The role of macrophages for prevention of kidney stone formation
| Project/Area Number |
21791517
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
OKADA Atsushi 名古屋市立大学, 大学院・医学研究科, 助教 (70444966)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 尿路結石 / マクロファージ / op/op / M-CSF / オステオポンチン / グリオキシル酸 / op |
|---|
| Research Abstract |
The present study was performed for investigation of kidney stone prevention effect using M-CSF deficient mice(op/op) and observation of COM crystals phagocytosis using cultured macrophages.
(1) Using op/op mice in which macrophage differentiation and migration cannot occurred by macrophage-colony stimulating factor(M-CSF) gene deficient, increased stone formation were detected. And exogenous M-CSF administration old lead decrease of stone formation.
(2) cells(M-1), COM crystal exposure was performed in vitro. As the results, COM phagocytosis rate of J774.1 were significantly higher than that of M-1.And englobed crystals were detected in the lysosomes in macrophages. Moreover, the crystals were getting reduced during the experiment.
Taken together, the possible function of macrophages for inhibition of kidney stone formation by phagocytosis and processing renal crystals.
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Report
(4 results)
Research Products
(155 results)
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[Journal Article] Mitochondrial permeability transition pore opening induces the initial process of renal calcium crystallization2012
Author(s)
Niimi K, Yasui T, Hirose M, Hamamoto S, Itoh Y, Okada A, Kubota Y, Kojima Y, Tozawa K, Sasaki S, Hayashi Y, Kohri K
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Journal Title
Free Radical Biology & Medicine
Volume: 52
Pages: 1207-1217
Related Report
Peer Reviewed
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[Journal Article] Mitocondrial permeability transition pore opening induces the initial process of renal calcium crystallization2012
Author(s)
Niimi Kazuhiro, Yasui Takahiro, Hirose Masahito, Hamamoto Shuzo, Itoh Yasunori, Okada Atsushi, Kubota Yasue, Kojima Yoshiyuki, Tozawa Keiichi, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro
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Journal Title
Free Radical Biology & Medicine
Volume: 52
Issue: 7
Pages: 1207-1217
DOI
Related Report
Peer Reviewed
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[Journal Article] The role of long-term loading of cholesterol in renal crystal formation2011
Author(s)
Itoh Y, Yoshimura M, Niimi K, Usami M, Hamamoto S, Kobayashi T, Hirose M, Okada A, Yasui T, Tozawa K, Kohri K
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Journal Title
Archivio Italiano di Urologia e Andrologia
Volume: 83
Pages: 23-5
Related Report
Peer Reviewed
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[Journal Article] Crucial role of the cryptic epitope SLAYGLR within osteopontin in renal crystal formation of mice2011
Author(s)
Hamamoto S, Yasui T, Okada A, Hirose M Matsui Y, Kon S, Sakai F, Kojima Y, Hayashi Y, Tozawa K, Ueda T, Kohri K
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Journal Title
Bone and Mineral Research
Volume: 26
Pages: 2967-2977
Related Report
Peer Reviewed
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[Journal Article] The role of long-term loading of cholesterol in renal crystal formation2011
Author(s)
Itoh Yasunori, Yoshimura Mugi, Niimi Kazuhiro, Usami Masayuki, Hamamoto Shuzo, Kobayashi Takahiro, Hirose Masahito, Okada Atsushi, Yasui Takahiro, Tozawa Keiichi, Kohri Kenjiro
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Journal Title
Archivio Italiano di Urologia e Andrologia
Volume: 83
Pages: 23-25
Related Report
Peer Reviewed
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[Journal Article] Crucial role of the cryptic epitope SLAYGLR within osteopontinin renal crystal formation of mice2011
Author(s)
Hamamoto S, Yasui T, Okada A, Hirose M, Matsui Y, Kon S, Sakai F, Kojima Y, Hayashi Y, Tozawa K, Uede T, Ko- hri K
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Journal Title
J Bone Miner Res
Volume: 26
Issue: 12
Pages: 2967-77
DOI
Related Report
Peer Reviewed
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[Journal Article] Renal macrophage migration and crystal phagocytosis via inflammatory-related gene expression during kidney stone formation and elimination in mice : Detection by association analysis of stone-related gene expression and microstructural observation2010
Author(s)
Okada A, Yasui T, Fujii Y, Niimi K, Hamamoto S, Hirose M, Kojima Y, Itoh Y, Tozawa K, Hayashi Y, Kohri K
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Journal Title
Journal of Bone and Mineral Research
Volume: 25
Pages: 2701-2711
Related Report
Peer Reviewed
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[Journal Article] Renal macrophage migration and crystal phagocytosis via inflammatory-related gene expression during kidney stone formation and elimination in mice : Detection by association analysis of stone-related gene expression and microstructural observation.2010
Author(s)
Okada Atsushi, Yasui Takahiro, Fujii Yasuhiro, Niimi Kazuhiro, Hamamoto Shuzo, Hirose Masahito, Kojima Yoshiyuki, Itch Yasunori, Tozawa Keiichi, Hayashi Yutaro, Kohri Kenjiro
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Journal Title
Journal of Bone and Mineral Research
Volume: 25
Pages: 2701-2711
Related Report
Peer Reviewed
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[Journal Article] Embryonal rhabdomyosarcoma of the prostate.2010
Author(s)
Niimi Kazuhiro, Hashimoto Yoshihiro, Kurokawa Satoshi, Okada Atsushi, Tozawa Keiichi, Kohri Kenjiro : Embryonal rhabdomyosarcoma of the prostate. International Journal of Clinical Oncology, 15 : 93-96, 2010
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Journal Title
International Journal of Clinical Oncology
Volume: 15
Pages: 93-96
NAID
Related Report
Peer Reviewed
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[Presentation] Adiponectin is a possible inhibitor for metabolic syndrome induced kidney stone formation using ob/ob mouse2012
Author(s)
Okada Atsushi, Taguchi Kazumi, Hirose Yasuhiko, Niimi Kazuhiro, Fujii Yasuhiro, Kobayashi Takahiro, Usami Masayuki, Hamamoto Shuzo, Hirose Masahito, Itoh Yasunori, Yasui Takahiro, Tozawa Keiichi, Kohri Kenjiro
Organizer
European Association of Urology Annual Congress 2012
Place of Presentation
Le Palais des Congres de Paris(フランス)
Related Report
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[Presentation] M-CSF is a novel preventive agent against renal stone disease by inducing anti-inflammatory macrophages2012
Author(s)
Taguchi Kazumi, Okada Atsushi, Fujii Yasuhiro, Niimi Kazumi, Kobayashi Takahiro, Hamamoto Shuzo, Hirose Masahito, Itoh Yasunori, Yasui Takahiro, Tozawa Keiichi, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro
Organizer
European Association of Urology Annual Congress 2012
Place of Presentation
Le Palais des Congres de Paris(フランス)
Related Report
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[Presentation] Efficacy of cornier official technical training for SWL treatment at the university hospital2012
Author(s)
Hamamoto Shuzo, Okada Atsushi, Taguchi Kazumi, Hirose Yasuhiko, Niimi Kazumi, Fujii Yasuhiro, Ando Ryosuke, Kobayashi Takahiro, Usami Masayuki, Hirose Masahito, Itoh Yasunori, Yasui Takahiro, Tozawa Keiichi, Kohri Kenjiro
Organizer
European Association of Urology Annual Congress 2012
Place of Presentation
Le Palais des Congres de Paris(フランス)
Related Report
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[Presentation] Calcium oxalate crystals could be englobed by macrophages during kidney stone formation in vitro and in vivo models, Renal macrophage migration and crystal phagocytosis via inflammatory-related gene expression during kidney stone formation and elimination2011
Author(s)
Okada A, Taguchi K, Hirose Y, Niimi K, Fujii Y, Kobayashi T, Usami M, Hamamoto S, Hirose M, Itoh Y, Yasui T, Tozawa K, Kohri K, Okada A, Yasui T, Ichikawa J, Nakaoka K, Hirose Y, Taguchi K, Niimi K, Fujii Y, Usami M, Kobayashi T, Ando R, Hamamoto S, Hiros
Organizer
European Association of Urology Annual Congress 2012
Place of Presentation
Paris(France), Washington(U. S. A)
Related Report
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[Presentation] Renal macrophage migration and crystal phagocytosis via inflammatory-related gene expression during kidney stone formation and elimination in mice2011
Author(s)
Okada A, Hamamoto S, Ichikawa J, Nakaoka K, Hirose Y, Taguchi K, Fujii Y, Niimi K, Usami M, Kobayashi T, Hamamoto S, Hirose M, Itoh Y, Yasui T, Tozawa K, Kohri K
Organizer
26th Annual EAU(European Association of Urology) Congress
Place of Presentation
Vienna(Austria)
Related Report
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[Presentation] Hypothetical new aspects of human kidney stone formation ; comparison of clinical and pathological findings of stone-forming and non-stone-forming kidneys2011
Author(s)
Okada A, Nakaoka K, Ichikawa J, Hirose Y, Taguchi K, Niimi K, Fujii Y, Usami M, Kobayashi T, Hamamoto S, Hirose M, Itoh Y, Yasui T, Tozawa K, Kohri K
Organizer
26th Annual EAU(European Association of Urology) Congress
Place of Presentation
Vienna(Austria)
Related Report
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[Presentation] Osteopontin has a crucial role in ultrastructural conversion of calcium oxalate crystals into matrix-involving kidney stones2011
Author(s)
Okada A, Hamamoto S, Ichikawa J, Nakaoka K, Taguchi K, Hirose Y, Fujii Y, Niimi K, Usami M, Kobayashi T, Hirose M, Itoh Y, Yasui T, Tozawa K, Kohri K
Organizer
26th Annual EAU(European Association of Urology) Congress
Place of Presentation
Vienna(Austria)
Related Report
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[Presentation] Renal macrophage migration and crystal phagocytosis via inflammatory-related gene expression during kidney stone formation and elimination in mice2011
Author(s)
Okada Atsushi, Yasui Takahiro, Ichikawa Jun, Nakaoka Kazunori, Hirose Yasuhiko, Taguchi Kazumi, Niimi Kazuhiro, Fujii Yasuhiro, Usami Masayuki, Kobayashi Takahiro, Ando Ryosuke, Hamamoto Shuzo, Hirose Masahito, Itoh Yasunori, Tozawa Keiichi, Kohri Kenjiro
Organizer
American Urological Association Annual Meeting 2011
Place of Presentation
Washington Convention Center (U.S.A)
Related Report
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[Presentation] Pioglitazone, a peroxisome proliferator-activated receptor gamma γ (PPAR-γ) activator, possibly inhibits renal stone formation in rats2011
Author(s)
Taguchi Kazumi, Okada Atsushi, Fujii Yasuhiro, Niimi Kazuhiro, Kobayashi Takahiro, Hamamoto Shuzo, Hirose Masahito, Itoh Yasunori, Yasui Takahiro, Tozawa Keiichi, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro
Organizer
American Urological Association Annual Meeting 2011
Place of Presentation
Washington Convention Center (U.S.A)
Related Report
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[Presentation] Association between urolithiasis and food intake based on data from a Japanese national survey2011
Author(s)
Yasui Takahiro, Okada Atsushi, Taguchi Kazumi, Hirose Yasuhiko, Fujii Yasuhiro, Niimi Kazuhiro, Usami Masayuki, Ando Ryosuke, Hamamoto Shuzo, Kobayashi Takahiro, Hirose Masahito, Itoh Yasunori, Tozawa Keiichi, Kohn Kenjiro
Organizer
American Urological Association Annual Meeting 2011
Place of Presentation
Washington Convention Center (U.S.A)
Related Report
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[Presentation] Macrophage-colony stimulating factor deficient mice demonstrate that macrophages play a defensive role against renal stone formation2011
Author(s)
Taguchi Kazumi, Okada Atsushi, Itoh Yasuhiro, Niimi Kazuhiro, Kobayashi Takahiro, Hamamoto Syuzo, Hirose Masahito, Itoh Yasunori, Yasui Takahiro, Tozawa Keiichi, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro
Organizer
American Urological Association Annual Meeting 2011
Place of Presentation
Washington Convention Center (U.S.A)
Related Report
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[Presentation] Bisphosphonate prevents the recurrence of urolithiasis in postmenopausal woman with osteoporosis2011
Author(s)
Yasui Takahiro, Okada Atsushi, Taguchi Kazumi, Hirose Yasuhiko, Fujii Yasuhiro, Niimi Kazuhiro, Usami Masayuki, Ando Ryosuke, Hamamoto Shuzo, Kobayashi Takahiro, Hirose Masahito, Itoh Yasunori, Tozawa Keiichi, Kohri Kenjiro
Organizer
American Urological Association Annual Meeting 2011
Place of Presentation
Washington Convention Center (U.S.A)
Related Report
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[Presentation] Opening of mitochondrial permeability transition pores induces kidney stone formation2011
Author(s)
Niimi Kazuhiro, Yasui Takahiro, Taguchi Kazumi, Fujii Yasuhiro, Hirose Yasuhiko, Kobayashi Takahiro, Hamamoto Shuzo, Hirose Masahito, Okada Atsushi, Itoh Yasunori, Tozawa Keiichi, Kohri Kenjiro
Organizer
1st Meeting of the EAU Section of Urolithiasis (EULIS)
Place of Presentation
The Mermaid Conference & Events Center(イギリス)
Related Report
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[Presentation] Efficacy of a selective alpha 1A adrenoceptor antagonist as a medical exclusive therapy against ureteral stones2011
Author(s)
Ito Yasunori, Okada Atsushi, Yasui Takahiro, Taguchi Kazumi, Niimi Kazuhiro, Fujii Yasuhiro, Hirose Yasuhiko, Usami Masayuki, Hamamoto Shuzo, Hirose Masahito, Fujita Keiji, Tozawa Keiichi, Kohri Kenjiro
Organizer
1st Meeting of the EAU Section of Urolithiasis (EULIS)
Place of Presentation
The Mermaid Conference & Events Center(イギリス)
Related Report
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[Presentation] Bisphosphonate prevents urolithiasis in men with osteoporosis2011
Author(s)
Yasui Takahiro, Okada Atsushi, Ichikawa Jun, Taguchi Kazumi, Hirose Yasuhiko, Fujii Yasuhiro, Niimi Kazuhiro, Usami Masayuki, Ando Ryosuke, Hamamoto Shuzo, Kobayashi Takahiro, Hirose Masahito, Itoh Yasunori, Tozawa Keiichi, Kohri Kenjiro
Organizer
1st Meeting of the EAU Section of Urolithiasis (EULIS)
Place of Presentation
The Mermaid Conference & Events Center(イギリス)
Related Report
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[Presentation] Calcium oxalate crystals could be englobed by macrophages during kidney stone formation in vitro and in vivo models2011
Author(s)
Fujii Yasuhiro, Okada Atsushi, Ichikawa Jun, Niimi Kazuhiro, Kobayashi Takahiro, Hamamoto Shuzo, Hirose Masahito, Itoh Yasunori, Yasui Takahiro, Tozawa Keiichi, Kohri Kenjiro
Organizer
1st Meeting of the EAU Section of Urolithiasis (EULIS)
Place of Presentation
The Mermaid Conference & Events Center(イギリス)
Related Report
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[Presentation] Osteopontin has a crucial role in ultrastructural conversion of calcium oxalate crystals into matrix-involving kidney stones2010
Author(s)
Okada A, Taguchi K, Nakaoka K, Hirose Y, Fujii Y, Niimi K, Kobayashi T, Hamamoto S, Hirose M, Itoh Y, Yasui T, Tozawa K, Kohri K
Organizer
FASEB Summer Research Conferences ; Osteopontin Biology
Place of Presentation
Steamboat Springs, Colorado, U. S. A.
Related Report
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[Presentation] Osteopontin has a crucial role in ultrastructural conversion of calcium oxalate crystals into matrix-involving kidney stones.2010
Author(s)
Okada Atsushi, Taguchi Kazumi, Nakaoka Kazunori, Hirose Yasuhiro, Kobayashi Takahiro, Hamamoto Shuzo, Hirose Masahito, itoh Yasunori, Yasui Takahiro, Tozawa Keiichi, Kohri Kenjiro
Organizer
FASEB Summer Research Conferences ; Osteopontin Biology
Place of Presentation
Steamboat Grand Resort, Steamboat Springs, Colorado, U.S.A.
Related Report
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[Presentation] Effects of impaired functional domains of osteopontin on renal crystal formation.2010
Author(s)
Hamamoto Shuzo, Yasui Takahiro, Okada Atsushi, Hirose Masahiro, Kobayashi Takahiro, Niimi Kazuhiro, Fujii Yasuhiro, Itch Yasunori, Tozawa Keiichi, Kohri Kenjiro
Organizer
FASEB Summer Research Conferences ; Osteopontin Biology
Place of Presentation
Steamboat Grand Resort, Steamboat Springs, Colorado, U.S.A.
Related Report
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[Presentation] Impact of insulin resistance, serum insulin and adiponectin levels on kidnay stones in Japanese population.2010
Author(s)
Ando Ryosuke, Suzuki Sadao, Nagaya Teruo, Yamada Tamaki, Okada Atsushi, Yasji Takahiro, Tozawa Keiichi, Tokudome Shinkan, Kohri Kenjiro
Organizer
AUA 2010 Annual Meeting
Place of Presentation
MOSCONE CENTER, San Francisco, USA
Related Report
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[Presentation] The role of long-term loading of cholesterol in renal crystal formation.2010
Author(s)
Itoh Yasunori, Niimi Kazuhiro, Usami Masayuki, Kobayashi Takahiro, Hamamoto Shuzo, Hirose Masahito, Okada Atsusi, Yasui Takahiro, Tozawa Keiichi, Kohri Kenjiro
Organizer
AUA 2010 Annual Meeting
Place of Presentation
MOSCONE CENTER, San Francisco, USA
Related Report
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[Presentation] Development of anew method for measuring serum oxalate using a tris(2,2'-bipyridyl)ruthenium(II)chemiluminescence analysis system and importance in urolithiasis patients.2010
Author(s)
Yasui Takahiro, Okada Atsushi, Kobayashi Takabiro, Hirose Masahito, Nakaoka Kazunori, Taguchi Kazumi, Fujii Yasuhiro, Niimi Kazuhiro, Hirose Yasuhiko, Usami Masayuki, Hamamoto Shuzo, Itoh Yasunori, Yamada Yasuyuki, Tozawa Keiichi, Kohri Kenjiro
Organizer
AUA 2010 Annual Meeting
Place of Presentation
MOSCONE CENTER, San Francisco, USA
Related Report
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[Presentation] Genome-wide analysis of genes related to kidney stone formation and elimination in the calcium oxalate nephrolithiasis model mouse : detection of involvement of macrophage activity2009
Author(s)
Okada A, Niimi K, Fujii Y, Kobayashi T, Usami M, Hamamoto S, Hirose M, Yasui T, Tozawa K, Kohri K
Organizer
30th Congress of the Societe International d' Urologie
Place of Presentation
Shanghai, China
Related Report
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[Presentation] Osteopontin has an important role in kidney stone formation and elimination via renal macrophage recruitment and activation2009
Author(s)
Okada A, Tozawa K, Niimi K, Hirose Y, Kobayashi T, Usami M, Hamamoto S, Hirose M, Itoh Y, Yasui T, Hayashi Y, Kohri K
Organizer
AUA 2009 Annual Meeting
Place of Presentation
Chicago(USA)
Related Report
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[Presentation] Osteopontin has an important role in kidney stone formation and elimination via renal macrophage recruitment and activation2009
Author(s)
Okada Atsushi, Tozawa Keiichi, Niimi Kazuhiro, Hirose Yasuhiko, Kobayashi Takahiro, Usami Masayuki, Hamamoto Shuzo, Hirose Masahito, Itoh Yasunori, Yasui Takahiro, Hayashi Yutaro, Kohri Kenjiro
Organizer
American Urological Association Annual Meeting
Place of Presentation
Chicago, USA
Related Report
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[Presentation] Alendronate has a preventive effect on the recurrence of nephrolithiasis by reducing the risk factors of calcium stone.2009
Author(s)
Yasui Takahiro, Okada Atsushi, Usami Masayuki, Hamamoto Shuzo, Kobayashi Takahiro, Hirose Masahito, Itoh Yasunori, Tozawa Keiichi, Hayashi Yutaro, Kohri Kenjiro
Organizer
American Urological Association Annual Meeting
Place of Presentation
Chicago, USA
Related Report
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[Presentation] The role of NF-KB on renal stone formation.2009
Author(s)
Tozawa Keiichi, Yasui Takahiro, Hirose Masahito, Usami Masayuki, Hamamoto Shuzo, Hirose Yasuhiko, Okada Atsushi, Itoh Yasunori, Hayashi Yutaro, Kohri Kenjiro
Organizer
American Urological Association Annual Meeting
Place of Presentation
Chicago, USA
Related Report
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[Presentation] Obesity, metabolic syndrome components and risk of kidney stones in Japanese.2009
Author(s)
Ando Ryosuke, Suzuki Sadao, Yamada Tamaki, Kobayashi Takahiro, Okada Atsushi, Itoh Yasunori, Yasui Takahiro, Tozawa Keiichi, Tokudome Shinkan, Kohri Kenjiro
Organizer
6th eLURIS Symposium (13th European Symposium on Urolighiasis)
Place of Presentation
Como(Italy)
Related Report
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[Presentation] The role of NF-κB on renal stone formation : possibility of the prevention of urinary stone formation using antinf-κb reagent, N-Acetyl-L-Cysteine.2009
Author(s)
Tozawa Keiichi, Okada Atsushi, Yasui Takahiro, Gao Bing, Ito Yasunori, Hirose Masahito, Usami Masayuki, Hamamoto Syuzo, Kohri Kenjiro
Organizer
30th Congress of the Societe Internationald' Urologie
Place of Presentation
Shanghai, China
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