Comprehensive research on epigenetics in male infertility

• Project/Area Number: 21791496
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Kanazawa University
• Principal Investigator: MAEDA Yuji Kanazawa University, 医学系, 助教 (20377394)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: エピジェネティックス / 精子形成

Research Abstract

The gene expression is selectively controlled. The individuality of the cell is determined by combination of activated genes so that it makes the physiological functions as the entire individual. Epigenetics is taking part as one of the control mechanisms of gene expression. Recent reports showed that epigenetic control is important in embryology or oncology. In mammalian spermatogenesis, spermatogenic cells develop into functional gametes through meiosis with complex gene expression. Our study suggested that certain genes important in spermatogenesis are involved in epigenetic control of its expression.

Research Products

• [Journal Article] Tissue-specific differentially methylated regions of the human VASA gene are potentially associated with maturation arrest phenotype in thetestis. (2009)
  • Author(s): Sugimoto K, Koh E, Sin HS, Maeda Y, Narimoto K, Izumi K, Kobori Y, Kitamura E, Nagase H, Yoshida A, Namiki M.
  • Journal Title: J Hum Genet 54 Pages: 450-456
  • Peer Reviewed
• [Journal Article] Tissue-specific differentially methylated regions of the human VASA gene are potentially associated with maturation arrest phenotype in the testis (2009)
  • Author(s): Kazuhiro Sugimoto, Eitetsu Koh, Ho-Su Sin, Yuji Maeda, Kazutaka Narimoto, Koji Izumi, Yoshitomo Kobori, Eiko Kitamura, Hiroki Nagase, Atsumi Yoshida, Mikio Namiki
  • Journal Title: Journal of Human Genetics 54 Pages: 450-456
  • NAID: 10030731316
  • Peer Reviewed
• [Presentation] ALF gene promoter hypermethylationがTESE-ICSI成績に与える影響 (2009)
  • Author(s): 杉本和宏, 中嶋一史, 中嶋孝夫, 島村正喜, 泉浩二, 成本一隆, 前田雄司, 溝上敦, 高栄哲, 並木幹夫, 吉田淳, 北村栄子, 永瀬浩喜
  • Organizer: 第46回日本生殖医学会北陸支部学術総会
  • Place of Presentation: 金沢ニューグランドホテル(金沢市)
  • Year and Date: 2009-06-07
• [Presentation] Impact ofaberrant ALF gene methylation onoutcome of testicular sperm extractionand intracytoplasmic sperm injection (2009)
  • Author(s): Kazuhiro Sugimoto, Kouji Izumi, Kazutaka Narimoto, Sotaro Miwa, YujiMaeda, Tohru Miyagi, Jiro Kanaya, Yasuhide Kitagawa, Yoshihumi Kadono, Hiroyuki Konaka, Atsushi Mizokami ,Eitetsu Koh, Mikio Namiki
  • Organizer: AUA 2009 Annual Meeting
  • Place of Presentation: Mc Cormick Place West Building(Chicago, IL, USA)
  • Year and Date: 2009-04-27
• [Presentation] TESE-ICSIがDNAメチル化異常による精子形成障害を治療できる可能性 (2009)
  • Author(s): 杉本和宏, 申湖水, 前田雄司, 金谷二郎, 高栄哲, 並木幹夫, 吉田淳, 北村栄子, 永瀬浩喜
  • Organizer: 第97回日本泌尿器科学会総会
  • Place of Presentation: 岡山コンベンションセンター(岡山市)
  • Year and Date: 2009-04-19
• [Presentation] ALF遺伝子にみられるpromoter hypermethylation -エピジェネティック疾患としての精子形成障害の可能性- (2009)
  • Author(s): 杉本和宏, 下田ちはる, 申湖水, 前田雄司, 高栄哲, 並木幹夫, 吉田淳, 北村栄子, 永瀬浩喜
  • Organizer: 第13回北陸泌尿器科BasicResearch Meeting
  • Place of Presentation: ホテル金沢(金沢市)
  • Year and Date: 2009-02-21