Effect of inhibition targeting TS gene for chemotherapy sensitivity in head and neck adenoid cystic carcinoma
| Project/Area Number |
21791586
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Hirosaki University |
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Principal Investigator |
SHIRASAKI Takashi Hirosaki University, 大学院・医学研究科, 客員研究員 (20419980)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | TS遺伝子 / 頭頸部癌 / 抗癌剤 / 腺様嚢胞癌 / TS遺伝 / siRNA / 5-FU |
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| Research Abstract |
Adenoid cystic carcinoma(ACC) is resistant to 5-FU treatment. We investigated whether reductive expression of the TS gene improves chemo-sensitivity for 5-FU,it as well as the in vivo effect of TS inhibition. Results showed that TS gene inhibition did not improve chemo-sensitivity while it was effective in in vivo experiments.
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Report
(3 results)
Research Products
(5 results)
