| Project/Area Number |
21791582
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
HARADA Kazuhiko 独立行政法人国立循環器病研究センター, 薬剤部, 常勤薬剤師 (30509112)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 間葉系幹細胞 / 細胞移植 / 新生児低酸素性虚血性脳症 / 性差 / 脳損傷 / 卵膜 / 進行性脳損傷 / 細胞増殖因子 |
|---|
| Research Abstract |
Rat fetal membrane-derived mesenchymal stem cells (MSC) were transplanted into rat model of hypoxic-ischemic encephalopathy (HIE) intracerebrally. There were no statistically significant differences between MSC treatment and control groups in quantitative histological analysis. On the other hands, there were statistically significant differences on the degree of slowly progressive brain damage (SPBD) following hypoxic-ischemic insults after sexual maturation between male and female rats. Of the HI insult groups, the results of water maze task and the ipsilateral hemispheric areas did not differ by sex in the no-training groups, while they differed significantly by sex in the pre-training groups. In contrast to the task-specific differences in female groups, there were no differences based on training in the male groups. Taken together, it was considered that the progression of SPBD was related to at least in part through sex hormones. And also, it was considered that the responsibilities against exogenous factors might be different by sex.
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