Functional analysis of Fbxw7 in uterine myometriuma and uterine sarcoma

• Project/Area Number: 21791560
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Kyushu University
• Principal Investigator: ONOYAMA Ichiro Kyushu University, 医学研究院・周産期小児医療学講座, 客員助教 (00444802)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 婦人科腫瘍学 / 子宮筋肉腫 / Fbxw7

Research Abstract

We investigated the expression of oncosuppressor Fbxw7 in gynecologic cancers. Among them, the expression of Fbxw7 is suppressed in ovarian cancers compared to ovarian tumors of borderline malignancy and benign tumors. We need more analysis about the relationship between Fbxw7 and cancer developments.

Research Products

• [Journal Article] SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. (2011)
  • Author(s): Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, Kung AL, Look T, Nakayama KI, DePinho RA, Wei W.
  • Journal Title: Nature. 471(7336) Pages: 104-109
  • Peer Reviewed
• [Journal Article] Fbxw7-dependent degradation of Notch is required for control of stemness and neuronal-glial differentiation in neural stem cells. (2011)
  • Author(s): Matsumoto A, Onoyama I, Sunabori T, Kageyama R, Okano H, Nakayama KI.
  • Journal Title: J Biol Chem. Feb 24.
  • Peer Reviewed
• [Journal Article] Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress. (2011)
  • Author(s): Matsumoto A, Tateishi Y, Onoyama I, Okita Y, Nakayama K, Nakayama KI.
  • Journal Title: Cancer Sci. 102(4) Pages: 749-755
  • NAID: 10029292153
  • Peer Reviewed
• [Journal Article] Ex vivo maintenance of hematopoietic stem cells by quiescence induction through Fbxw7α overexpression. (2011)
  • Author(s): Iriuchishima H, Takubo K, Matsuoka S, Onoyama I, Nakayama KI, Nojima Y, Suda T.
  • Journal Title: Blood. 117(8) Pages: 2373-2377
  • Peer Reviewed
• [Journal Article] Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver. (2011)
  • Author(s): Onoyama I, Suzuki A, Matsumoto A, Tomita K, Katagiri H, Oike Y, Nakayama K, Nakayama KI
  • Journal Title: J Clin Invest. 121(1) Pages: 342-354
  • Peer Reviewed
• [Journal Article] SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction (2011)
  • Author(s): Inuzuka H, et al
  • Journal Title: Nature Volume: 471(7336) Pages: 104-9
  • Peer Reviewed
• [Journal Article] Fbxw7-dependent degradation of Notch is required for control of stemness and neuronal-glial differentiation in neural stem cells (2011)
  • Author(s): Matsumoto A, et al
  • Journal Title: J.Biol.Chem. Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver (2011)
  • Author(s): Onoyama I, et al
  • Journal Title: J.Clin.Invest. Volume: 121(1) Pages: 342-54
  • Peer Reviewed
• [Journal Article] Complex regulation of cell-cycle inhibitors by Fbxw7 in mouse embryonic fibroblasts. (2010)
  • Author(s): Masuda K, Ishikawa Y, Onoyama I, Unno M, de Alboran IM, Nakayama KI, Nakayama K.
  • Journal Title: Oncogene. 29(12) Pages: 1798-1809
  • Peer Reviewed
• [Journal Article] Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer : Clinical significance. (2010)
  • Author(s): Iwatsuki M, Mimori K, Ishii H, Yokobori T, Takatsuno Y, Sato T, Toh H, Onoyama I, Nakayama KI, Baba H, Mori M.
  • Journal Title: Int J Cancer. 126(8) Pages: 1828-1837
  • Peer Reviewed
• [Journal Article] Complex regulation of cell-cycle inhibitors by Fbxw7 in mouse embryonic fibroblasts (2010)
  • Author(s): Masuda K., et al
  • Journal Title: Oncogene 29(12) Pages: 1798-809
  • Peer Reviewed
• [Journal Article] p53-Altered FBXW7 expression determines poor prognosis in gastric cancer cases. (2009)
  • Author(s): Yokobori T, Mimori K, Iwatsuki M, Ishii H, Onoyama I, Fukagawa T, Kuwano H, Nakayama KI, Mori M.
  • Journal Title: Cancer Res. 69(9) Pages: 3788-3794
  • Peer Reviewed
• [Journal Article] p53-Altered FBXW7 expression determines poor prognosis in gastric cancer cases (2009)
  • Author(s): Yokobori T., et al
  • Journal Title: Cancer Res. 69(9) Pages: 3788-94
  • Peer Reviewed
• [Presentation] ユビキチンリガーゼFbxw7の上皮性卵巣腫瘍における発現解析 (2010)
  • Author(s): 北出尚子、小野山一郎、小林裕明、和氣徳夫
  • Organizer: 第62回日本産科婦人科学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-23
• [Presentation] ユビキチンリガーゼFbxw7によるG0期維持機構とその破綻による発がん (2009)
  • Author(s): 小野山一郎
  • Organizer: 第14回生殖医学フォーラム
  • Place of Presentation: 大津
  • Year and Date: 2009-09-21
• [Presentation] ユビキチンリガーゼFbxw7による細胞周期制御と細胞分化制御 (2009)
  • Author(s): 小野山一郎、恒松良祐、小林裕明、中山敬一、和氣徳夫
  • Organizer: 第14回日本病態プロテアーゼ学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-08-21
• [Presentation] ユビキチンリガーゼFbxw7による細胞周期制御 (2009)
  • Author(s): 小野山一郎、恒松良祐、小林裕明、中山敬一、和氣徳夫
  • Organizer: 細胞分化制御と発がん抑制機構 第8回日本婦人科がん分子標的研究会
  • Place of Presentation: 福岡
  • Year and Date: 2009-07-03
• [Presentation] ユビキチンリガーゼFbxw7による細胞周期制御と細胞分化制 (2009)
  • Author(s): 小野山一郎、恒松良祐、小林裕明、和氣徳夫
  • Organizer: 第61回日本産科婦人科学会学術講演会
  • Place of Presentation: 京都
  • Year and Date: 2009-04-03
• [Book] 産科と婦人科 第78巻1号、特集婦人科がんのMolecular Biology、アポトーシス
  • Author(s): 小野山一郎、小林裕明
  • Publisher: 診断と治療社
• [Remarks] ホームページ等