / 尿路上皮がん / 腎細胞癌 / 遺伝子多型 / 尿路上皮癌

Research Abstract

We took a polygenic approach to investigate the associations between single nucleotide polymorphisms (SNPs) in miRNA synthesis genes and cancer progression in urinary tract and renal cell carcinoma. We identified several SNPs significantly associations with poor survival in RCC. This result suggests that these miRNA related gene SNPs may modify RCC progression.

Research Products

• [Journal Article] Antitumor effect of sunitinib against skeletal metastatic renal cell carcinoma through inhibition of osteoclast function. (2011)
  • Author(s): Maita S, Yuasa T, Tsuchiya N, Mitobe Y, Narita S, Horikawa Y, et al.
  • Journal Title: Int J Cancer Epub
  • Peer Reviewed
• [Journal Article] Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (2010)
  • Author(s): Lin J, Horikawa Y, Tamboli P, et al
  • Journal Title: Carcinogenesis 31 Pages: 1805-1812
  • Peer Reviewed
• [Journal Article] Two survivin polymorphisms are cooperatively associated with bladder cancer susceptibility. (2010)
  • Author(s): Kawata N, Tsuchiya N, Horikawa Y, et al.
  • Journal Title: Int J Cancer Epub
  • Peer Reviewed
• [Journal Article] Clinical significance of polymorphism and expression of chromogranin A and endothelin-1 in prostate cancer. (2010)
  • Author(s): Ma Z, Tsuchiya N, Yuasa T, Huang M, Obara T, Narita S, Horikawa Y, et al.
  • Journal Title: J Urol 184
  • Peer Reviewed
• [Journal Article] Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (2010)
  • Author(s): Lin J, Horikawa Y., et al.
  • Journal Title: Carcinogenesis Volume: 31 Pages: 1805-12
  • Peer Reviewed
• [Journal Article] The novel tumor-suppressor Mel-18 in prostate cancer :its functional polymorphism, expression and clinical significance. (2009)
  • Author(s): Wang W, Yuasa T, Tsuchiya N, Ma Z, Maita S, Narita S, Kumazawa T, Inoue T, Tsuruta H, Horikawa Y, et al.
  • Journal Title: Int J Cancer 15 Pages: 2836-2843
  • Peer Reviewed
• [Journal Article] Upreguration of HAb18G/CD147 in activated human umbilical vein endothelial cells enhances the angiogenesis. (2009)
  • Author(s): Chen Y, Zhang H, Gou X, Horikawa Y, Xing J, Chen Z.
  • Journal Title: Cancer Lett 278 Pages: 113-121
  • Peer Reviewed
• [Journal Article] The novel tumor-suppressor Mel18 in prostate cancer : its functional polymorphism, expression and clinical significance (2009)
  • Author(s): Wang W, et al.
  • Journal Title: Int J Cancer 125 Pages: 2836-43
  • Peer Reviewed
• [Presentation] Polymorphisms in the XRCC1 and MDM2 genes may be associated with recurrence in non-muscle invasive bladder cancer. (2010)
  • Author(s): Horikawa Y, et al.
  • Organizer: The 106st Annual Meeting of the American Urological Association
  • Place of Presentation: April, Sanfrancisco
• [Presentation] Clinical implications of the MDM2 SNP309 and p53 Arg72Pro polymorphisms in trantitional cell carcinoma of the bladder. (2009)
  • Author(s): Horikawa Y, et al.
  • Organizer: The 105st Annual Meeting of the American Urological Association
  • Place of Presentation: April, Chicago
• [Remarks] ホームページ等