Effect of inhibition targeting TS gene for chemotherapy sensitivity in head and neck adenoid cystic carcinoma

• Project/Area Number: 21791586
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Hirosaki University
• Principal Investigator: SHIRASAKI Takashi Hirosaki University, 大学院・医学研究科, 客員研究員 (20419980)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: TS遺伝子 / 頭頸部癌 / 抗癌剤 / 腺様嚢胞癌 / TS遺伝 / siRNA / 5-FU

Research Abstract

Adenoid cystic carcinoma(ACC) is resistant to 5-FU treatment. We investigated whether reductive expression of the TS gene improves chemo-sensitivity for 5-FU,it as well as the in vivo effect of TS inhibition. Results showed that TS gene inhibition did not improve chemo-sensitivity while it was effective in in vivo experiments.

Research Products

• [Journal Article] Effects of small interfering RNA targeting thymidylate synthase on survival of ACC3 cells from salivary adenoid cystic carcinoma (2008)
  • Author(s): Takashi Shirasaki, Shin-ichiro Maruya, Hiroki Mizukami, Seiji Kakehata, Hidekachi Kurotaki, Soroku Yagihashi, Hideichi Shinkawa
  • Journal Title: BMC Cancer 8 Pages: 348-348
  • Peer Reviewed
• [Presentation] siRNAを用いたTS knock down の唾液腺腺様嚢胞癌への影響 (2010)
  • Author(s): 白崎隆
  • Organizer: 第151回日耳鼻青森県地方部会
  • Place of Presentation: 青森県
  • Year and Date: 2010-03-14
• [Presentation] siRNAを用いたTS knock downの唾液腺腺様嚢胞癌細胞への影響 (2009)
  • Author(s): 白崎隆
  • Organizer: 第110回日本耳鼻咽喉科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-15
• [Presentation] siRNAを用いたTS knock down の唾液腺腺様嚢胞癌への影響 (2009)
  • Author(s): 白崎隆
  • Organizer: 第110回日本耳鼻咽喉科学会
  • Place of Presentation: 東京都
  • Year and Date: 2009-05-15
• [Remarks] ホームページ等