The association of intracellular localization and expression of ATBF1 with the malignant potential of prostate cancer

• Project/Area Number: 21791493
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Niigata University
• Principal Investigator: HARA Noboru 新潟大学, 医歯学総合病院, 助教 (50397113)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 前立腺癌 / ATBF1 / 予後診断 / 内分泌療法 / 分子機構 / アンドロゲン環境 / p21 / p27 / DHEA-S

Research Abstract

Loss of ATBF1 was associated with the high malignant potential in prostate cancer. Processing of ATBF1 may be involved in the alteration of cell cycle markers, which are indices for susceptibility to androgen deprivation. In androgen receptor-active prostate cancer cells, transcription levels of androgen-responsive KLKs were upregulated by adrenal androgens in a concentration-dependent manner. The present study verified that androgen synthesis mediated by the pituitary-adrenal axis is a potential target for advanced ADT.

Research Products

• [Journal Article] Prostate carcinogenesis with diabetes and androgen deprivation therapy-related diabetes : An update (2012)
  • Author(s): Hara N
  • Journal Title: Experimental Diabetes Research Volume: (in press)
• [Journal Article] Deficiency in androgens and upregulation of insulin-like growth factor-1 are involved in high bone turnover in men receiving androgen deprivation therapy for prostate cancer (2012)
  • Author(s): Ishizaki F, Hara N, Takizawa I, Nishiyama T, Isahaya E, Kawasaki T, Takahashi K
  • Journal Title: Growth Hormone & IGF Research
  • URL: http://dx.doi.org/10.1016/j.ghir.2012.04.003
• [Journal Article] Prediction of pathological and oncological outcomes based on extended prostate biopsy results in patients with prostate cancer receiving radical prostatectomy : A single institution study (2012)
  • Author(s): Ishizaki F, Hara N, et al.
  • Journal Title: Diagnostic Pathology
  • URL: http://www.diagnosticpathology.diagnomx.eu/vs/8790262771042628
• [Journal Article] Insulin-like growth factor-1 is associated with regulation of the luteinizing hormone production in men receiving androgen deprivation therapy with gonadotropin-releasing hormone analogues for localized prostate cancer (2012)
  • Author(s): Hara N, Takizawa I, Isahaya E, Nishiyama T, Hoshii T, Ishizaki F, Takahashi K
  • Journal Title: Urologic Oncology : Seminars & Original investigations
  • URL: http://dx.doi.org/10.1016/j.urolonc.2010.11.001
• [Journal Article] Insulin-like growth factor-1 is associated with regulation of the luteinizing hormone production in men receiving androgen deprivation therapy with gonadotropin-releasjng hormone analogues for localized prostate cancer (2012)
  • Author(s): 原昇, 他
  • Journal Title: Urologic Oncology : Seminars and Original Investigations Volume: (In press) Issue: 5 Pages: 596-601
  • DOI: 10.1016/j.urolonc.2010.11.001
  • Peer Reviewed
• [Journal Article] Altered association of interleukin-6 with sex steroids in lipid metabolism disorder in men with prostate cancer receiving androgen deprivation therapy. (2011)
  • Author(s): Komatsu S, Hara N, Ishizaki F, Nishiyama T, Takizawa I, Isahaya E, Kawasaki T, Takahashi K.
  • Journal Title: Prostate Volume: (In press) Issue: 11 Pages: 1207-1213
  • DOI: 10.1002/pros.22471
  • Peer Reviewed
• [Journal Article] External validation of the UCSF-CAPRA(University of California, San Francisco, Cancer of the Prostate Risk Assessment) in Japanese patients receiving radical prostatectomy (2011)
  • Author(s): Ishizaki F, Hoque MA, Nishiyama T, Kawasaki T, Kasahara T, Hara N, Takizawa I, Saito T, Kitamura Y, Akazawa K, Takahashi K
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 41(11) Pages: 1259-64
• [Journal Article] Nephrectomy plus endoscopy-assisted intussusception ureterectomy for patients with renal pelvic cancer : long-term oncological outcomes in comparison with nephroureterectomy plus bladder cuff removal (2011)
  • Author(s): 原昇, 他
  • Journal Title: Journal of Endourology Volume: 25 Issue: 4 Pages: 691-697
  • DOI: 10.1089/end.2010.0336
  • Peer Reviewed
• [Journal Article] Kattan postoperative nomogram for renal cell carcinoma : predictive accuracy in a Japanese population (2011)
  • Author(s): 鈴木一也、西山勉、原昇, 他
  • Journal Title: International Journal of Urology Volume: 18 Issue: 3 Pages: 194-199
  • DOI: 10.1111/j.1442-2042.2010.02693.x
  • NAID: 10030822067
  • Peer Reviewed
• [Journal Article] Clinical feature of men who benefit from dose escalation of naftopidil for lower urinary tract symptoms : a prospective study (2011)
  • Author(s): 水澤隆樹、原昇, 他
  • Journal Title: Advances in Urology Volume: 2011 Pages: 804583-804583
  • DOI: 10.1155/2011/804583
  • Peer Reviewed
• [Journal Article] External Validation of the UCSF-CAPRA (University of California, San Francisco, Cancer of the Prostate Risk Assessment) in Japanese Patients Receiving Radical Prostatectomy (2011)
  • Author(s): Fumio Ishizaki
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 41 Issue: 11 Pages: 1259-1264
  • DOI: 10.1093/jjco/hyr136
  • Peer Reviewed
• [Journal Article] Insulin-like growth fador-1 is associated with regulation of the luteinizing hormone production in men receiving androgen deprivation therapy with gonadotropin-releasing hormone analogues for localized prostate cancer (2011)
  • Author(s): 原昇, 他
  • Journal Title: Urologic Oncology : Seminars and Original Investigations Volume: (In press)
  • Peer Reviewed
• [Journal Article] Adrenocorticotropic hormone is involved in regulation of androgen synthesis in men receiving androgen deprivation therapy for localized prostate cancer (2010)
  • Author(s): Takizawa I, Hara N, Nishiyama T, Isahaya E, Hoshii T, Takahashi K
  • Journal Title: The Journal of Urology Volume: 184(5) Pages: 1971-6
• [Journal Article] Trilostane, an inhibitor of 3β-hydroxysteroid dehydrogenase, has an agonistic activity on androgen receptor in human prostate cancer cells (2010)
  • Author(s): Takizawa I, Nishiyama T, Hara N, Hoshii T, Ishizaki F, Miyashiro Y, Takahashi K
  • Journal Title: Cancer Letter Volume: 297(2) Pages: 226-30
• [Journal Article] Serum prostate-specific antigen levels reflect the androgen milieu in patients with localized prostate cancer receiving androgen deprivation therapy : Tumor malignant potential and androgen milieu (2010)
  • Author(s): Nishiyama T, Hara N, Isahaya E, Hoshii T, Takahashi K
  • Journal Title: Takizawa I, The Prostate Volume: 70(13) Pages: 1395-401
• [Journal Article] Parathyroid hormone-related peptide-producing non-familial pheochromocytoma in a child (2010)
  • Author(s): Takeda K, Hara N, Kawaguchi M, Nishiyama T, Takahashi K
  • Journal Title: International Journal of Urology Volume: 17(7) Pages: 673-6
  • NAID: 10027259471
• [Journal Article] Decline of the red blood cell count in patients receiving androgen deprivation therapy for localized prostate cancer : impact of ADT on insulin-like growth factor-1 and erythropoiesis (2010)
  • Author(s): Hara N, Nishiyama T, Takizawa I, Saito T, Kitamura Y, Takahashi K
  • Journal Title: Urology Volume: 75(6) Pages: 1441-5
• [Journal Article] RE : Decline of the red blood cell count in patients receiving androgen deprivation therapy for localized prostate cancer : impact of ADT on insulin-like growth factor-1 and erythropoiesis (2010)
  • Author(s): Hara N
  • Volume: 76
  • Pages: 1021-1021
• [Journal Article] Bone metabolic disorder in patients with prostate cancer receiving androgen deprivation therapy(ADT): impact of ADT on the growth hormone/insulin-like growth factor-1/parathyroid hormone axis (2010)
  • Author(s): Isahaya E, Hara N, Nishiyama T, Hoshii T, Takizawa I, Takahashi K
  • Journal Title: The Prostate Volume: 70(2) Pages: 155-61
• [Journal Article] Bone metabolic disorder in patients with prostate cancer receiving androgen deprivation therapy (ADT) : impact of ADT on the growth hormone/insulin-like growth factor-1/parathyroid hormone axis. (2010)
  • Author(s): 伊佐早悦子、原昇, 他
  • Journal Title: The Prostate Volume: 70 Pages: 155-161
  • Peer Reviewed
• [Journal Article] Decline of the Red Blood Cell Count in Patients Receiving Androgen Deprivation Therapy for Localized Prostate Cancer : Impact of ADT on Insulin-like Growth Factor-1 and Erythropoiesis. (2010)
  • Author(s): 原昇, 他
  • Journal Title: Urology Volume: 75 Pages: 1441-1445
  • Peer Reviewed
• [Journal Article] Serum prostate-specific antigen levels reflect the androgen milieu in patients with localized prostate cancer receiving androgen deprivation therapy : Tumor malignant potential and androgen milieu. (2010)
  • Author(s): 瀧澤逸大、西山勉、原昇, 他
  • Journal Title: The Prostate Volume: 70 Pages: 1395-1401
  • Peer Reviewed
• [Journal Article] Adrenocorticotropic hormone is involved in regulation of androgen synthesis in men receiving androgen deprivation therapy for localized prostate cancer. (2010)
  • Author(s): 瀧澤逸大、原昇, 他
  • Journal Title: The Journal of Urology Volume: 184 Pages: 1971-1976
  • Peer Reviewed
• [Journal Article] Trilostane, an inhibitor of 3β-hydroxysteroid dehydrogenase, has an agonistic activity on androgen receptor in human prostate cancer cells. (2010)
  • Author(s): 瀧澤逸大、西山勉、原昇, 他
  • Journal Title: Cancer letter Volume: 297 Pages: 226-230
  • Peer Reviewed
• [Journal Article] RE : Decline of the red blood cell count in patients receiving androgen deprivation therapy for localized prostate cancer : impact of ADT on insulin-like growth factor-1 and erythropoiesis (2010)
  • Author(s): 原昇
  • Journal Title: Urology Volume: 76 Pages: 1021-1021
  • Peer Reviewed
• [Journal Article] Parathyroid hormone-related peptide-producing non-familial pheochromocytoma in a child. (2010)
  • Author(s): 武田啓、原昇, 他
  • Journal Title: International Journal of Urology Volume: 17 Pages: 673-676
  • NAID: 10027259471
  • Peer Reviewed
• [Journal Article] Mechanism of acute antibody-mediated rejection in ABO-incompatible kidney transplantation : which anti-A/anti-B antibodies are responsible, natural or de novo? (2010)
  • Author(s): 高橋公太、齊藤和英、中川由紀、田崎正之、原昇, 他
  • Journal Title: Transplantation Volume: 89 Pages: 635-637
  • Peer Reviewed
• [Journal Article] Bone metabolic disorder in patients with prostate cancer receiving androgen deprivation therapy (ADT) : impact of ADT on the growth hormone/insulin-like growth factor-1/parathyroid hormone axis. (2010)
  • Author(s): Isahaya Etsuko
  • Journal Title: The Prostate 70 Pages: 155-161
  • Peer Reviewed
• [Journal Article] Decline of the Red Blood Cell Count in Patients Receiving Androgen Deprivation Therapy for Localized Prostate Cancer : Impact of ADT on Insulin-like Growth Factor-1 and Erythropoiesis.
  • Author(s): Hara Noboru
  • Journal Title: Urology (現在on line)
  • Peer Reviewed
• [Journal Article] Serum prostate-specific antigen levels reflect the androgen milieu in patients with localized prostate cancer receiving androgen deprivation therapy : Tumor malignant potential and androgen milieu.
  • Author(s): Takizawa Itsuhiro
  • Journal Title: The Prostate (in press)
  • Peer Reviewed
• [Presentation] アンドロゲン環境と血清PSA値及びグリーソンスコアとの関連 (2011)
  • Author(s): 原昇
  • Organizer: 第49回日本癌治療学会学術集会
  • Place of Presentation: 名古屋市
  • Year and Date: 2011-10-27
• [Presentation] アンドロゲン環境と血清PSA値及びグリーソンスコアとの関連 (2011)
  • Author(s): 原昇
  • Organizer: 第49回日本癌治療学会学術集会
  • Place of Presentation: 名古屋市(招待講演)
  • Year and Date: 2011-10-27
• [Presentation] Associations Among Anabolic Endocrine Axes in Patients with Prostate Cancer Receiving Androgen Deprivation Therapy (2011)
  • Author(s): 原昇
  • Organizer: 第31回国際泌尿器科学会
  • Place of Presentation: ドイツ,ベルリン
  • Year and Date: 2011-10-18
• [Presentation] Associations Among Anabolic Endocrine Axes in Patients with Prostate Cancer Receiving Androgen Deprivation Therapy (2011)
  • Author(s): 原昇
  • Organizer: 第31回国際泌尿器科学会
  • Place of Presentation: ドイツベルリン
  • Year and Date: 2011-10-18
• [Presentation] アンドロゲン除去療法による骨代謝障害: GH/IGF-1/PTH内分泌軸への影響 (2010)
  • Author(s): 原昇
  • Organizer: 第48回日本癌治療学会
  • Place of Presentation: 京都市
  • Year and Date: 2010-10-28
• [Presentation] アンドロゲン除去療法による骨代謝障害:GH/IGF-1/PTH内分泌軸への影響 (2010)
  • Author(s): 原昇
  • Organizer: 第48回日本癌治療学会
  • Place of Presentation: 京都市
  • Year and Date: 2010-10-28
• [Presentation] アンドロゲン除去療法による骨代謝障害:成長ホルモン/インスリン様成長因子1(IGF-1)/副甲状腺ホルモン内分泌軸への影響 (2010)
  • Author(s): 原昇
  • Organizer: 第98回日本泌尿器科学会総会
  • Place of Presentation: 盛岡市
  • Year and Date: 2010-04-27
• [Presentation] Functional inactivation of insulin-like growth factor-1 in the bone may be relevant to osteoporosis during androgen deprivation therapy (2010)
  • Author(s): 原昇
  • Organizer: 第25回欧州泌尿器科学会
  • Place of Presentation: スペイン,バルセロナ
  • Year and Date: 2010-04-19
• [Presentation] Functional inactivation of insulin-like growth factor-1 in the bone maybe relevant to osteoporosis during androgen deprivation therapy (2010)
  • Author(s): 原昇
  • Organizer: 第25回欧州泌尿器科学会
  • Place of Presentation: スペイン バルセロナ
  • Year and Date: 2010-04-19
• [Presentation] Functional inactivation of insulin-like growth factor-1 in the bone may be relevant to osteoporosis during androgen deprivation therapy (2010)
  • Author(s): 原昇
  • Organizer: 第25回欧州泌尿器科学会
  • Place of Presentation: スペイン バルセロナ
  • Year and Date: 2010-04-19
• [Presentation] Decline of the blood hemoglobin concentration in patients receiving androgen deprivation therapy (ADT) for prostate cancer : Impact of ADT on insulin-like growth factor-1 and erythropoiesis (2009)
  • Author(s): 原昇
  • Organizer: 第30回国際泌尿器科学会
  • Place of Presentation: 上海 中国
  • Year and Date: 2009-11-03
• [Presentation] 膀胱癌における転写因子ATBF1とp21(WAF1/CIP1)の発現:経過と予後の予測における有用性 (2009)
  • Author(s): 原昇
  • Organizer: 第97回日本泌尿器科学会総会
  • Place of Presentation: 岡山
  • Year and Date: 2009-04-16