Development of a therapeutic agent against ovarian clear cell carcinoma based on chemogenomics.
Project/Area Number |
21791551
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Obstetrics and gynecology
|
Research Institution | Kyoto University |
Principal Investigator |
MATSUMURA Noriomi Kyoto University, 医学研究科, 助教 (20452336)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
Keywords | 婦人科腫瘍学 / 卵巣癌 / 明細胞腺癌 / バイオインフォマティックス / 分子標的療法 / マイクロアレイ / 卵巣明細胞腺癌 / HNF1β |
Research Abstract |
Microarray analysis of ovarian clear cell carcinoma revealed similarity with renal cell carcinoma and activated Ras activity. Sorafenib, a multi-kinase inhibitor effective against renal cell carcinoma, showed prominent anti-tumor effect against ovarian clear cell carcinoma in an animal study. Sorafenib was administered to a chemoresistant recurrent ovarian clear cell carcinoma with the approval of Medical Ethics Committee in Kyoto University.
|
Report
(3 results)
Research Products
(84 results)
-
[Journal Article] The activated transforming growth factor-beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer.2011
Author(s)
Yamamura S, Matsumura N, Mandai M, Huang Z, Oura T, Baba T, Hamanishi J, Yamaguchi K, Kang HS, Okamoto T, Abiko K, Mori S, Murphy SK, Konishi I.
-
Journal Title
Int J Cancer.(Epub ahead of print)
Related Report
-
-
[Journal Article] Distinguishing primary from secondary mucinous ovarian tumors : an algorithm using the novel marker DPEP1.2011
Author(s)
Okamoto T, Matsumura N, Mandai M, Oura T, Yamanishi Y, Horiuchi A, Hamanishi J, Baba T, Koshiyama M, Shiozawa T, Konishi I.
-
Journal Title
Mod Pathol. 24(2)
Pages: 267-276
Related Report
-
-
-
[Journal Article] GPR54 is a target for suppression of metastasis in endometrial cancer.2011
Author(s)
Kang HS, Baba T, Mandai M, Matsumura N, Hamanishi J, Kharma B, Kondoh E, Yoshioka Y, Oishi S, Fujii N, Murphy SK, Konishi I.
-
Journal Title
Mol Cancer Ther. 10(4)
Pages: 580-590
Related Report
-
[Journal Article] Distinguishing primary from secondary mucinous ovarian tumors : an algorithm using the novel marker DPEP1.2011
Author(s)
Okamoto T, Matsumura N, Mandai M, Oura T, Yamanishi Y, Horiuchi A, Hamanishi J, Baba T, Koshiyama M, Shiozawa T, Konishi I.
-
Journal Title
Modern Pathology
Volume: 24
Pages: 267-276
Related Report
Peer Reviewed
-
[Journal Article] Oct4 expression in immature teratoma of the ovary : relevance to histologic grade and degree of differentiation.2011
Author(s)
Abiko K, Mandai M, Hamanishi J, Matsumura N, Baba T, Horiuchi A, Mikami Y, Yoshioka S, Wakasa T, Shiozawa T, Konishi I.
-
Journal Title
American Journal of Surgical Pathology
Volume: 34
Pages: 1842-1848
Related Report
Peer Reviewed
-
-
[Journal Article] GPR54 Is a Target for Suppression of Metastasis in Endometrial Cancer.2011
Author(s)
Kang HS, Baba T, Mandai M, Matsumura N, Hamanishi J, Kharma B, Kondoh E, Yoshioka Y, Oishi S, Fujii N, Murphy SK, Konishi I.
-
Journal Title
Molecular Cancer Therapeutics
Volume: 10
Pages: 580-590
Related Report
Peer Reviewed
-
[Journal Article] The activated transforming growth factor-beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer.2011
Author(s)
Yamamura S, Matsumura N, Mandai M, Huang Z, Oura T, Baba T, Hamanishi J, Yamaguchi K, Kang HS, Okamoto T, Abiko K, Mori S, Murphy SK, Konishi I.
-
Journal Title
International Journal of Cancer
Related Report
Peer Reviewed
-
[Journal Article] Oct4 expression in immature teratoma of the ovary : relevance to histologic grade and degree of differentiation.2010
Author(s)
Abiko K, Mandai M, Hamanishi J, Matsumura N, Baba T, Horiuchi A, Mikami Y, Yoshioka S, Wakasa T, Shiozawa T, Konishi I.
-
Journal Title
Am J Surg Pathol. 34(12)
Pages: 1842-1828
Related Report
-
[Journal Article] Sorafenib efficacy in ovarian clear cell carcinoma revealed by transcriptome profiling.2010
Author(s)
Matsumura N, Mandai M, Okamoto T, Yamaguchi K, Yamamura S, Oura T, Baba T, Hamanishi J, Kang HS, Matsui S, Mori S, Murphy SK, Konishi I.
-
Journal Title
Cancer Sci. 101(12)
Pages: 2658-2663
NAID
Related Report
-
-
-
-
[Journal Article] Targeting slow-proliferating ovarian cancer cells.2010
Author(s)
Kondoh E, Mori S, Yamaguchi K, Baba T, Matsumura N, Cory Barnett J, Whitaker RS, Konishi I, Fujii S, Berchuck A, Murphy SK.
-
Journal Title
Int J Cancer. 126(10)
Pages: 2448-2456
Related Report
-
-
[Journal Article] Sorafenib efficacy in ovarian clear cell carcinoma revealed by transcriptome profiling.2010
Author(s)
Matsumura N, Mandai M, Okamoto T, Yamaguchi K, Yamamura S, Oura T, Baba T, Hamanishi J, Kang HS, Matsui S, Mori S, Murphy SK, Konishi I.
-
Journal Title
Cancer Science
Volume: 101
Pages: 2658-2663
NAID
Related Report
Peer Reviewed
-
-
-
[Journal Article] Targeting slow-proliferating ovarian cancer cells.2010
Author(s)
Kondoh E, Mori S, Yamaguchi K, Baba T, Matsumura N, Cory Barnett J, Whitaker RS, Konishi I, Fujii S, Berchuck A, Murphy SK.
-
Journal Title
Int J Cancer. 126
Pages: 2448-2456
Related Report
Peer Reviewed
-
-
-
-
-
-
-
[Presentation] Oral presentation "Genomewide methylation analyses reveal a prominent role of HNF1 network genes, via hypomethylation, in ovarian clear cell carcinoma"2011
Author(s)
N.Matsumura, M.Mandai, T.Okamoto, K.Yamaguchi, T.Oura, T.Baba, S.Mori, S.Murphy, I.Konishi
Organizer
The 42 nd Annual Meeting of the Society of Gynecologic Oncologists
Place of Presentation
Florida
Year and Date
2011-03-06
Related Report
-
-
[Presentation] Genome-wide methylation analyses reveal a prominent role of HNF1 network genes, via hypomethylation, in ovarian clear cell carcinoma.2011
Author(s)
Yamaguchi K, Baba T, Matsumura N, Mandai M, Konishi I, Berchuck A, Murphy SK
Organizer
The 42nd Annual Meeting on Women's Cancer
Place of Presentation
Orland, FL, USA
Year and Date
2011-03-06
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-