| Project/Area Number |
21791530
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Teikyo University |
|---|
Principal Investigator |
KOJIMA Satoko Teikyo University, 医学部, 准教授 (10345019)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SEKI Naohiko 千葉大学, 大学院・医学研究院, 准教授 (50345013)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | 前立腺癌 / マイクロRNA / アポトーシス / 標的遺伝子解析 / 発現プロファイル / PC3 / 細胞増殖 |
|---|
| Research Abstract |
The mechanism of progression of cancer (PCa) to androgen-independent (AI) stage has not completely known. MicroRNAs (miRNAs) are known to have important roles in cancer development and malignant transformation. It is well known that miR-15a and miR-16-1 functions as tumor suppressor in lymphomas. We previously revealed that miR-15a caused growth inhibition and induced apoptosis in prostate cancer cells. In this study, we identified several miRNAs those were differentially expressed in PCa based on genome-wide miRNA expression signature. Analysis of the target genes may have therapeutic implications and may be exploited for future treatment of advanced PCa.
|
