| Project/Area Number |
21791551
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyoto University |
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Principal Investigator |
MATSUMURA Noriomi Kyoto University, 医学研究科, 助教 (20452336)
|
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 婦人科腫瘍学 / 卵巣癌 / 明細胞腺癌 / バイオインフォマティックス / 分子標的療法 / マイクロアレイ / 卵巣明細胞腺癌 / HNF1β |
|---|
| Research Abstract |
Microarray analysis of ovarian clear cell carcinoma revealed similarity with renal cell carcinoma and activated Ras activity. Sorafenib, a multi-kinase inhibitor effective against renal cell carcinoma, showed prominent anti-tumor effect against ovarian clear cell carcinoma in an animal study. Sorafenib was administered to a chemoresistant recurrent ovarian clear cell carcinoma with the approval of Medical Ethics Committee in Kyoto University.
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