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Innovation of prognosis and therapeutic method for complications in pregnancy using adipokine technology

Research Project

Project/Area Number 21791571
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionNara Medical University

Principal Investigator

NARUSE Katsuhiko  Nara Medical University, 医学部, 助教 (70453165)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords脂肪細胞 / アディポネクチン / アディポサイトカイン / 妊娠 / 妊娠糖尿病 / 妊娠高血圧症 / 絨毛細胞
Research Abstract

Cytokines derived from adipocyte (adipocytokine), mainly adiponectin, were studied to clarify the effects of adipocyte on trophoblasts in normal and complicated pregnancy. The effect of free fatty acid on secretion of adiponectin was suggested in pregnancy induced hypertension. Additionally, coordinal alteration of high molecular weight adiponectin and chemokine in the course of normal pregnancy were clarified.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (35 results)

All 2011 2010 2009

All Journal Article (15 results) (of which Peer Reviewed: 5 results) Presentation (20 results)

  • [Journal Article] Effect of tumour necrosis factor-a in combination with interferon-Y on first trimester extravilous trophoblast invasion.2011

    • Author(s)
      Otun HA, Lash GE, Innes BA, Bulmer JN, Naruse K, Hannon T, Searle RF, Robson SC.
    • Journal Title

      J Reprod Immunol 88

      Pages: 1-11

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effect of tumour necrosis factor-α in combination with interferon-γ on first trimester extravillous trophoblast invasion.2011

    • Author(s)
      Otun HA, Lash GE, Innes BA, Bulmer JN, Naruse K, Hannon T, Searle RF, Robson SC.
    • Journal Title

      J Reprod Immunol.

      Volume: 88 Pages: 1-11

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fatal Factors of Clinical Manifestations and Laboratory Testing in Patients with Amniotic Fluid Embolism.2010

    • Author(s)
      Oi H, Naruse K, Noguchi T, Sado T, Kimura S, Kanayama N, Terao T, Kobayashi H.
    • Journal Title

      Gynecol Obstet Invest. 70

      Pages: 138-144

    • Related Report
      2010 Final Research Report
  • [Journal Article] Secretion of cytokines by villous cytotrophoblast and extravillous trophoblast in the first trimester of human pregnancy.2010

    • Author(s)
      Naruse K, Innes BA, Bulmer JN, Robson SC, Searle RF, Lash GE.
    • Journal Title

      J Reprod Immunol 86

      Pages: 148-150

    • Related Report
      2010 Final Research Report
  • [Journal Article] 妊娠とアディポネクチン~正常妊婦の血中濃度推移と脂肪細胞における基礎的検討~2010

    • Author(s)
      成瀬勝彦
    • Journal Title

      糟尿病と妊振 10

      Pages: 32-35

    • Related Report
      2010 Final Research Report
  • [Journal Article] アディポネクチンを指標とした妊娠糖尿病および妊娠高血圧症候群の早期予知と介入効果~インスリン抵抗性周産期疾患の減少を目指して~2010

    • Author(s)
      成瀬勝彦, 小林浩, 佐道俊幸, 坂田麻理子, 吉田昭三, 大野木輝
    • Journal Title

      第41回「医学研究助成」研究報告集(三井生命厚生事業団) 41

      Pages: 7-9

    • Related Report
      2010 Final Research Report
  • [Journal Article] Secretion of Angiogenic Growth Factors by Vinous Cytotrophoblast and Extravillous Trophoblast in Early Human Pregnancy.2010

    • Author(s)
      Lash GE, Naruse K, Innes BA, Robson SC, Searle RF, Bulmer JN.
    • Journal Title

      Placenta 31

      Pages: 545-548

    • Related Report
      2010 Final Research Report
  • [Journal Article] Fatal Factors of Clinical Manifestations and Laboratory Testing in Patients with Amniotic Fluid Embolism.2010

    • Author(s)
      Oi H, Naruse K, Noguchi T, Sado T, Kimura S, Kanayama N, Terao T, Kobayashi H.
    • Journal Title

      Gynecol Obstet Invest.

      Volume: 70 Pages: 138-144

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Secretion of cytokines by villous cytotrophoblast and extravillous trophoblast in the first trimester of human pregnancy.2010

    • Author(s)
      Naruse K, Innes BA, Bulmer JN, Robson SC, Searle RF, Lash GE.
    • Journal Title

      J Reprod Immunol.

      Volume: 86 Pages: 148-150

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 妊娠とアディポネクチン~正常妊婦の血中濃度推移と脂肪細胞における基礎的検討~2010

    • Author(s)
      成瀬勝彦
    • Journal Title

      糖尿病と妊娠

      Volume: 10 Pages: 32-35

    • Related Report
      2010 Annual Research Report
  • [Journal Article] アディポネクチンを指標とした妊娠糖尿病および妊娠高血圧症候群の早期予知と介入効果~インスリン抵抗性周産期疾患の減少を目指して~2010

    • Author(s)
      成瀬勝彦, 小林浩, 佐道俊幸, 坂田麻理子, 吉田昭三, 大野木輝
    • Journal Title

      第41回「医学研究助成」研究報告集(三井生命厚生事業団)

      Volume: 41 Pages: 7-9

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Secretion of Angiogenic Growth Factors by Villous Cytotro phoblast and Extravillous Trophoblast in Early Human Pregnancy.2010

    • Author(s)
      Lash GE, Naruse K, Innes BA, Robson SC, Searle RF, Bulmer JN.
    • Journal Title

      Placenta Epub Ahead of Print

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The urokinase plasminogen activator (uPA) system in uterine natural killer cells in the placental bed during early pregnancy.2009

    • Author(s)
      Naruse K, Lash GE, Bulmer JN, Innes BA, Otun HA, Searle RF, Robson SC.
    • Journal Title

      Placenta 30

      Pages: 398-404

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] Oxytocin Hypersensitivity in Pregnant P-LAP Deficient Mice.2009

    • Author(s)
      Ishii M, Naruse K, Hattori A, Tsujimoto M, Ishiura S, Numaguchi Y, Murohara T, Kobayashi H, Mizutani S.
    • Journal Title

      Life Sci. 84

      Pages: 668-672

    • Related Report
      2010 Final Research Report
  • [Journal Article] Oxytocin Hypersensitivity in Pregnant P-LAP Deficient Mice.2009

    • Author(s)
      Ishii M, Naruse K, Hattori A, Tsujimoto M, Ishiura S, Numaguchi Y, Murohara T, Kobayashi H, Mizutani S.
    • Journal Title

      Life Science 84

      Pages: 668-672

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 正常妊娠における血中炎症性サイトカインとケモカインの経時的変化2011

    • Author(s)
      常見泰平、成瀬勝彦、大野木輝、佐道俊幸、野口武俊、小山恵美、大井豪一、小林浩
    • Organizer
      第21回腎と妊娠研究会
    • Place of Presentation
      埼玉
    • Year and Date
      2011-03-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 妊娠中の遊離脂肪酸(FFA)変動ならびにアディポサイトカインとの連関2010

    • Author(s)
      成瀬勝彦、大野木輝、常見泰平、野口武俊、佐道俊幸、北中孝司、大井豪一、小林浩.
    • Organizer
      第26回日本糖尿病・妊娠学会年次学術集会
    • Place of Presentation
      埼玉
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Correlation of free fatty acid and adiponectin in hypertensive pregnancy : key molecules for homeostatic inflammatory linkage.2010

    • Author(s)
      Naruse K, Onogi A, Sado T, Noguchi T, Komeda S, Koyama E, Nishioka K, Kitanaka T, Oi H, Kobayashi H.
    • Organizer
      17th World congress of the International Society for the Study of Hypertension (ISSHP).
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2010-10-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Correlation of free fatty acid and adiponectin in hypertensive pregnancy : key molecules for homeostatic inflammatory linkage.2010

    • Author(s)
      Naruse K, Onogi A, Sado T, Noguchi T, Komeda S, Koyama E, Nishioka K, Kitanaka T, Oi H, Kobayashi H.
    • Organizer
      17^<th> World congress of the International Society for the Study of Hypertension (ISSHP):一般演題より口演に選出
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2010-10-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 正常妊娠と妊娠高血圧症における遊離脂肪酸(FFA)とアディポネクチンの連関2010

    • Author(s)
      成瀬勝彦、大野木輝、小山恵美、米田聡美、西岡和弘、野口武俊、佐道俊幸、北中孝司、小林浩.
    • Organizer
      第34回日本産科婦人科栄養・代謝研究会
    • Place of Presentation
      三重
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Invasive activities of primary extravillous trophoblast via altered activity in low oxygen condition.2010

    • Author(s)
      Naruse K, Onogi A, Noguchi T, Sado T, Kitanaka T, Oi H, Kobayashi H.
    • Organizer
      XI International Congress of Reproductive Immunology (ICRI).
    • Place of Presentation
      Palm Cove Resort, Cairns, Australia
    • Year and Date
      2010-08-15
    • Related Report
      2010 Final Research Report
  • [Presentation] Invasive activities of primary extravillous trophoblast via altered activity in low oxygen condition2010

    • Author(s)
      Naruse K, Onogi A, Noguchi T, Sado T, Kitanaka T, Oi H, Kobayashi H.
    • Organizer
      XI International Congress of Reproductive Immunology (ICRI)
    • Place of Presentation
      Palm Cove Resort, Cairns, Australia
    • Year and Date
      2010-08-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 糖尿病・重症高血圧同時合併妊娠の臨床像に関する検討2010

    • Author(s)
      成瀬勝彦、佐道俊幸、小山恵美、米田聡美、大野木輝、吉澤順子、野口武俊、北中孝司、小林浩.
    • Organizer
      第20回腎と妊娠研究会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 妊娠時のケモカイン-アディポサイトカイン・クロストーク:正常妊娠および重症妊娠高血圧症における血中Monocyte Chemoattractant Protein(MCP)-1の推移から2009

    • Author(s)
      成瀬勝彦, 大野木輝, 佐道俊幸, 重富洋志, 伊東史学, 重光愛子, 北中孝司, 小林浩.
    • Organizer
      第24回日本生殖免疫学会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 正常妊娠経過中のアディポネクチンおよびインスリン抵抗性関連因子の経時的推移2009

    • Author(s)
      成瀬勝彦, 大野木輝, 吉田昭三, 佐道俊幸, 北中孝司, 大井豪一, 小林浩.
    • Organizer
      第25回日本糖尿病・妊娠学会年次学術集会
    • Place of Presentation
      四日市市
    • Year and Date
      2009-11-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] シンポジウム「妊娠とインスリン抵抗性」~妊娠とアディポネクチン:正常妊婦の血中濃度推移と脂肪細胞における基礎的検討2009

    • Author(s)
      成瀬勝彦、大野木輝、吉田昭三、佐道俊幸、北中孝司、大井豪一、小林浩.
    • Organizer
      第25回日本糖尿病・妊娠学会年次学術集会
    • Place of Presentation
      四日市市
    • Year and Date
      2009-11-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Adipocyte-derived cytokines alteration for systemic inflammation in hypertensive pregnancy : Studies into matemal serum and adipocyte cell line.2009

    • Author(s)
      Naruse K, Onogi A, Sado T, Shigetomi H, Komeda S, Koyama E, Kitanaka T, Oi H, Kobayashi H.
    • Organizer
      3rd SGI International Summit 2009.
    • Place of Presentation
      Sendai, Japan.
    • Year and Date
      2009-11-12
    • Related Report
      2010 Final Research Report
  • [Presentation] Adipocyte-derived cytokines alteration for systemic inflammation in hypertensive pregnancy : Studies into matemal serum and adipocyte cell line.2009

    • Author(s)
      Naruse K, Onogi A, Sado T, Shigetomi H, Komeda S, Koyama E, Kitanaka T, Oi H, Kobayashi H.
    • Organizer
      3rd SGI International Summit 2009
    • Place of Presentation
      Sendai, Japan.
    • Year and Date
      2009-11-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト初期胎盤由来の絨毛細胞低酸素培養上清におけるサイトカイン産生2009

    • Author(s)
      成瀬勝彦, 大野木輝, 佐道俊幸, 吉澤順子, 重富洋志, 北中孝司, 大井豪一, 小林浩.
    • Organizer
      第17回日本胎盤学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effects of Adiponectin in Differentiation, Invasion and Migration of Human Trophoblastic Cells.2009

    • Author(s)
      Onogi A, Naruse K, Shigetomi H, Yoshizawa Y, Noguchi H, Sado T, Kitanaka T, Oi H, Kobayashi H.
    • Organizer
      15th World Congress of International Federation of Placenta Association (IFPA).
    • Place of Presentation
      Adelaide, Austraria
    • Year and Date
      2009-10-06
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Angiopoietin-like Protein 2 (AngPTL2) in Human Maternal Serum, Amniotic Fluid and Term Placental Trophoblast in Pregnancy.2009

    • Author(s)
      Naruse K, Endo M, Onogi A, Shigetomi H, Yoshizawa Y, Sado T, Oi H, Oike Y, Kobayashi H.
    • Organizer
      15th World Congress of International Federation of Placenta Association (IFPA).
    • Place of Presentation
      Adelaide, Austraria
    • Year and Date
      2009-10-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Adipocyte-derived cytokines in hypertensive pregnancy : A trigger for systemic inflammation.2009

    • Author(s)
      Naruse K, Onogi A, Sado T, Shigetomi H, Yoshida S, Kitanaka T, Oi H, Kobayashi H.
    • Organizer
      European branch of International Society for Study of Hypertension in Pregnancy (ESSHP).
    • Place of Presentation
      Oxford, England.
    • Year and Date
      2009-09-10
    • Related Report
      2010 Final Research Report
  • [Presentation] Adipocyte-derived cytokines in hypertensive pregnancy : A trigger for systemic inflammation2009

    • Author(s)
      Naruse K, Onogi A, Sado T, Shigetomi H, Yoshida S, Kitanaka T, Oi H, Kobayashi H.
    • Organizer
      European branch of International Society for Study of Hypertension in Pregnancy (ESSHP).
    • Place of Presentation
      Oxford, England.
    • Year and Date
      2009-09-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 妊娠糖尿病妊婦における多量体アディポネクチンの動態と治療マーカーとしての可能性2009

    • Author(s)
      成瀬勝彦, 植栗千陽, 重富洋志, 坂田麻理子, 佐道俊幸, 北中孝司, 大井豪一, 小林浩.
    • Organizer
      第45回日本周産期・新生児医学会学術集会
    • Place of Presentation
      名古屋市
    • Year and Date
      2009-07-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脂肪細胞および絨毛細胞培養系におけるアディポネクチンの誘導と浸潤・分化の制御.2009

    • Author(s)
      成瀬勝彦、大野木輝、野口武俊、坂田麻理子、佐道俊幸、北中孝司、大井豪一、小林浩.
    • Organizer
      第61回日本産科婦人科学会学術講演会
    • Place of Presentation
      京都市
    • Year and Date
      2009-04-05
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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