Research Project
Grant-in-Aid for Young Scientists (B)
ChIP assay revealed that TNFα increased NF-κB binding at both the COX-2 promoter and the Mn-SOD promoter, and that progesterone only inhibited the NF-κB binding at the COX-2 promoter. The histone acetylation level of the NF-κB response element of the Mn-SOD promoter was lower than that of the COX-2 promoter. The gene-specific action of progesterone may be due to the difference in chromatin structure at the NF-κB response elements in the COX-2 promoter and Mn-SOD promoter.
All 2009 Other
All Presentation (7 results) Remarks (1 results)
