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Characteristic changes in endothelial function by administration of NO synthase inhibitor during placental formation

Research Project

Project/Area Number 21791569
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionNagoya City University

Principal Investigator

YAMAMOTO Tamao  Nagoya City University, 大学院・医学研究科, 研究員 (20405210)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords妊娠高血圧症候群 / 血管内皮機能障害 / 一酸化窒素 / 活性酸素
Research Abstract

It is found that administration of the NOS inhibitor L-NAME at early pregnancy developed hypertension in rat. Blood pressure was increasing, while birth body weight was smaller in L-NAME-treated rats than in saline-treated rats. Acetylcholine (ACh)-induced endothelial nitric oxide (NO) production in uterine artery was higher, although ACh-induced reactive oxygen species production was similar in L-NAME-treated rats. It is suggested that the increased endothelial NO production in uterine artery by administration of L-NAME may protect the development of hypertension in endothelium.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (16 results)

All 2010 2009

All Journal Article (9 results) (of which Peer Reviewed: 6 results) Presentation (6 results) Book (1 results)

  • [Journal Article] Glycogen storage disease type Ia (GSD Ia) during pregnancy : Report of a case complicated by fetal growth restriction and preeclampsia.2010

    • Author(s)
      Yamamoto T, Suzuki Y, Kaneko S, Hattori Y, Obayashi S, Suzumori N, Sugiura M.
    • Journal Title

      J Obstet Gynaecol Res. 36

      Pages: 1125-1129

    • NAID

      10031121757

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Biological investigation of prostacyclin in preeclamptic women seen reduced endothelial function.2010

    • Author(s)
      Yamamoto T, Suzuki Y, Kojima K, Suzumori N, Suzuki T.
    • Journal Title

      Hypertens Pregnancy. 29

      Pages: 484-491

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 妊娠高血圧症候群-発症予知・予防は可能か-2010

    • Author(s)
      鈴木佳克、山本珠生、伊藤猛雄
    • Journal Title

      産婦人科の実際 59

      Pages: 335-340

    • Related Report
      2010 Final Research Report
  • [Journal Article] The biological investigation of prostacyclin in preeclamptic women seen reduced endothelial function2010

    • Author(s)
      Yamamoto T, Suzuki Y, Kojima K, Suzumori N, Suzuki T
    • Journal Title

      Hypertens Pregnancy

      Volume: 29 Pages: 484-491

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glycogen storage disease type Ia (GSD Ia) during pregnancy : report of a case complicated by fetal growth restriction and preeclampsia.2010

    • Author(s)
      Yamamoto T, Suzuki Y, Kaneko S.Hattori Y.Obayashi S, Suzumori N, Sugiura M
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 36 Pages: 1125-1129

    • NAID

      10031121757

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 前置胎盤の病態と診断2010

    • Author(s)
      山本珠生、鈴木佳克
    • Journal Title

      ペリネイタルケア

      Volume: 29 Pages: 10-14

    • Related Report
      2010 Annual Research Report
  • [Journal Article] アンギオテンシンIIによる抵抗血管のトーヌス調節機構2009

    • Author(s)
      伊藤猛雄、渡邊義将、梶栗潤子、山本珠生、中野庸一郎、白石良久、上村裕一
    • Journal Title

      循環制御 30

      Pages: 121-126

    • Related Report
      2010 Final Research Report
  • [Journal Article] Characteristic changes in coronary artery at the early hyperglycaemic stage in a rat type 2 diabetes model and the effects of pravastatin.2009

    • Author(s)
      Kajikuri J, Watanabe Y, Ito Y, Ito R, Yamamoto T, Itoh T.
    • Journal Title

      Br J Pharmacol. 158

      Pages: 621-632

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characteristic changes in coronary actery at the early hyperglycaemicstage in a rat type 2 diabetes model and the effects of provastatin2009

    • Author(s)
      J Kajikuri, Y Watanabe, Y Ito, R Ito, T Yamamtot, T Itoh
    • Journal Title

      Br J Pharmacol 158

      Pages: 621-632

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] L-NAME投与による胎盤形成不全発症動物における血管内皮機能異常の研究2010

    • Author(s)
      山本珠生、鈴木佳克、多田豊曠、伊藤猛雄
    • Organizer
      第62回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-24
    • Related Report
      2010 Final Research Report
  • [Presentation] L-NAME投与による胎盤形成不全発症動物における血管内皮機能異常の研究2010

    • Author(s)
      山本珠生、鈴木佳克, ら
    • Organizer
      第62回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2010-04-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] L-NAME投与による胎盤形成不全発症動物における血管内皮機能異常の研究2010

    • Author(s)
      山本珠生、鈴木佳克、梶栗潤子、伊藤猛雄
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 課題研究報告:妊娠高血圧症候群の血管内皮機能障害に対する葉酸ならびにL-アルギニンの改善効果の基礎的・臨床的検討2009

    • Author(s)
      山本珠生、鈴木佳克、伊藤猛雄
    • Organizer
      第30回日本妊娠高血圧学会
    • Place of Presentation
      岡山
    • Year and Date
      2009-08-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 課題研究報告 「妊娠高血圧症候群の血管内皮機能障害に対する葉酸ならびにL-アルギニンの改善効果の基礎・臨床的検討」2009

    • Author(s)
      山本珠生
    • Organizer
      日本妊娠高血圧学会
    • Place of Presentation
      岡山コンベンションセンター(岡山)
    • Year and Date
      2009-08-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Does supplementation of L-arginine plus folic acid improve reduced endothelial function seen in preeclampsia2009

    • Author(s)
      Suzuki Y, Yamamoto T, Itoh T
    • Organizer
      Society for Gynecologic Investigation 3rd International Summit
    • Place of Presentation
      Sendai
    • Related Report
      2010 Final Research Report
  • [Book] 必携ハイリスク妊娠の診療を極める(妊娠高血圧症候群関連疾患)(江口勝人編)2009

    • Author(s)
      鈴木佳克、山本珠生
    • Publisher
      永井書店
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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