Identification of endometrial cancer stem cells and endometrial stem cells for establishment of new molecular-targeting therapy

• Project/Area Number: 21791564
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Kyushu University
• Principal Investigator: TSUNEMATSU Ryosuke Kyushu University, 医学研究院, 助教 (20380529)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 子宮体癌幹細胞 / 子宮内膜幹細胞 / SP細胞 / Ras / ER経路 / 細胞老化 / Ras/ER経路

Research Abstract

FACS analysis of human endometrial cells recovered from menstrual blood revealed that they included about 2% of SP(side population) cells. Colony formation assay using SP cells and non-SP cells showed that SP cells formed colonies more efficiently than non-SP cell. These results indicated that SP cells recovered from human menstrual blood have self-renewing ability. Immunocytochemical staining of hEM SP cells for IL-1R and CXCR4 revealed that a few SP cells expressed both proteins.

Research Products

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