Basic research for regulating the APS by utilizing the adjuvant properties of natural killer T cells

• Project/Area Number: 21791572
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Saitama Medical University
• Principal Investigator: SUZUKI Motoharu Saitama Medical University, 医学部, 助教 (50406443)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 産婦人科 / 免疫 / 自己免疫 / 癌 / NKT細胞 / 樹状細胞 / 自己免疫疾患

Research Abstract

The activation of NKT cells enhances production of IL-12p70 while inhibiting the IL-23 production by dendritic cells, and in turn down-regulating the IL-17 production by memory CD4+ T cells. The results suggest that NKT cells modify the IL-12p70/IL-23 balance to enhance the IL-12p70-induced cell-mediated immunity and suppress the IL-23-dependent inflammatory pathologies.

Research Products

• [Journal Article] Human chorionic gonadotropin confers resistance to oxidative stress-induced apoptosis in decidualizing human endometrial stromal cells. (2011)
  • Author(s): Kajihara, T., Uchino, S., Suzuki, M., Itakura, A., Brosens, J.J., Ishihara, O.
  • Journal Title: Fertil.Steril. 95 Pages: 1302-1307
• [Journal Article] Human chorionic gonadotropin confers resistance to oxidative stress-induced apoptosis in decidualizing human endometrial stromal cells. (2011)
  • Author(s): Kajihara, T., et.al.
  • Journal Title: Fertil.Steril. Volume: 95 Pages: 1302-1307
  • Peer Reviewed
• [Journal Article] Bisphenol A in combination with TNFα selectively induces Th2 cell-promoting dendritic cells in vitro with an estrogen-like activity. (2010)
  • Author(s): Guo, H., Liu, T-Y., Uemura, Y., Jiao.S., Wang, D., Lin, Z., Narita, Y., Suzuki, M., Hirosawa, N., Ichihara, Y., Ishihara, O., Kikuchi H., Sakamoto, Y., Senju, S., Zhang, Q., Ling, F.
  • Journal Title: Cell.Mol.Immunol. 7 Pages: 227-234
• [Journal Article] NKT細胞のアジュバント効果と抗腫瘍免疫応答への応用 (2010)
  • Author(s): 成田弥生, 鈴木元晴, 劉天懿, 村上真理, 松岡由和, 中塚隆介, 長谷真, 河野比良夫, 佐々木豊, 廣澤成美, 坂本安, 植村靖史, 薗田精昭
  • Journal Title: Cytometry Research 20(1) Pages: 19-25
• [Journal Article] Bisphenol A in combination with TNFα selectively induces Th2 cell-promoting dendritic cells in vitro with an estrogen-like activity. (2010)
  • Author(s): Guo, H., et.al.
  • Journal Title: Cell.Mol.Immunol. Volume: 7 Pages: 227-234
  • Peer Reviewed
• [Journal Article] NKT細胞のアジュバント効果と抗腫瘍免疫応答への応用 (2010)
  • Author(s): 成田弥生, 他
  • Journal Title: Cytometry Research Volume: 20 Pages: 19-25
  • Peer Reviewed
• [Journal Article] NKT細胞のアジュバント効果と抗腫瘍免疫応答への応用 (2010)
  • Author(s): 成田弥生
  • Journal Title: Cytometry Research (印刷中)
  • Peer Reviewed
• [Journal Article] Bisphenol A in combination with TNFα selectively induces Th2 cell-promoting dendritic cells in vitro with an estrogen-like activity. (2010)
  • Author(s): Hongchuan Guo
  • Journal Title: Cellular & Molecular Immunology (印刷中)
  • Peer Reviewed
• [Journal Article] Cytokine-dependent modification of IL-12p70 and IL-23 balance in dendritic cells by ligand activation of Vα24 invariant natural killer T cells. (2009)
  • Author(s): Suzuki, M., Uemura, Y., Liu, T-Y., Narita, Y., Nakatsuka, R., Araki, T., Matsumoto, M., Iwai L.K., Hirosawa, N., Matsuoka, Y., Murakami, M., Kimura, T., Hase, M., Kohno, H., Sasaki, Y., Ichikawa, Y., Ishihara, O., Kikuchi, H., Sakamoto, Y., Jiao, S-C., Senju, S., Sonoda, Y.
  • Journal Title: J.Immunol.(*equal contribution) 183 Pages: 201-208
• [Journal Article] Increased ovarian follicle atresia in obese Zucker rats is associated with enhanced expression of the forkhead transcription factor FOXO1. (2009)
  • Author(s): Kajihara,T., Uchino, S., Suzuki, M., Itakura, A., Brosens, J.J., Ishihara, O.
  • Journal Title: Med.Mol.Morphol. 42 Pages: 216-221
  • NAID: 10027269548
• [Journal Article] Cytokine-dependent modification of IL-12p70 and IL-23 balance in dendritic cells by ligand activation of Vα24 invariant natural killer T cells. (2009)
  • Author(s): 鈴木元晴
  • Journal Title: Journal of Immunology 183 Pages: 201-208
  • Peer Reviewed
• [Presentation] 過去5年間のTVM手術の成績と今後の展望 (2010)
  • Author(s): 木村真智子
  • Organizer: 第14回産婦人科臨床フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2010-12-10
• [Presentation] 分娩誘発の成否を分けるキー・ファクター229例の検討 (2010)
  • Author(s): 大塚純一
  • Organizer: 第120回日本産科婦人科学会関東連合地方部会
  • Place of Presentation: つくば
  • Year and Date: 2010-11-28
• [Presentation] 羊水塞栓症による妊産婦死亡とその対応 (2010)
  • Author(s): 中山真人
  • Organizer: 第78回日本産科婦人科学会埼玉地方部会・埼玉県産婦人科医会平成22年度後期学術集会
  • Place of Presentation: さいたま
  • Year and Date: 2010-11-13
• [Presentation] 妊娠中に高トリグリセリド血症を認め、帝王切開後に急性膵炎を来した一例 (2010)
  • Author(s): 鈴木元晴
  • Organizer: 埼玉県産婦人科医学会後期学術集会
  • Place of Presentation: さいたま
  • Year and Date: 2010-11-13
• [Presentation] 血中好中球/リンパ球比は子宮内膜症の診断マーカーとなりうるか? (2010)
  • Author(s): 新澤麗
  • Organizer: 第52回埼玉県産婦人科医会ホルモンと生殖医学研究会
  • Place of Presentation: さいたま
  • Year and Date: 2010-07-24
• [Presentation] 腹腔鏡手術後に発症したポートサイトヘルニアの一例 (2010)
  • Author(s): 鈴木元晴
  • Organizer: 埼玉県産婦人科医学会前期学術集会
  • Place of Presentation: さいたま
  • Year and Date: 2010-06-19
• [Presentation] IUFDに至ったSLE合併妊娠の2例 (2010)
  • Author(s): 玉石絢香
  • Organizer: 第47回埼玉県医学総会
  • Place of Presentation: さいたま
  • Year and Date: 2010-01-24
• [Presentation] Cytokine-dependent modification of IL-12p70 and IL-23 balance in dendritic cells by ligand activation of Vα24 invariant natural killer T cells (2010)
  • Author(s): Y.Uemura
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: Kobe, Japan.
• [Presentation] Distinct subsets of human invariant NKT cells differentially regulate T helper responses via dendritic cells (2010)
  • Author(s): T.Liu
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: Kobe, Japan.
• [Presentation] Role of human non-invariant NKT lymphocytes in the maintenance of type 2 T helper environment during pregnancy (2010)
  • Author(s): M.Suzuki
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: Kobe, Japan.
• [Presentation] Bisphenol A in combination with TNFα selectively induces Th2 cell-promoting dendritic cells in vitro with an estrogen-like activity (2010)
  • Author(s): Y.N.Nobori
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: Kobe, Japan.
• [Presentation] 子宮内膜脱落膜化細胞の酸化ストレス抵抗性獲得メカニズムの検討 (2010)
  • Author(s): 梶原健
  • Organizer: 第62回日本産科婦人科学会総会・学術集会
  • Place of Presentation: 東京
• [Presentation] Role of human non-invariant NKT lymphocytes in the maintenance of type 2 T helper environment during pregnancy (2010)
  • Author(s): Suzuki, M., et.al.
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸国際コンベンションセンター(兵庫県)
• [Presentation] Modification of IL-12p70 and IL-23 balance in dendritic cells by ligand activation of Valpha24 invariant NKT cells (2009)
  • Author(s): Motoharu Suzuki
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] Modification of IL-12p70 and IL-23 balance in dendritic cells by Valpha24 invariant NKT cells (2009)
  • Author(s): Yasushi Uemura
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都
• [Presentation] Cytokine-dependent modification of IL-12p70 and IL-23 balance in dendritic cells by ligand activation of Vα24 invariant NKT cells (2009)
  • Author(s): Tianyi Liu
  • Organizer: 第39回日本免疫学会総会・学術総会
  • Place of Presentation: 大阪