Functions of endometrial and circulating NK cells for achievement and maintenance of pregnancy

• Project/Area Number: 21791536
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Hirosaki University
• Principal Investigator: FUKUI Atsushi 弘前大学, 医学部・附属病院, 講師 (00321969)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 生殖医学 / NK細胞 / Natural Cytotoxicity Receptor / サイトカイン / 子宮内膜 / 脱落膜 / 妊娠高血圧症候群 / Natural Cytotoxicity Receptor (NCR) / Recurrent Pregnancy Loss (RPL) / 着床不全 / Natural Cytotoxicity Receptor(NCR) / Recurrent Pregnancy Loss(RPL)

Research Abstract

I evaluated the function of NK cells for achievement and maintenance of pregnancy using pregnant and non-pregnant peripheral blood NK cells and non-pregnant endometrial NK cells. The abnormal expression of natural cytotoxicity receptors (NCRs), especially NKp46 on NK cell is associated with reproductive failures. The abnormal cytokines production by NK cells exists in reproductive failures. There is a direct correlation between the expression of NKp46 on NK cell and cytokines production by NK cells.

Research Products

• [Journal Article] Changes of NK cells in preeclampsia (2012)
  • Author(s): Fukui A, Yokota M, Funamizu A, Nakamua R, Fukuhara R, Yamada K, Kimura H, Fukuyama A, Kamoi M, Tanaka K, Mizunuma H
  • Journal Title: American journal of reproductive immunology Volume: 67 Pages: 278-286
• [Journal Article] Changes of NK cells in preeclampsia (2012)
  • Author(s): Atsushi Fukui
  • Journal Title: America Journal of Reproductive Immunology Volume: 67 Issue: 4 Pages: 278-286
  • DOI: 10.1111/j.1600-0897.2012.01120.x
  • Peer Reviewed
• [Journal Article] 流産の原因と対策免疫機構から見た流産の病態解明とその対策 (2011)
  • Author(s): 福井淳史
  • Journal Title: 日本産科婦人科学会雑誌 Volume: 63 Pages: 337-338
• [Journal Article] 妊娠の成立と維持におけるNK細胞の機能分担と機能発現 (2011)
  • Author(s): 福井淳史
  • Journal Title: 北海道産科婦人科学会会誌 Volume: 55 Pages: 79-84
  • NAID: 130008049645
• [Journal Article] Foxp3(high) and Foxp3(low) Treg cells differentially correlatewith T helper 1 and natural killer cells in peripheral blood (2011)
  • Author(s): Lee SK, Kim JY, Jang BW, Hur SE, Na BJ, Lee M, Fukui A, Gilman-Sachs A, Kwak-Kim J
  • Journal Title: Hum Immunol Volume: 72 Pages: 621-626
• [Journal Article] Uterine and circulating natural killer cells and their roles in women with recurrent pregnancy loss, implantation failure and preeclampsia (2011)
  • Author(s): Fukui A, Funamizu A, Yokota M, Yamada K, Nakamua R, Fukuhara R, Kimura H, Mizunuma H
  • Journal Title: J Reprod Immunol Volume: 90 Pages: 105-110
• [Journal Article] Uterine and circulating natural killer cells and their roles in women with recurrent pregnancy loss, implantation failures and preeclampsia (2011)
  • Author(s): Atsushi Fukui
  • Journal Title: Journal of reproductive immunology Volume: 90 Pages: 105-110
  • Peer Reviewed
• [Journal Article] Foxp3^<high> and Foxp3^<low> Treg cells differentially correlate with T helper 1 and natural killer cells in peripheral blood (2011)
  • Author(s): Sung-Ki Lee
  • Journal Title: Human Immunology Volume: 72 Pages: 621-626
  • Peer Reviewed
• [Journal Article] 免疫機構から見た流産の病態解明とその対策 (2011)
  • Author(s): 福井淳史
  • Journal Title: 日本産科婦人科学会雑誌 Volume: 63 Pages: 2167-2184
  • NAID: 110008799036
  • Peer Reviewed
• [Journal Article] 黄体中期子宮内膜および流産脱落膜Natural Killer細胞におけるNatural Cytotoxicity Receptors発現 (2010)
  • Author(s): 福井淳史, 中村理果, 山田健市, 横田恵, 福原理恵, 木村秀崇, 藤井俊策, 水沼英樹
  • Journal Title: 日本受精着床学会雑誌 Volume: 27 Pages: 369-374
  • NAID: 10027212049
• [Journal Article] 妊娠高血圧症候群発症へのNK細胞Natural Cytotoxicity ReceptorとNK細胞産生サイトカインの関与 (2010)
  • Author(s): 福井淳史, 福原理恵, 木村秀崇, 山本善光, 田中幹二, 尾崎浩士, 水沼英樹
  • Journal Title: 日本妊娠高血圧学会雑誌 Volume: 18 Pages: 173-174
• [Journal Article] NK cell and its role in reproduction (2010)
  • Author(s): Fukui A
  • Journal Title: Am J Reprod Immunol Volume: 64 Pages: 1-2
• [Journal Article] Fluctuation of peripheral blood T, B, and NK cells during a menstrual cycle of normal healthy women (2010)
  • Author(s): Lee S, Kim J, Jang B, Hur S, Jung U, Kil K, Na B, Lee M, Choi Y, Fukui A, Gilman-Sachs A, Kwak-Kim JY
  • Journal Title: J Immunol Volume: 185 Pages: 756-762
• [Journal Article] Fluctuation of Peripheral Blood T, B, and NK Cells during a Menstrual Cycle of Normal Healthy Women (2010)
  • Author(s): Sungki Lee
  • Journal Title: The Journal of Immunology Volume: 185 Pages: 756-762
  • Peer Reviewed
• [Journal Article] 妊娠高血圧症候群発症へのNK細胞Natural Cytotoxicity ReceptosとNK細胞産生サイトカインの関与 (2010)
  • Author(s): 福井淳史
  • Journal Title: 日本妊娠高血圧学会雑誌 Volume: 18 Pages: 173-174
  • Peer Reviewed
• [Journal Article] 黄体中期子宮内膜および流産脱落膜 Natural Killer 細胞における Natural Cytotoxicity Receptors 発現 (2010)
  • Author(s): 福井淳史
  • Journal Title: 日本受精着床学会雑誌 27 Pages: 369-374
  • NAID: 10027212049
  • Peer Reviewed
• [Journal Article] Correlation between natural cytotoxicity receptors and intracellular cytokine expression of peripheral blood NK cells in women with recurrent pregnancy losses and implantation failures (2009)
  • Author(s): Fukui A, Ntrivalas E, Fukuhara R, Fujii S, Mizunuma H, Gilman-Sachs A, Beaman K, Kwak-Kim J
  • Journal Title: Am J Reprod Immunol Volume: 62 Pages: 371-380
• [Journal Article] 【生殖と免疫をめぐって】受精卵着床不全におけるNK細胞の役割 (2009)
  • Author(s): 福井淳史, 福原理恵, 木村秀崇, 藤井俊策, 水沼英樹
  • Journal Title: 臨床免疫・アレルギー科 Volume: 52 Pages: 158-165
• [Journal Article] 着床不全症例におけるNK細胞上Natural Cytotoxicity Receptors発現とNK細胞産生サイトカイン (2009)
  • Author(s): 福井淳史, 中村理果, 山田健市, 福原理恵, 木村秀崇, 藤井俊策, 水沼英樹
  • Journal Title: 日本受精着床学会雑誌 Volume: 26 Pages: 341-347
• [Journal Article] Correlation Between Natural Cytotoxicity Receptors and Intra- cellular Cytokine Expression of Peripheral Blood NK Cells in Women with Recurrent Pregnancy Losses and Implantation Failures (2009)
  • Author(s): 福井淳史
  • Journal Title: American Jounal of Reproductive Immunology 62 Pages: 371-380
  • Peer Reviewed
• [Journal Article] 受精卵着床不全におけるNK細胞の役割 (2009)
  • Author(s): 福井淳史
  • Journal Title: 臨床免疫・アレルギー科 52 Pages: 158-165
• [Presentation] Changes in NK cells functions in normal pregnancy and preeclampsia (2011)
  • Author(s): Atsushi Fukui
  • Organizer: First Clinical Reproductive Immunology Symposium
  • Place of Presentation: Providence, RI, USA
  • Year and Date: 2011-11-19
• [Presentation] Uterine and circulating natural killer cells and their roles in women with recurrent pregnancy losses, implantation failures or preeclampsia (2011)
  • Author(s): Atsushi Fukui
  • Organizer: European Society for Reproductive Immunology
  • Place of Presentation: Munich, Germany
  • Year and Date: 2011-11-13
• [Presentation] 妊娠の成立・維持におけるNK細胞の機能 (2011)
  • Author(s): 福井淳史
  • Organizer: 日本胎盤学会
  • Place of Presentation: 東京都
  • Year and Date: 2011-09-30
• [Presentation] 免疫機構から見た流産の病態解明とその対策 (2011)
  • Author(s): 福井淳史
  • Organizer: 日本産科婦人科学会
  • Place of Presentation: 大阪市
  • Year and Date: 2011-08-28
• [Presentation] Changes of NK cells in preeclampsia (2011)
  • Author(s): Atsushi Fukui
  • Organizer: American societyl of reproductive immunology
  • Place of Presentation: Salt Lake City, UT, USA
  • Year and Date: 2011-05-20
• [Presentation] The expression of NK cell receptors and cytokines production on endometrial or decidual natural killer cells in women with recurrent pregnancy loss (2011)
  • Author(s): Atsushi Fukui
  • Organizer: American Society for Reproductive Immunology
  • Place of Presentation: Salt Lake City, UT, USA
• [Presentation] 免疫機構から見た流産の病態解明とその対策 (2011)
  • Author(s): 福井淳史
  • Organizer: 日本産科婦人科学会
  • Place of Presentation: 大阪市(シンポジウム)
• [Presentation] 妊娠の成立・維持におけるNK細胞の機能 (2011)
  • Author(s): 福井淳史
  • Organizer: 日本胎盤学会
  • Place of Presentation: 東京都(招待講演)
• [Presentation] Changes in NK cells functions in normal pregnancy and preeclampsia (2011)
  • Author(s): Atsushi Fukui
  • Organizer: First Clinical Reproductive Immunology Symposium
  • Place of Presentation: Providence, RI, USA(招待講演)
• [Presentation] NK cell and its role in reproduction (2010)
  • Author(s): Atsushi Fukui
  • Organizer: International Conference on Reproductive Immunology
  • Place of Presentation: Shnagjai, China
  • Year and Date: 2010-11-30
• [Presentation] 妊娠高血圧症候群発症へのNK細胞Natural Cytotoxicity ReceptorとNK細胞産生サイトカインの関与 (2010)
  • Author(s): 福井淳史
  • Organizer: 日本妊娠高血圧学会
  • Place of Presentation: 東京都
• [Presentation] The expression of natural cytotoxicity receptors on natural killer cells from midsecretory endometrium and aborted decidua (2010)
  • Author(s): Atsushi Fukui
  • Organizer: 世界不妊学会議
  • Place of Presentation: Munich, Germany
• [Presentation] The expression of natural cytotoxicity receptors and the NK cell cytokines production in pregnant women with a history of recurrent pregnancy loss and pregnancy-induced hypertension (2010)
  • Author(s): Atsushi Fukui
  • Organizer: 世界不妊学会議
  • Place of Presentation: Munich, Germany
• [Presentation] The expression of natural cytotoxicity receptors and the NK cell cytokines production in pregnant women with a history of recurrent pregnancy loss or pregnancy induced hypertension (2010)
  • Author(s): Atsushi Fukui
  • Organizer: International Society for immunology of reproduction
  • Place of Presentation: Osaka, Japan
• [Presentation] 妊娠高血圧症候群発症にNK細胞Natural Cytotoxicity ReceptorsとNK細胞産生サイトカインが関与する (2010)
  • Author(s): 福井淳史
  • Organizer: 日本産科婦人科学会
  • Place of Presentation: 東京都
• [Presentation] Uterine and circulating natural killer cells and their roles in women with recurrent pregnancy losses, implantation failures or preeclampsia (2010)
  • Author(s): Atsushi Fukui
  • Organizer: 8^<th> European congress of reproductive immunology
  • Place of Presentation: Munich, Germany
• [Presentation] NK cell and its role in reproduction (2010)
  • Author(s): Atsushi Fukui
  • Organizer: 2^<nd> International conference of reproductive immunology
  • Place of Presentation: 中国、上海
• [Presentation] 妊娠高血圧症候群発症にNK細胞Natural Cytotoxicity ReceptorsとNK細胞産生サイトカインが関与する (2010)
  • Author(s): 福井淳史
  • Organizer: 第62回日本産科婦人科学会
  • Place of Presentation: 東京国際フォーラム(東京都)
• [Presentation] 妊娠高血圧症候群発症へのNK細胞Natural Cytotoxicity ReceptorとNK細胞産生サイトカインの関与 (2010)
  • Author(s): 福井淳史
  • Organizer: 第31回日本妊娠高血圧学会
  • Place of Presentation: 日本大学会館(東京都)
• [Presentation] The expression of natural cytotoxicity receptors and the NK cell cytokines production in pregnant women with a history of recurrent pregnancy loss or pregnancy induced hypertension (2010)
  • Author(s): Atsushi Fukui
  • Organizer: International symposium for immunology or reproduction
  • Place of Presentation: 大阪大学 銀杏会館(吹田市)
• [Presentation] The expression of natural cytotoxicity receptors on natural killer cells from midsecretory endometrium and aborted decidua (2010)
  • Author(s): Atsushi Fukui
  • Organizer: 20^<th> World Congress of Fertility and Sterility
  • Place of Presentation: Munich, Germany
• [Presentation] The expression of natural cytotoxicity receptors and the NK cell cytokines production in pregnant women with a history of recurrent pregnancy loss and pregnancy induced hypertension (2010)
  • Author(s): Atsushi Fukui
  • Organizer: 20^<th> World Congress of Fertility and Sterility
  • Place of Presentation: Munich, Germany
• [Presentation] 妊娠高血圧症候群発症におけるNK細胞Natural Cytotoxicity ReceptorsとNK細胞産生サイトカインの関与 (2009)
  • Author(s): 福井淳史
  • Organizer: 日本生殖免疫学会
  • Place of Presentation: 東京都
• [Presentation] 妊娠高血圧症候群におけるNK細胞 Natural Cytotoxicity Receptors とNK細胞産生サイトカインの関与 (2009)
  • Author(s): 福井淳史
  • Organizer: 日本生殖免疫学会
  • Place of Presentation: 東京都