Elucidation of a gene-specific regulatory mechanism with progesterone in the human endometrial stromal cells
Project/Area Number |
21791559
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Obstetrics and gynecology
|
Research Institution | Yamaguchi University |
Principal Investigator |
TAKETANI Toshiaki Yamaguchi University, 医学部附属病院, 助教 (70464328)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
|
Keywords | 生殖医学 / 子宮内膜 / 間質細胞 / プロゲステロン / エピジェネティクス / COX-2 / Mn-SOD |
Research Abstract |
ChIP assay revealed that TNFα increased NF-κB binding at both the COX-2 promoter and the Mn-SOD promoter, and that progesterone only inhibited the NF-κB binding at the COX-2 promoter. The histone acetylation level of the NF-κB response element of the Mn-SOD promoter was lower than that of the COX-2 promoter. The gene-specific action of progesterone may be due to the difference in chromatin structure at the NF-κB response elements in the COX-2 promoter and Mn-SOD promoter.
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Report
(3 results)
Research Products
(8 results)