New diagnostic criteria and useful diagnostic markers for patients with early hydatidiform mole

• Project/Area Number: 21791561
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Kyushu University
• Principal Investigator: KANEKI Eisuke Kyushu University, 九州大学病院, 助教 (90423508)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 胞状奇胎 / 絨毛性疾患 / 存続絨毛症 / 侵入奇胎 / 絨毛 / 絨毛癌

Research Abstract

296 samples of hydropic villi were classified according to DNA polymorphisms as androgenetic moles, dispermic triploids, or biparental diploids. We reviewed the outcomes of these patients. We evident that the patients with dispermic triploids are extremely low risk of postmolar GTD. The risk of postmolar GTD is also low in patients with androgenetic moles with small hydropic villi.

Research Products

• [Journal Article] 胞状奇胎の発生機構 (2011)
  • Author(s): 兼城英輔、和氣徳夫
  • Journal Title: 臨床産婦人科 Volume: 65(3) Pages: 237-241
• [Journal Article] Incidence of postmolar gestational trophoblastic disease in androgenetic moles and the morphological features associated with low risk, postmolar gestational trophoblastic disease (2010)
  • Author(s): Kaneki E, Kobayashi H, Wake N, et al
  • Journal Title: Cancer Science 101(7) Pages: 1717-1721
  • Peer Reviewed
• [Journal Article] 胞状奇胎の発生機構 (2010)
  • Author(s): 兼城英輔、和氣徳夫
  • Journal Title: 臨床産婦人科 65(3) Pages: 237-241
• [Journal Article] Incidence of postmolar gestational trophoblastic disease in androgenetic moles and the morphological features associated with low risk, postmolar gestational trophoblastic disease (2010)
  • Author(s): Kaneki E, Kobayashi H, Hirakawa T, Matsuda T, Kato H, Wake N
  • Journal Title: Cancer Science Volume: 101(7) Pages: 1717-21
  • Peer Reviewed
• [Journal Article] がん治療Update絨毛性疾患 (2009)
  • Author(s): 兼城英輔、和氣徳夫
  • Journal Title: 日本医師会雑誌 138巻 Pages: 264-267
• [Journal Article] がん治療Update絨毛性疾患 (2009)
  • Author(s): 兼城英輔、和氣徳夫
  • Journal Title: 日本医師会雑誌 138 Pages: 264-267
• [Presentation] 早期胞状奇胎症例の病理診断-DNA多型による遺伝子診断との比較検討- (2010)
  • Author(s): 兼城英輔
  • Organizer: 第28会日本絨毛性疾患研究会
  • Place of Presentation: 熊本市
  • Year and Date: 2010-09-30
• [Presentation] 胞状奇胎のDNA診断と、続発症のリスク (2010)
  • Author(s): 兼城英輔
  • Organizer: 第28会日本絨毛性疾患研究会
  • Place of Presentation: 熊本市
  • Year and Date: 2010-09-30
• [Presentation] 胞状奇胎のDNA 診断と (2009)
  • Author(s): 兼城英輔
  • Organizer: 続発症のリスク 第27会日本絨毛性疾患研究会日本絨毛性疾患研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-16
• [Presentation] 胞状奇胎のDNA診断と、続発症のリスク (2009)
  • Author(s): 兼城英輔
  • Organizer: 日本絨毛性疾患研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-16
• [Remarks] ホームページ等