Analysis ofβ2-microglobulin mediated signaling in renal cell carcinoma growth and its bone metastasis
| Project/Area Number |
21791512
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Oita University |
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Principal Investigator |
NOMURA Takeo 大分大学, 医学部, 講師 (40347034)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 腫瘍学 / b2ミクログロブリン / β2ミクログロブリン |
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| Research Abstract |
This study demonstrates for the first time howβ2-microglobulin(β2-M) supports lethal metastasis in vivo in human renal cancer cells(SN12C).β2-M mediates this process by activating epithelial to mesenchymal transition(EMT) to promote lethal bone and soft tissue metastases in host mice. These results demonstrate the role ofβ2-M in renal cancer metastasis and lethality. Thus,β2-M and its downstream signaling pathways are promising prognostic markers of renal cancer metastases and novel therapeutic targets for cancer therapy using anti-β2-M antibody.
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Report
(4 results)
Research Products
(8 results)
