SNP analysis of SCF-Kit gene in patients with or without OAB

• Project/Area Number: 21791516
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Nagoya City University
• Principal Investigator: KUBOTA Yasue Nagoya City University, 大学院・医学研究科, 講師 (00381830)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 過活動膀胱 / Kit / 間質細胞

Research Abstract

KIT is not only a detection marker of these cells, but also may play a crucial role in the control of bladder function. Research into the effect of c-kit receptor inhibitor, imatinib mesylate, on bladder function implies that KIT-positive ICCs may be therapeutic target cells to reduce bladder overactivity and that the blockage of c-kit receptor may offer a new therapeutic strategy for OAB treatment.

Research Products

• [Journal Article] Correlation between improvements in overactive bladder symptom score and health-related quality of life questionnaires in overactive bladder patients treated with an antimuscarinic drug. (2011)
  • Author(s): Kubota Yasue, Kojima Yoshiyuki, Shibata Yasuhiro, Imura Makoto, Kohri Kenjiro, Sasaki Shoichi.
  • Journal Title: Neurourol Urodyn.
  • Peer Reviewed
• [Journal Article] 臨床医学の展望2011泌尿器科学 排尿障害(尿失禁・神経因性膀胱・過活動膀胱) (2011)
  • Author(s): 窪田泰江
  • Journal Title: 日本医事新報 4530 Pages: 59-60
• [Journal Article] 過活動膀胱患者に対するイミダフェナシンの早期治療効果の検討 (2010)
  • Author(s): 窪田泰江、佐々木昌一、小島祥敬、早瀬麻沙、井村誠、柴田泰宏、郡健二郎
  • Journal Title: 泌尿器外科 23 Pages: 827-832
  • Peer Reviewed
• [Journal Article] 過活動膀胱患者に対するイミダフェナシンの早期治療効果の検討 (2010)
  • Author(s): 窪田泰江, 他
  • Journal Title: 泌尿器外科 Volume: 23(6) Pages: 827-832
  • Peer Reviewed
• [Journal Article] Translational Pharmacology in Aging Men with Benign Prostatic Hyperplasia : Molecular and Clinical Approaches to Alpha1-Adrenoceptors. (2009)
  • Author(s): 小島祥敬、窪田泰江、佐々木昌一, 他
  • Journal Title: Curr Aging Sci. 2 Pages: 223-239
  • Peer Reviewed
• [Journal Article] Mechanical function and gene expression of alpha(1)-adren oceptor subtypes in dog intravesical ureter. (2009)
  • Author(s): 小林伸也、窪田泰江, 他
  • Journal Title: Urology 74 Pages: 458-62
  • Peer Reviewed
• [Journal Article] Correlation between improvements in overactive bladder symptom score and health-related quality of life questionnaires in overactive bladder patients treated with an antimuscarinic drug.
  • Author(s): Yasue Kubota, et al.
  • Journal Title: Neurourol Urodyn. Volume: (In press)
  • Peer Reviewed
• [Presentation] OABSSおよびQOL質問票を用いたOAB患者に対する塩酸プロピベリンの治療効果の検討 (2011)
  • Author(s): 窪田泰江
  • Organizer: 第16回東海排尿障害研究会
  • Place of Presentation: 名古屋市
  • Year and Date: 2011-02-11
• [Presentation] 過活動膀胱患者に対するイミダフェナシンの早期治療効果の検討 (2010)
  • Author(s): 窪田泰江
  • Organizer: わかしゃち泌尿器科セミナー
  • Place of Presentation: 名古屋市
  • Year and Date: 2010-07-14
• [Presentation] A kit ligand, stem cell factor as a possible mediator inducing overactive bladder. (2010)
  • Author(s): Yasue Kubota, et al.
  • Organizer: AUA 2010 Annual Meeting
  • Place of Presentation: Moscone Center, San Francisco, USA
  • Year and Date: 2010-05-30
• [Presentation] Altered distribution of ICC-like cells in the guinea pig bladder following bladder outlet obstruction (2010)
  • Author(s): 窪田泰江
  • Organizer: Smooth Muscle Rhythms-The 6^<th> Inthernational Symposium on ICC-
  • Place of Presentation: シェラトングランデオーシャンリゾート(宮崎県)
  • Year and Date: 2010-02-10
• [Presentation] A kit ligand, stem cell factor as a possible mediator inducing overactive bladder. (2010)
  • Author(s): Kubota Yasue, Kojima Yoshiyuki, Hayase Masa, Sasaki Shoichi, Kohri Kenjiro
  • Organizer: AUA 2010 Annual Meeting
  • Place of Presentation: San Francisco, USA
• [Presentation] Altered distribution of interstitial cells in the guinea pig bladder following bladder outlet obstruction. (2010)
  • Author(s): Kubota Yasue, Kojima Yoshiyuki, Sasaki Shoichi, Hayase Masa, Okada Shinsuke, Kohri Kenjiro
  • Organizer: Smooth Muscle Rhythms -The 6^<th> Inthernational Symposium on ICC-
  • Place of Presentation: Miyazaki, Japan
• [Presentation] 過活動膀胱におけるKit陽性間質細胞の役割 (2009)
  • Author(s): 窪田泰江、小島祥敬、早瀬麻沙、佐々木昌一、橋谷光、鈴木光、郡健二郎
  • Organizer: 第51回日本平滑筋学会総会
  • Place of Presentation: 名古屋市