Identification of responsible miRNAs associated with an acquired resistance for cis-diamminedichloroplatinum by microarray analyses in human head and neck squamous cell carcinoma

• Project/Area Number: 21791588
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Tohoku University
• Principal Investigator: OGAWA Takenori Tohoku University, 病院, 助教 (50375060)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 癌 / マイクロアレイ / 薬剤反応性 / 薬剤応答性

Research Abstract

The identification of the resistance-related microRNA clusters was conducted between RPMI2650CR and RPMI2650 using microRNA microarray. Furthermore, clinical study showed that miR34a could be a strong prognostic biomarker of CDDP treated sinonasal squamous cell carcinomas.

Research Products

• [Journal Article] Surgical treatment is recommended for advanced oral squamous cell carcinoma. (2011)
  • Author(s): Ogawa T, Matsuura K, Shiga K, Tateda M, Katagiri K, Kato K, Saijo S, Kobayashi T.
  • Journal Title: Tohoku J Exp Med. 223-1巻 Pages: 17-25
  • NAID: 10027806505
  • Peer Reviewed
• [Journal Article] Surgical treatment is recommended for advanced oral squamous cell carcinoma. (2011)
  • Author(s): Ogawa T, Matsuura K, Shiga K, Tateda M, Katagiri K, Kato K, Saijo S, Kobayashi T.
  • Journal Title: Tohoku J Exp Med. Volume: 223 Pages: 17-25
  • NAID: 10027806505
  • Peer Reviewed
• [Journal Article] A cDNA microarray analysis identifies 52 genes associated with CDDP susceptibility in head and neck squamous cell carcinoma cell lines. (2010)
  • Author(s): Ogawa T, Furukawa T, Shiga K, Hashimoto S, Ogawa K, Kobayashi T, Horii A.
  • Journal Title: EAORL. 267-1巻 Pages: 123-129
  • Peer Reviewed
• [Journal Article] Survival of a free jejunal graft after the resection of its nutrient vessels. (2010)
  • Author(s): Ogawa T, Matsuura K, Kato K, Sariishi T, Goto T, Matsumoto K, Saijo S.
  • Journal Title: ANL. 37-1巻 Pages: 125-128
  • Peer Reviewed
• [Journal Article] Upregulation of IGF2 (insulin-like growth factor 2) is associated with an acquired resistance for cis-diamminedichloroplatinum in human head and neck squamous cell carcinoma. (2010)
  • Author(s): Ogawa T, Ogawa K, Shiga K, Furukawa T, Nagase H, Hashimoto S, Kobayashi T, Horii A.
  • Journal Title: EAORL. 267-10巻 Pages: 1599-1606
  • Peer Reviewed
• [Journal Article] 中咽頭癌133例の臨床統計 (2010)
  • Author(s): 小川武則, 志賀清人, 鈴木貴博, 加藤健吾, 小林俊光
  • Journal Title: 耳鼻咽喉科展望 53巻 Pages: 16-17
  • NAID: 130004546328
• [Journal Article] 早期中咽頭癌(T1、T2)の治療 中咽頭癌に対する化学放射線治療 (2010)
  • Author(s): 小川武則, 志賀清人, 浅田行紀, 加藤健吾, 松浦一登, 西條茂, 小林俊光
  • Journal Title: 耳鼻と臨床 56巻 Pages: 12-20
• [Journal Article] 耳前部より総頸動脈分岐間を通り、下咽頭に穿通した杙創の1例 (2010)
  • Author(s): 佐藤宏樹, 小川武則, 志賀清人, 大島猛史, 小林俊光
  • Journal Title: 頭頸部外科 20-2巻 Pages: 135-139
  • NAID: 10029078837
  • Peer Reviewed
• [Journal Article] ダブル・スコープ法による内視鏡的咽喉頭手術(ELPS)について頭頸部癌 (2010)
  • Author(s): 松浦一登, 野口哲也, 片桐克則, 今井隆之, 石田英一, 角田梨紗子, 浅田行紀, 小川武則, 加藤健吾, 西條茂
  • Journal Title: 36-4巻 Pages: 466-472
  • Peer Reviewed
• [Journal Article] Upregulation of IGF2 (insulin-like growth factor 2) is associated with an acquired resistance for cis-diamminedichloroplatinum in human head and neck squamous cell carcinoma. (2010)
  • Author(s): Ogawa T, Ogawa K, Shiga K, Furukawa T, Nagase H, Hashimoto S, Kobayashi T, Horii A.
  • Journal Title: Eur Arch Otorhinolaryngol. Volume: 267 Pages: 1599-1606
  • Peer Reviewed
• [Journal Article] A cDNA microarray analysis identifies 52 genes associated with cis-dia mminedichloroplatinum susceptibility in head and neck squamous cell carcinoma cell lines (2010)
  • Author(s): Ogawa T, Furukawa T, Shiga K, Hashimoto S, Ogawa K, Kobayashi T, Horii A.
  • Journal Title: Eur Arch Otorhinolaryngol 267 Pages: 123-129
  • Peer Reviewed
• [Journal Article] Survival of a free jejunal graft after the resection of its nutrient vessels (2010)
  • Author(s): Ogawa T, Matsuura K, Kato K, Sariishi T, Goto T, Matsumoto K, Saijo S.
  • Journal Title: Auris Nasus Larynx 37(1) Pages: 125-128
  • Peer Reviewed
• [Presentation] Identification of responsible genes associated with an acquired resistance for cis-diamminedichloroplatinum by microarray analyses of mRNA and miRNA in human head and neck squamous cell carcinoma. (2010)
  • Author(s): Takenori Ogawa, Kiyoto Shiga, Sho Hashimoto, Toshimitsu Kobayashi, Akira Horii
  • Organizer: IFHNOS2010.
  • Place of Presentation: Seoul
  • Year and Date: 2010-06-16
• [Presentation] Identification of responsible genes associated with an acquired resistance for cis-diamminedichloroplatinum by microarray analyses of mRNA and miRNA in human head and neck squamous cell carcinoma (2010)
  • Author(s): Takenori Ogawa, Kiyoto Shiga, Sho Hashimoto, Toshimitsu Kobayashi, Akira Horii
  • Organizer: IFHNOS2010
  • Place of Presentation: 韓国(ソウル)
  • Year and Date: 2010-06-16
• [Presentation] 中咽頭癌に対する化学放射線治療 (2010)
  • Author(s): 小川武則
  • Organizer: 第15回頭頸部癌化学療法研究会
  • Place of Presentation: 福岡
  • Year and Date: 2010-03-06
• [Presentation] 中咽頭癌133例の臨床統計 (2009)
  • Author(s): 小川武則
  • Organizer: 第15回北日本癌治療研究会
  • Place of Presentation: 仙台
  • Year and Date: 2009-10-24
• [Presentation] 小川武則放射線性頸動脈狭窄を有する下咽頭癌の遊離空腸再建例 (2009)
  • Author(s): 野口直哉
  • Organizer: 第138回宮城県地方部会
  • Place of Presentation: 仙台
  • Year and Date: 2009-09-05
• [Presentation] 志賀清人他頭蓋底浸潤した鼻副鼻腔癌に対するTPF同時併用化学放射線治療の治療効果 (2009)
  • Author(s): 小川武則
  • Organizer: 第21回頭蓋底外科学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-07-03
• [Presentation] 下咽頭・喉頭局所進行癌に対する化学放射線治療成績の検討 (2009)
  • Author(s): 小川武則
  • Organizer: 第33回日本頭頸部癌学会
  • Place of Presentation: 札幌
  • Year and Date: 2009-06-12
• [Remarks] ホームページ等
  • URL: http://www.orl.med.tohoku.ac.jp/
• [Remarks]
  • URL: http://www.orl.med.tohoku.ac.jp/
• [Remarks]
  • URL: http://www.orl.med.tohoku.ac.jp/