Analysis of function and the target genes of micro-RNAs in prostate cancer
| Project/Area Number |
21791530
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Teikyo University |
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Principal Investigator |
KOJIMA Satoko Teikyo University, 医学部, 准教授 (10345019)
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| Co-Investigator(Renkei-kenkyūsha) |
SEKI Naohiko 千葉大学, 大学院・医学研究院, 准教授 (50345013)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 前立腺癌 / マイクロRNA / アポトーシス / 標的遺伝子解析 / 発現プロファイル / PC3 / 細胞増殖 |
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| Research Abstract |
The mechanism of progression of cancer (PCa) to androgen-independent (AI) stage has not completely known. MicroRNAs (miRNAs) are known to have important roles in cancer development and malignant transformation. It is well known that miR-15a and miR-16-1 functions as tumor suppressor in lymphomas. We previously revealed that miR-15a caused growth inhibition and induced apoptosis in prostate cancer cells. In this study, we identified several miRNAs those were differentially expressed in PCa based on genome-wide miRNA expression signature. Analysis of the target genes may have therapeutic implications and may be exploited for future treatment of advanced PCa.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Mir-96 and miR-183 detection in urine serve as potential tumor markers of urothelial carcinoma : correlation with stage and grade, and comparison with urinary cytology.2011
Author(s)
Yasutoshi Yamada, Hideki Enokida, Satoko Kojima, Kazumori Kawakami, Takeshi Chiyomaru, Shuichi Tatarano, Hirofumi Yoshino, Kazuya Kawahara, Kenryu Nishiyama, Naohiko Seki, Masayuki Nakagawa.
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Journal Title
Cancer Sci 102(3)
Pages: 522-529
NAID
Related Report
Peer Reviewed
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[Journal Article] Restoration of miR-145 expression suppresses cell proliferation, migration and invasion in prostate cancer by targeting FSCN1.2011
Author(s)
Miki Fuse, Nijiro Nohata, Satoko Kojima, Shinichi Sakamoto, Takeshi Chiyomaru, Kazumori Kawakami, Hideki Enokida, Masayuki Nakagawa, Yukio Naya, Tomohiko Ichikawa, Naohiko Seki.
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Journal Title
Int.J.Oncol. 38
Pages: 1093-1011
Related Report
Peer Reviewed
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[Presentation]2009
Author(s)
Satoko Kojima, Ryoko Watanabe, Jun Tsukada, Yuzo Furuya, Naohiko Seki.
Organizer
The 100^<th> AUA annual meeting MiR-15a functions as a tumor suppressor for prostate cancer by targeting multiple oncogenes.
Place of Presentation
Chicago, Illinois, USA.
Related Report
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