Mechanism of urinary stone formation approach by PPAR agonists and metabolic syndrome.
| Project/Area Number |
21791522
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
KOBAYASHI Takahiro Nagoya City University, 大学院・医学研究科, 研究員 (90534743)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 尿路結石 / メタボリックシンドローム / 高脂肪食 / 脂質代謝改善薬 / PPARγ |
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| Research Abstract |
In lithiasis model rats, urolithiasis suppressant effect was accepted from control group in the PPARγ administrated group. Tthe expression of gene OPN, MCP1 and CD68 decreased, and the expression of the SOD rose. The difference was not seen in quantity of excretion citrate and urinary oxalic acid.
It was concern that PPARγ agonist reduced urolithiasis by antioxisidant action.
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Report
(3 results)
Research Products
(30 results)
