| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Research Abstract |
We initially investigated the effect of subthalamic nucleus deep brain stimulation (STN-DBS) on the micturition reflex, local field potential in the STN, and the levels of catecholamine in the striatum, respectively. STN-DBS significantly inhibit the micturition reflex and increase the power in the . frequency (around 20Hz) in STN. Dopamine metabolites (DOPAC and HVA) in the striatum were slightly increased by STN-DBS without statistically significance. In the next, we generated Parkinson's disease model rat (PD rat) by stereotaxically injecting 6-OHDA into the medial forebrain bundle in normal rat. STN-DBS significantly inhibited micturiton reflex in some PD rats and the power in the . frequency in STN. Striatal DOPAC was significantly decreased by STN-DBS.
This study showed that the effect of STN-DBS was different between normal and PD model rat, which might be important in examining the physiological mechanisms of STN-DBS.
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