Analysis of the association between the polymorphism of the oxidative stress related gene and prostate carcinogenesis : an autopsy study

• Project/Area Number: 21791524
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Osaka City University
• Principal Investigator: IGUCHI Taro Osaka City University, 大学院・医学研究科, 講師 (80529206)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 腫瘍学 / 前立腺潜在癌 / 遺伝子多型 / 酸化ストレス / 前立腺癌 / 参加ストレス

Research Abstract

The predictive OR of MnSOD AA for significant versus insignificant cancers was 5.04 (sensitivity=0.58; positive predictive value=0.79) in men >70 years old. MnSOD polymorphism is strongly associated with the clinical significance of prostate cancer suggesting that oxidative stress may be involved in the progression of the disease. MnSOD may be a clinically useful marker to predict the potential of progression from clinically insignificant to significant cancers.

Research Products

• [Journal Article] A Case of Scrotal Neurofibroma Originated from Subcutaneous Neural Tissue. (2010)
  • Author(s): Shibano S, Iguchi T, Nakatani T.
  • Journal Title: Int J Urol 17(4) Pages: 387-388
  • NAID: 10027258121
  • Peer Reviewed
• [Journal Article] Investigation of Chronic Kidney Disease in Benign Prostatic Hyperplasia (2010)
  • Author(s): Yamasaki T, Naganuma T, Iguchi T, et al.
  • Journal Title: Nephron 16(3) Pages: 335-339
  • Peer Reviewed
• [Journal Article] Association between chronic kidney disease and small residual urine volumes in patients with benign prostatic hyperplasia. (2010)
  • Author(s): Takeshi Yamasaki
  • Journal Title: Nephrology Volume: 16(3) Pages: 335-9
  • Peer Reviewed
• [Journal Article] MnSOD genotype and prostate cancer risk as a function of NAT genotype and smoking status (2009)
  • Author(s): Iguchi T, Sugita S, Wang C, et al.
  • Journal Title: in vivo 23(1) Pages: 7-12
  • Peer Reviewed
• [Journal Article] MnSOD Genotype and Prostate Cancer Risk as a Function of NAT Genotype and Smoking Status (2009)
  • Author(s): TARO IGUCHI
  • Journal Title: In vivo 23 Pages: 7-12
  • Peer Reviewed
• [Presentation] Pathological Characteristics and Manganese Superoxide Dismutase Genetic Polymorphism of Prostate Cancer in Men 70 Years or Older : An Autopsy Study (2010)
  • Author(s): Taro Iguchi
  • Organizer: American Urological Association Annual Meeting 2010
  • Place of Presentation: San Francisco, CA USA
  • Year and Date: 2010-05-30
• [Presentation] 前立腺癌悪性度とMnSODの遺伝子多型の検討 (2010)
  • Author(s): 井口太郎, Delongchamps N, Wang C, et al.
  • Organizer: 第98回日本泌尿器科学会総会
  • Place of Presentation: 岩手,日本
  • Year and Date: 2010-04-27
• [Presentation] Edaravone, a radical scavenger, inhibits cisplatin-induced acute renal injury and chronic renal cyst formation by protecting renal mitochondria. (2010)
  • Author(s): Iguchi T, Nishikawa M, Inoue M, et al.
  • Organizer: European Association of Urology Annual Congress 2010
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-04-19
• [Presentation] Edaravone, a radical scavenger, inhibits cisplatin-induced acute renal injury and chronic renal cyst formation by protecting renal mitochondria (2010)
  • Author(s): Taro Iguchi
  • Organizer: European Association of Urology Annual Congress 2010
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-04-19
• [Presentation] Pathological characteristics and manganese superoxide dismutase genetic polymorphism of prostate cancer in men 70 years or older : an autopsy study. (2009)
  • Author(s): Iguchi T, Delongchamps N, Wang C, et al.
  • Organizer: 5th APSSAM Osaka Conference.
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2009-10-19
• [Presentation] Pathological characteristics and manganese superoxide dismutase genetic polymorphism of prostate cancer in men 70 years or older : an autopsy study (2009)
  • Author(s): Taro Iguchi
  • Organizer: APSSAM 2009
  • Place of Presentation: Osaka, JAPAN
  • Year and Date: 2009-10-17
• [Presentation] Role of NF-κB in bladder carcinogenesis in the rat. (2009)
  • Author(s): Wang C, Imaida K, Iguchi T, et al.
  • Organizer: Northeastern Section AUA 61st Annual Meeting
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2009-10-08
• [Presentation] Role of NF-κB in bladder carcinogenesis in the rat (2009)
  • Author(s): Ching Y Wang
  • Organizer: Northeastern Section of the AUA 2009
  • Place of Presentation: Montreal, CANADA
  • Year and Date: 2009-10-08
• [Presentation] Pathological Characteristics and Manganese Superoxide Dismutase Genetic Polymorphism of Prostate Cancer in Men 70 Years or Older : An Autopsy Study. (2009)
  • Author(s): Iguchi T, Delongchamps N, Wang C, et al.
  • Organizer: American Urological Association Annual Meeting 2010
  • Place of Presentation: San Francisco, CA USA
  • Year and Date: 2009-05-30
• [Presentation] Pathological characteristics of prostate cancer in men 70 years or older : an autopsy study. (2009)
  • Author(s): Delongchamps N, Iguchi T, Wang C, et al.
  • Organizer: American Urological Association Annual Meeting 2009
  • Place of Presentation: Chicago, IL USA
  • Year and Date: 2009-04-26
• [Presentation] Pathological characteristics of prostate cancer in men 70 years or older : an autopsy study (2009)
  • Author(s): Nicolas B Delongchamps
  • Organizer: American Urological Association Annual Meeting 2009
  • Place of Presentation: Chicago, IL USA
  • Year and Date: 2009-04-26
• [Presentation] Role of NF-κB in bladder carcinogenesis in the rat. (2009)
  • Author(s): Wang C, Imaida K, Iguchi T, et al.
  • Organizer: AACR 100th Annual Meeting 2009
  • Place of Presentation: Denver, CO USA
  • Year and Date: 2009-04-19
• [Presentation] Role of NF-κB in bladaer carcinogenesis in the rat (2009)
  • Author(s): Ching Y Wang
  • Organizer: AACR 100th Annual Meeting
  • Place of Presentation: Denver, CO USA
  • Year and Date: 2009-04-19
• [Book] Abdominal Masses, The 5-Minute Urology Consult, 2nd edition(ed.Leonard G.Gomella, MD) (2009)
  • Author(s): Iguchi T, Haas GP.
  • Publisher: Lippincott Williams & Wilkins