Analysis ofβ2-microglobulin mediated signaling in renal cell carcinoma growth and its bone metastasis

• Project/Area Number: 21791512
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Oita University
• Principal Investigator: NOMURA Takeo 大分大学, 医学部, 講師 (40347034)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 腫瘍学 / b2ミクログロブリン / β2ミクログロブリン

Research Abstract

This study demonstrates for the first time howβ2-microglobulin(β2-M) supports lethal metastasis in vivo in human renal cancer cells(SN12C).β2-M mediates this process by activating epithelial to mesenchymal transition(EMT) to promote lethal bone and soft tissue metastases in host mice. These results demonstrate the role ofβ2-M in renal cancer metastasis and lethality. Thus,β2-M and its downstream signaling pathways are promising prognostic markers of renal cancer metastases and novel therapeutic targets for cancer therapy using anti-β2-M antibody.

Research Products

• [Journal Article] β2-microgloburin induces epithelial to mesenchymal transition and confers cancer lethality and bone metastasis in human cancer cells (2011)
  • Author(s): Josson S, Nomura T, et al
  • Journal Title: Cancer Res Volume: 71 Pages: 2600-2610
• [Journal Article] β2-ミクログロブリンにより腫瘍細胞増殖とその制御 (2011)
  • Author(s): 野村威雄、三股浩光
  • Journal Title: 臨床検査 Volume: 55(1) Pages: 27-35
• [Journal Article] elial to mesenchymal transition and confers cancer lethality and bone met (2011)
  • Author(s): Josson S, Nomura T, et al
  • Journal Title: Cancer Res Volume: 71 Pages: 2600-2610
  • Peer Reviewed
• [Journal Article] b2-ミクログロブリンによる腫瘍細胞増殖とその制御 (2011)
  • Author(s): 野村威雄、三股浩光
  • Journal Title: 臨床検査 Volume: 55 Pages: 27-35
• [Journal Article] β2-microglobulin induces epithelial to mesenchymal transition and confers cancer lethality and bone metastasis in human cancer cells (2011)
  • Author(s): Josson S, Nomura T, et al.
  • Journal Title: Cancer Res Volume: 71 Pages: 2600-2610
  • Peer Reviewed
• [Presentation] Anti-β2-microglobulin antibody is a novel therapeutic agent for human renal cell carcinoma (2011)
  • Author(s): 野村威雄
  • Organizer: Advancements in Urology 2011
  • Place of Presentation: Hawaii
  • Year and Date: 2011-02-17
• [Presentation] Anti-beta2-microglobulin antibody is a novel therapeutic agent for human renal cell carcinoma (2011)
  • Author(s): Takeo Nomura, Wen-Chin Huang, Leland W. K. Chung, Hiromitsu Mimata
  • Organizer: Advancements in Urology
• [Presentation] β2-microglobulin(β2M)シグナル伝達系を標的とした腎細胞癌治療法の検討
  • Author(s): 野村威雄, Leland W. K. Chung, 三股浩光
  • Organizer: 第97回日本泌尿器科学会総会