Analysis of a new molecule target action of topotecan using a promoter microarray

• Project/Area Number: 21791578
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Osaka Medical College
• Principal Investigator: SASAKI Hiroshi Osaka Medical College, 医学部, 助教 (80432491)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: シスプラチン / トポテカン / プラチナ耐性 / Akt / NF・B / VEGF / 卵巣癌 / NFκB / NFкB

Research Abstract

We revealed the mechanism that Topotecan reacquire the effect of cisplatin in platinum resistance ovarian cancer. Furthermore we revealed the mechanism of angiogenesis by cisplatin in platinum resistance ovarian cancer.

Research Products

• [Journal Article] Prognostic effect of epidermal growth factor receptor gene mutations and the aberrant phosphorylation of Akt and ERK in ovarian cancer. (2011)
  • Author(s): Tanaka Y, Sasaki H, Ohmichi M.
  • Journal Title: Cancer Biol Ther. 11(1) Pages: 50-57
  • Peer Reviewed
• [Journal Article] Topotecan as a molecular targeting agent which blocks the Akt and VEGF cascade in platinum-resistant ovarian cancers. (2010)
  • Author(s): Tsunetoh S, Sasaki H, Ohmichi M.
  • Journal Title: Cancer Biol Ther. 10(11) Pages: 1137-1146
  • Peer Reviewed
• [Journal Article] Topotecan as a molecular targeting agent which blocks the Akt and VEGF cascade in platinum-resistant ovarian cances. (2010)
  • Author(s): 佐々木浩, 恒遠啓示
  • Journal Title: Cancer Biology and Therapy. Volume: 11 Pages: 1137-1137
  • Peer Reviewed
• [Journal Article] Long-term follow-up of neoadjuvant intraarterial chemotherapu using an original four-lumen double balloon(4L-DB)catheter for locally advanced uterine cervical cancer (2009)
  • Author(s): 寺井義人
  • Journal Title: Int J Clin Oncol 14 Pages: 56-62
  • Peer Reviewed
• [Journal Article] 当科における再発上皮性卵巣癌の治療成績 (2009)
  • Author(s): 田中良道
  • Journal Title: 産婦人科の進歩 61 Pages: 17-20
• [Journal Article] 子宮頸部微小浸潤扁平上皮癌の子宮温存の適応と限界 (2009)
  • Author(s): 寺井義人
  • Journal Title: 臨床婦人科産科 63 Pages: 1486-1489
  • Peer Reviewed
• [Presentation] 卵巣癌におけるGPR30の免疫組織化学的検討 (2010)
  • Author(s): 佐々木浩
  • Organizer: 癌治療学会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2010-10-28
• [Presentation] 子宮内膜癌に対するmedroxyprogesterone acetate(MPA)の作用機序 (2010)
  • Author(s): 佐々木浩
  • Organizer: 第61回日本産科婦人科学会総会・学術講演会
• [Presentation] 卵巣癌における抗癌剤感受性に基づいた新規 molecular marker としてのNFκB の意義 (2010)
  • Author(s): 佐々木浩
  • Organizer: 第62回日本産科婦人科学会総会・学術講演会
• [Presentation] 子宮内膜癌に対する medroxyprogesterone acetate(MPA)の作用機序 (2009)
  • Author(s): 佐々木浩
  • Organizer: 第61回 日本産科婦人科学会学術講演会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-04-03
• [Presentation] Topoisomerase linhibitor であるtopotecan のCDDP 耐性解除機構 (2009)
  • Author(s): 佐々木浩
  • Organizer: 第60回日本産科婦人科学会総会・学術講演会
• [Presentation] topoisomerase I inhibitor であるtopotecan はin vivo においてCDDP耐性を解除するか? (2008)
  • Author(s): 恒遠啓示、佐々木浩
  • Organizer: 第60回日本産科婦人科学会総会・学術講演会
• [Presentation] 卵巣癌におけるEGFR 遺伝子変異とその下流シグナル分子の発現解析
  • Author(s): 田中良道、佐々木浩、大道正英