Study on the chromosome aberration and infertility of an egg.

• Project/Area Number: 21791570
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Osaka City University
• Principal Investigator: YOSHIDA Kayo Osaka City University, 大学院・医学研究科, 准教授 (30311921)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 遺伝子 / 細胞・組織 / 発現制御 / 発生・分化 / 放射線

Research Abstract

It is important to analyze the mechanisms of chromosome behavior in meiosis in mammals for chromosome aberrations in fetus. It will also contribute to diagnosis and treatment. We found that histone H2AX gene was involved in repair of DNA damages.We analyzed the effect of DNA damages by X-irradiation to early development of embryos. Furthermore, we made histone H2AX knock-out mouse and analyzed its effect after DNA damages.

Research Products

• [Journal Article] Damage-induced neuronal endopeptidase is critical for presynaptic formation of neuromuscular iunctions (2010)
  • Author(s): Nagata K., Kiryu-Seo S., Maeda M., Yoshida K., Morita T., Kiyama H.
  • Journal Title: J Neurosci. 30巻 Pages: 6954-6962
  • Peer Reviewed
• [Journal Article] Damage-induced neuronal endopeptidase is critical for presynaptic formation of neuromuscular iunctions. (2010)
  • Author(s): Nagata K., Kiryu-Seo S., Maeda M., Yoshida K., Morita T., Kiyama H.
  • Journal Title: J Neurosci. Volume: 30 Pages: 6954-6962
  • Peer Reviewed
• [Presentation] Study on the Effect of Space Radiation to Mammalian ES and iPS Cells to Their Development (2010)
  • Author(s): Yoshida, K., Yoshida S., Egichi-kasai K., Morita T.
  • Organizer: Journal Club(招待講演)
  • Place of Presentation: アメリカ合衆国NASAジョンソン宇宙センター
  • Year and Date: 2010-11-19
• [Presentation] Study on the Effect of Space Radiation to Mammalian ES and iPS Cells to Their Development (2010)
  • Author(s): Yoshida, K., Yoshida S., Egichi-kasai K., Morita T.
  • Organizer: Journal Club
  • Place of Presentation: アメリカ合衆国NASAジョンソン宇宙センター(招待講演)
  • Year and Date: 2010-11-19
• [Presentation] 万能細胞(ES,iPS細胞)を用いた宇宙環境の影響の解析 (2010)
  • Author(s): 吉田佳世、吉田周平、笠井清美、森田隆
  • Organizer: 日本宇宙生物科学会第24回大会
  • Place of Presentation: 東北大学・生命科学プロジェクト総合研究棟
  • Year and Date: 2010-09-17
• [Presentation] 万能細胞(ES, iPS細胞)を用いた宇宙環境の影響の解析 (2010)
  • Author(s): 吉田佳世、吉田周平、笠井清美、森田隆
  • Organizer: 日本宇宙生物科学会第24回大会
  • Place of Presentation: 東北大学・生命科学プロジェクト総合研究棟
  • Year and Date: 2010-09-17
• [Presentation] STUDY ON THE EFFECT OF SPACE RADIATION TO MANMMALIAN ES AND iPS CELLS TO THEIR DEVELOPMENT. (2010)
  • Author(s): Yoshida, K., Yoshida, S., Eguchi-kasai, K., Morita, T.
  • Organizer: 21st Annual NASA Space Radiation Investigator's Workshop
  • Place of Presentation: アメリカ合衆国ニューヨーク
  • Year and Date: 2010-05-17
• [Presentation] STUDY ON THE EFFECT OF SPACE RADIATION TO MANMMALIAN ES AND iPS CELLS TO THEIR DEVELOPMENT (2010)
  • Author(s): Yoshida, K., Yoshida, S., Eguchi-kasai, K., Morita, T.
  • Organizer: 21st Annual NASA Space Radiation Investigator's Workshop
  • Place of Presentation: アメリカ合衆国ニューヨーク
  • Year and Date: 2010-05-17
• [Presentation] マウス万能細胞を用いた宇宙環境が哺乳動物細胞の発生と生殖細胞に及ぼす影響の解析 (2010)
  • Author(s): 森田隆、吉田佳世、吉田周平、笠井清美
  • Organizer: 宇宙利用シンポジウム(第26回)
  • Place of Presentation: 宇宙航空研究開発機構・宇宙科学研究本部相模原キャンパス
  • Year and Date: 2010-01-25
• [Presentation] Deveropment of Heavy Ion-Irradiated Mouse ES Cells. (2009)
  • Author(s): Morita, T,. Yoshida, K., Yoshida, S., Eguchi-kasai, K.
  • Organizer: 日本宇宙生物科学会第23回大会
  • Place of Presentation: JAXA筑波宇宙センター
  • Year and Date: 2009-10-02
• [Presentation] Effect of Heavy Ion Radiation to Mouse ES Cells. (2009)
  • Author(s): Yoshida, K., Yoshida, S., Eguchi-kasai,K., Morita, T.
  • Organizer: Heavy Ions In Therapy And Space Symposium 2009
  • Place of Presentation: ドイツ連邦共和国ケルン
  • Year and Date: 2009-07-07
• [Remarks] ホームページ等
  • URL: http://www.med.osaka-cu.ac.jp/molecular-genetics/