Functions of endometrial and circulating NK cells for achievement and maintenance of pregnancy
| Project/Area Number |
21791536
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Hirosaki University |
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Principal Investigator |
FUKUI Atsushi 弘前大学, 医学部・附属病院, 講師 (00321969)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 生殖医学 / NK細胞 / Natural Cytotoxicity Receptor / サイトカイン / 子宮内膜 / 脱落膜 / 妊娠高血圧症候群 / Natural Cytotoxicity Receptor (NCR) / Recurrent Pregnancy Loss (RPL) / 着床不全 / Natural Cytotoxicity Receptor(NCR) / Recurrent Pregnancy Loss(RPL) |
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| Research Abstract |
I evaluated the function of NK cells for achievement and maintenance of pregnancy using pregnant and non-pregnant peripheral blood NK cells and non-pregnant endometrial NK cells. The abnormal expression of natural cytotoxicity receptors (NCRs), especially NKp46 on NK cell is associated with reproductive failures. The abnormal cytokines production by NK cells exists in reproductive failures. There is a direct correlation between the expression of NKp46 on NK cell and cytokines production by NK cells.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Changes of NK cells in preeclampsia2012
Author(s)
Fukui A, Yokota M, Funamizu A, Nakamua R, Fukuhara R, Yamada K, Kimura H, Fukuyama A, Kamoi M, Tanaka K, Mizunuma H
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Journal Title
American journal of reproductive immunology
Volume: 67
Pages: 278-286
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[Journal Article] Fluctuation of peripheral blood T, B, and NK cells during a menstrual cycle of normal healthy women2010
Author(s)
Lee S, Kim J, Jang B, Hur S, Jung U, Kil K, Na B, Lee M, Choi Y, Fukui A, Gilman-Sachs A, Kwak-Kim JY
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Journal Title
J Immunol
Volume: 185
Pages: 756-762
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