Enhanced sensitivity to androgen withdrawal due to overexpression of interleukin-6 in androgen-dependent human prostate cancer LNCaP cells

• Project/Area Number: 21791503
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Kobe University
• Principal Investigator: TERAKAWA Tomoaki Kobe University, 大学院・医学系研究科, 医学研究員 (50533759)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 前立腺癌 / IL-6

Research Abstract

Excessive secretion of IL-6 by LNCaP cells in an autocrine manner may have a suppressive function in their growth and acquisition of androgen-independent phenotype under an androgen-deprived condition.

Research Products

• [Journal Article] Enhanced sensitivity to androgen withdrawal due to overexpression of interleukin-6 in androgen-dependent human prostate cancer LNCaP cells. (2009)
  • Author(s): Terakawa T, Miyake H, Furukawa J, Ettinger SL, Gleave ME, Fujisawa M
  • Journal Title: British Journal of Cancer VOol.101 Pages: 1731-1739
  • Peer Reviewed
• [Journal Article] Enhanced sensitivity to androgen withdrawal due to overexpression of interleukin-6 in androgen-dependent human prostate cancer LNCaP cells (2009)
  • Author(s): Tomoaki Terakawa
  • Journal Title: British Journal of Cancer 101号 Pages: 1731-1739
  • Peer Reviewed
• [Presentation] Enhanced sensitivitytoandrogen withdrawal due to overexpression of Interluekin-6 in androgen-dependent human prostate cancer LNCaP cells (2010)
  • Author(s): 寺川智章
  • Organizer: 第104回アメリカ泌尿器科学会
  • Place of Presentation: サンフランシスコ
  • Year and Date: 2010-06-03
• [Presentation] アンドロゲン依存性前立腺細胞株LNCaPにおけるIL-6高発現の意義 (2010)
  • Author(s): 寺川智章
  • Organizer: 第19回泌尿器分子細胞研究会
  • Place of Presentation: 神戸
  • Year and Date: 2010-02-20
• [Presentation] ENHANCED SENSITIVITY TO ANDROGEN WITHDRAWAL BY OVEREXPRESSION OF INTERLEUKIN-6 IN HUMAN ANDROGEN DEPENDENT PROSTATE CANCER LNCAP CELLS (2009)
  • Author(s): 寺川智章
  • Organizer: 第104回アメリカ泌尿器科学会
  • Place of Presentation: Chicago、(USA)
  • Year and Date: 2009-04-27
• [Presentation] Enhanced sensitivity to androgen withdrawal by overexpression of IL-6 in androgen-dependent prostate cancer LNCaP cells (2008)
  • Author(s): 寺川智章
  • Organizer: 第67回日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] アンドロゲン依存性前立腺細胞株LNCaPにおけるIL-6高発現の意義 (2008)
  • Author(s): 寺川智章
  • Organizer: 第96回日本泌尿器科学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-04-26