Roles of p63 in invasiveness and therapeutic resistance to chemo- and radiotherapy of bladder cancer

• Project/Area Number: 21791490
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: KOGA Fumitaka 東京医科歯科大学, 医学部附属病院, 講師 (10285851)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
• Keywords: 膀胱癌 / 浸潤能 / 化学・放射線療法治療抵抗性 / p63 / 化学・放射線治療抵抗性 / 尿路上皮癌 / p63蛋白

Research Abstract

The main purpose of this study was to investigate a role of p63 in invasive potential of bladder cancer and to clarify its molecular mechanism. We showed that loss of p63 potentiates invasive potential of bladder cancer cells in vitro. We propose its molecular mechanism as follows; increase in N-cadherin expression→increase in recruitment of Shc to N-cadherin→resultant activation of Erk signaling→increase in cell motility and invasiveness.

Research Products

• [Journal Article] Initial Experience of Diffusion-weighted Magnetic Resonance Imaging to Assess Therapeutic Response to Induction Chemoradiotherapy Against Muscle-invasive Bladder Cancer. (2010)
  • Author(s): Yoshida S, Koga F, Kawakami S, Ishii C, Tanaka H, Numao N, Sakai Y, Saito K, Masuda H, Fujii Y, Kihara K.
  • Journal Title: Urology Volume: 75 Pages: 387-391
  • Peer Reviewed
• [Journal Article] Editorial comment to Cancer death from non-muscle invasive bladder cancer: Report of the Japanese Urological Association of data from the 1999-2001 registry in Japan. (2010)
  • Author(s): Koga F.
  • Journal Title: Int J Urol Volume: 17 Pages: 913-913
  • NAID: 10027730565
• [Journal Article] Loss of p63 promotes invasion of urothelial carcinomas. (2010)
  • Author(s): Koga F, Fukushima H, Kawakami S, Fujii Y, Yoshida S,Ratovitski E, Trink B, Kihara K.
  • Journal Title: Eur Urol Suppl Volume: 9 Pages: 291-291
  • Peer Reviewed
• [Journal Article] Partial cystectomy after induction chemoradiotherapy possibly improved oncological outcomes of selective bladder-sparing protocol against muscle-invasive bladder cancer. (2010)
  • Author(s): Koga F, Kihara K, Yoshida S, Saito K, Masuda H, Fujii Y, Kawakami S.
  • Journal Title: Eur Urol Suppl Volume: 9 Pages: 37-38
  • Peer Reviewed
• [Journal Article] Editorial comment to Cancer death from non-muscle invasive bladder cancer : Report of the Japanese Urological Association of data from the 1999-2001 registry in Japan (2010)
  • Author(s): Koga F
  • Journal Title: Int J Urol Volume: 17 Pages: 913-913
  • NAID: 10027730565
• [Journal Article] Initial Experience of Diffusion-weighted Magnetic Resonance Imaging to Assess Therapeutic Response to Induction Chemoradiotherapy Against Muscle-invasive Bladder Cancer (2010)
  • Author(s): Yoshida S, Koga F, Kawakami S, Ishii C, Tanaka H, Numao N, Sakai Y, Saito K, Masuda H, Fujii Y, Kihara K
  • Journal Title: Urology Volume: 75 Pages: 387-391
  • Peer Reviewed
• [Journal Article] Partial cystectomy after induction chemoradiotherapy possibly improves oncological outcomes of selective bladder-sparing protocol against muscle-invasive bladder cancer (2010)
  • Author(s): Koga F, Kihara K, Yoshida S, Saito K, Masuda H, Fujii Y, Kawakami S
  • Journal Title: Eur Urol Suppl Volume: 9 Pages: 37-38
  • Peer Reviewed
• [Journal Article] Loss of p63 promotes invasion of urothelial carcinomas (2010)
  • Author(s): Koga F, Fukushima H, Kawakami S, Fujii Y, Yoshida S, Ratovitski E, Trink B, Kihara K
  • Journal Title: Eur Urol Suppl Volume: 9 Pages: 291-291
  • Peer Reviewed
• [Journal Article] Loss of DeltaNp63alpha promotes invasion of urothelial carcinomas via N-cadherin/Src homology and collagen/extracellular signal-regulated kinase pathway. (2009)
  • Author(s): Fukushima H, Koga F, Kawakami S, Fujii Y, Yoshida S, Ratovitski E, Trink B, Kihara K.
  • Journal Title: Cancer Res Volume: 69 Pages: 9263-9270
  • Peer Reviewed
• [Journal Article] Favourable outcomes of patients with clinical stage T3N0M0 bladder cancer treated with induction low-dose chemo-radiotherapy plus partial or radical cystectomy vs immediate radical cystectomy: a single-institutional retrospective comparative study. (2009)
  • Author(s): Koga F, Kihara K, Fujii Y, Yoshida S, Saito K, Masuda H, Kageyama Y, Kawakami S.
  • Journal Title: BJU Int Volume: 104 Pages: 189-194
  • Peer Reviewed
• [Journal Article] Loss of DeltaNp63alpha promotes invasion of urothelial carcinomas via N-cadherin/Src homology and collagen/extracellular signal-regulated kinase pathway (2009)
  • Author(s): 古賀文隆、福島啓司
  • Journal Title: Cancer Research 69 Pages: 9263-9270
  • Peer Reviewed
• [Presentation] p63の発現消失は尿路上皮癌の浸潤を促進する． (2010)
  • Author(s): 古賀文隆、福島啓司、川上 理、藤井靖久、吉田宗一郎、Edward Ratovitski, Barry Trink, 木原和徳
  • Organizer: 第98回日本泌尿器科学会総会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-04-28
• [Presentation] Loss of p63 promotes invasion of urothelial carcinomas. (2010)
  • Author(s): Koga F, Fukushima H, Kawakami S, Fujii Y, Yoshida S, Ratovitski E, Trink B, Kihara K.
  • Organizer: 25^<th> annual EAU congress
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-04-19
• [Presentation] Loss of p63 promotes invasion of urothelial carcinomas (2010)
  • Author(s): Koga F, Fukushima H, Kawakami S, Fujii Y, Yoshida S, Ratovitski E, Trink B, Kihara K
  • Organizer: 25^<th> annual EAU congress
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-04-19
• [Presentation] Partial cystectomy after induction chemoradiotherapy possibly improved oncological outcomes of selective bladder-sparing protocol against muscle-invasive bladder cancer. (2010)
  • Author(s): Koga F, Kihara K, Yoshida S, Saito K, Masuda H, Fujii Y, Kawakami S.
  • Organizer: 25^<th> annual EAU congress
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-04-17
• [Presentation] Partial cystectomy after induction chemoradiotherapy possibly improves oncological outcomes of selective bladder-sparing protocol against muscle-invasive bladder cancer (2010)
  • Author(s): Koga F, Kihara K, Yoshida S, Saito K, Masuda H, Fujii Y, Kawakami S
  • Organizer: 25^<th> annual EAU congress
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-04-17
• [Presentation] Selective bladder-sparing protocol by induction low-dose chemoradiotherapy plus partial cystectomy against muscle-invasive bladder cancer. (2010)
  • Author(s): Koga F, Kihara K, Yoshida S, Saito K, Masuda H, Fujii Y, Kawakami S.
  • Organizer: 2010 Genitourinary Cancer Sympodium
  • Place of Presentation: San Francisco, USA.
  • Year and Date: 2010-03-06
• [Remarks]
  • URL: http://www.tmd.ac.jp/med/uro/index.htm
• [Remarks]
  • URL: http://www.tmd.ac.jp/med/uro/index.htm