Analysis of prostate carcinogenesis using in vitro three-dimensional culture assay
| Project/Area Number |
21791510
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 腫瘍学 / 前立腺癌 / 発癌 / 3次元培養 / 癌 / シグナル伝達 / マイクロアレイ / 前立腺 |
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| Research Abstract |
The mechanism of prostate carcinogenesis is not elucidated yet. In this study, we established a new experimental procedure for analyzing prostate carcinogenesis using in vitro three dimensional culture(3D) assays. Using this method, we showed a direct role for decreased annexin A1 expression in prostate carcinogenesis via the up-regulation of IL-6. Furthermore, we indicated an important role for androgen receptor(AR) in forming normal acinar structure in 3D culture. We reported several mechanisms of prostate carcinogenesis by regulating AR expression and its activity.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Shiota M, Yokomizo A, Masubuchi D, Tada Y, Inokuchi J, Eto M, Uchiumi T, Fujimoto N, Naito S.2010
Author(s)
Shiota M, Yokomizo A, Masubuchi D, Tada Y, Inokuchi J, Eto M, Uchiumi T, Fujimoto N, Naito S.
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Journal Title
Prostate
Volume: 70(5)
Pages: 540-54
Related Report
Peer Reviewed
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