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The effect of TS-1 and enhanced chemosensitivity to TS-1 by rTS gene therapy in bladder cancer.

Research Project

Project/Area Number 21791529
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionKeio University

Principal Investigator

IDE Hiroki  Keio University, 医学部, 助教 (70365360)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords膀胱癌 / 化学療法 / 遺伝子治療
Research Abstract

This experiments revealed that the treatment with TS-1 resulted in a significantly higher level of growth inhibition compared to that with other 5-FU-based agent in bladder cancer cell lines with a higher level of DPD. Furthermore, our study showed that bladder cancer cells with higher TS or DPD have lower sensitivity of 5-FU and bladder cancer cells in which the levels of TS and DPD were down-regulated using siRNA had higher sensitivity of 5-FU. Thus, these results indicated that elevated TS and DPD levels were strongly associated with decreased sensitivity of 5-FU in bladder cancer.
The present study showed that the treatment of TS-1 in combination with CPT-11 that was able to down-regulate the level of TS resulted in a significantly higher level of growth inhibition compared to that with TS-1 alone or CPT-11 alone. Thus, from these results, the combination treatment of TS-1 in combination with rTS gene therapy in which the level of TS was able to be down-regulated might be a novel treatment against bladder cancer.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (10 results)

All 2010 2009 Other

All Presentation (9 results) Remarks (1 results)

  • [Presentation] Novel therapeutic modality of S-1 in combination with CPT-11 to overcome 5-fluorouracil resistance in bladder cancer.2010

    • Author(s)
      Hiroki Ide, Eiji Kikuchi, Yota Yasumizu, Seiya Hattori, Masanori Hasegawa, Akira Miyajima, Mototsugu Oya.
    • Organizer
      The 106^<th> annual meeting of American Urological Association.
    • Place of Presentation
      San Francisco, USA.
    • Year and Date
      2010-05-31
    • Related Report
      2010 Final Research Report
  • [Presentation] Novel therapeutic modality of S-1 in combination with CPT-11 to overcome 5-fluorouracil resistance in bladder cancer.2010

    • Author(s)
      Hiroki Ide, Eiji Kikuchi, et al.
    • Organizer
      2010 American Urological Association Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2010-05-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] 膀胱腫瘍に対するS-1・CPT-11併用による殺細胞効果の検討2010

    • Author(s)
      井手広樹、菊地栄次、服部盛也、安水洋太、長谷川政徳、宮嶋哲、大家基嗣
    • Organizer
      第98回日本泌尿器科学会総会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-04-27
    • Related Report
      2010 Final Research Report
  • [Presentation] 膀胱腫瘍に対するS-1・CPT-11併用による殺細胞効果の検討2010

    • Author(s)
      井手広樹、菊地栄次, 他
    • Organizer
      第98回日本泌尿器科学会
    • Place of Presentation
      岩手県盛岡市
    • Year and Date
      2010-04-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] The combination treatment of S-1 with CPT-11 to overcome 5-fluorouracil resistance in bladder cancer.2010

    • Author(s)
      井手広樹、菊地栄次, 他
    • Organizer
      第8回APOS(Asia Pacific Oncology Summit)
    • Place of Presentation
      東京
    • Year and Date
      2010-03-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 膀胱腫瘍に対するS-1・CPT-11併用による殺細胞効果の検討2010

    • Author(s)
      井手広樹、菊地栄次, 他
    • Organizer
      第19回泌尿器科分子・細胞研究会
    • Place of Presentation
      神戸
    • Year and Date
      2010-02-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] The combination treatment of S-1 with CPT-11 in bladder cancer.2009

    • Author(s)
      Hiroki Ide, Eiji Kikuchi, Yota Yasumizu, Seiya Hattori, Masanori Hasegawa, Akira Miyajima, Mototsugu Oya.
    • Organizer
      第68回癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
    • Related Report
      2010 Final Research Report
  • [Presentation] The combination treatment of S-1 with CPT-11 in bladder cancer.2009

    • Author(s)
      井手広樹、菊地栄次, 他
    • Organizer
      第68回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 膀胱腫瘍に対する5-FU・ギメラシル併用による殺細胞効果の検討2009

    • Author(s)
      井手広樹、菊地栄次, 他
    • Organizer
      第13回日本がん分子標的治療学会
    • Place of Presentation
      徳島
    • Year and Date
      2009-06-26
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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