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Elucidation of a gene-specific regulatory mechanism with progesterone in the human endometrial stromal cells

Research Project

Project/Area Number 21791559
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionYamaguchi University

Principal Investigator

TAKETANI Toshiaki  Yamaguchi University, 医学部附属病院, 助教 (70464328)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords生殖医学 / 子宮内膜 / 間質細胞 / プロゲステロン / エピジェネティクス / COX-2 / Mn-SOD
Research Abstract

ChIP assay revealed that TNFα increased NF-κB binding at both the COX-2 promoter and the Mn-SOD promoter, and that progesterone only inhibited the NF-κB binding at the COX-2 promoter. The histone acetylation level of the NF-κB response element of the Mn-SOD promoter was lower than that of the COX-2 promoter. The gene-specific action of progesterone may be due to the difference in chromatin structure at the NF-κB response elements in the COX-2 promoter and Mn-SOD promoter.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (8 results)

All 2009 Other

All Presentation (7 results) Remarks (1 results)

  • [Presentation] 子宮内膜間質細胞におけるCOX-2、Mn-SOD発現に及ぼすTNFαとプロゲステロンの影2009

    • Author(s)
      田村功、竹谷俊明, 他
    • Organizer
      第102回日本繁殖生物学会
    • Place of Presentation
      奈良/日本
    • Year and Date
      2009-09-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Differential modification of progesterone in TNF α-induced cyclooxygenase-2 and manganese superoxide dismutase expression in human endometrial stromal cells2009

    • Author(s)
      I.Tamura, T.Taketani, et al
    • Organizer
      25th European Society of Human Reproduction and Embryology
    • Place of Presentation
      Amsterdam/Holland
    • Year and Date
      2009-06-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 子宮内膜間質細胞(ESC)におけるTNFaのCOX-2、Mn-SOD発現に及ぼす作用とプロゲステロンの影響.2009

    • Author(s)
      田村功、竹谷俊明、他
    • Organizer
      第27回日本受精着床学会総会・学術講演会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Related Report
      2010 Final Research Report
  • [Presentation] Differential modification of progesterone in TNFa-induced COX-2 and Mn-SOD expression in human endometrial stromal cell.2009

    • Author(s)
      I.Tamura, T.Taketani, et al.
    • Organizer
      42th Annual Meeting of the Society for the Study on Reproduction
    • Place of Presentation
      amsterdam
    • Related Report
      2010 Final Research Report
  • [Presentation] Differential modification of progesterone in TNFa-induced cyclooxygenase-2 and manganese superoxide dismutase expression in human endometrial stromal cells.2009

    • Author(s)
      I.Tamura, T.Taketani, et al.
    • Organizer
      25th European Society of Human Reproduction and Embryology
    • Place of Presentation
      pittsburgh
    • Related Report
      2010 Final Research Report
  • [Presentation] 子宮内膜間質細胞(ESC)におけるTNFaのCOX-2、Mn-SOD発現に及ぼす作用とプロゲステロンの遺伝子特異的な影響2009

    • Author(s)
      田村功、竹谷俊明、他
    • Organizer
      第61回日本産科婦人科学会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Related Report
      2010 Final Research Report
  • [Presentation] 子宮内膜間質細胞(ESC)におけるTNFaのCOX-2、Mn-SOD発現に及ぼす作用とプロゲステロンの遺伝子特異的な影響2009

    • Author(s)
      田村功、竹谷俊明、他
    • Organizer
      第82回日本内分泌学会総会・学術講演会
    • Place of Presentation
      群馬県民会館(前橋市)
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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