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Identification of responsible miRNAs associated with an acquired resistance for cis-diamminedichloroplatinum by microarray analyses in human head and neck squamous cell carcinoma

Research Project

Project/Area Number 21791588
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionTohoku University

Principal Investigator

OGAWA Takenori  Tohoku University, 病院, 助教 (50375060)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords癌 / マイクロアレイ / 薬剤反応性 / 薬剤応答性
Research Abstract

The identification of the resistance-related microRNA clusters was conducted between RPMI2650CR and RPMI2650 using microRNA microarray. Furthermore, clinical study showed that miR34a could be a strong prognostic biomarker of CDDP treated sinonasal squamous cell carcinomas.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (22 results)

All 2011 2010 2009 Other

All Journal Article (12 results) (of which Peer Reviewed: 10 results) Presentation (7 results) Remarks (3 results)

  • [Journal Article] Surgical treatment is recommended for advanced oral squamous cell carcinoma.2011

    • Author(s)
      Ogawa T, Matsuura K, Shiga K, Tateda M, Katagiri K, Kato K, Saijo S, Kobayashi T.
    • Journal Title

      Tohoku J Exp Med. 223-1巻

      Pages: 17-25

    • NAID

      10027806505

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Surgical treatment is recommended for advanced oral squamous cell carcinoma.2011

    • Author(s)
      Ogawa T, Matsuura K, Shiga K, Tateda M, Katagiri K, Kato K, Saijo S, Kobayashi T.
    • Journal Title

      Tohoku J Exp Med.

      Volume: 223 Pages: 17-25

    • NAID

      10027806505

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A cDNA microarray analysis identifies 52 genes associated with CDDP susceptibility in head and neck squamous cell carcinoma cell lines.2010

    • Author(s)
      Ogawa T, Furukawa T, Shiga K, Hashimoto S, Ogawa K, Kobayashi T, Horii A.
    • Journal Title

      EAORL. 267-1巻

      Pages: 123-129

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Survival of a free jejunal graft after the resection of its nutrient vessels.2010

    • Author(s)
      Ogawa T, Matsuura K, Kato K, Sariishi T, Goto T, Matsumoto K, Saijo S.
    • Journal Title

      ANL. 37-1巻

      Pages: 125-128

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of IGF2 (insulin-like growth factor 2) is associated with an acquired resistance for cis-diamminedichloroplatinum in human head and neck squamous cell carcinoma.2010

    • Author(s)
      Ogawa T, Ogawa K, Shiga K, Furukawa T, Nagase H, Hashimoto S, Kobayashi T, Horii A.
    • Journal Title

      EAORL. 267-10巻

      Pages: 1599-1606

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 中咽頭癌133例の臨床統計2010

    • Author(s)
      小川武則, 志賀清人, 鈴木貴博, 加藤健吾, 小林俊光
    • Journal Title

      耳鼻咽喉科展望 53巻

      Pages: 16-17

    • NAID

      130004546328

    • Related Report
      2010 Final Research Report
  • [Journal Article] 早期中咽頭癌(T1、T2)の治療 中咽頭癌に対する化学放射線治療2010

    • Author(s)
      小川武則, 志賀清人, 浅田行紀, 加藤健吾, 松浦一登, 西條茂, 小林俊光
    • Journal Title

      耳鼻と臨床 56巻

      Pages: 12-20

    • Related Report
      2010 Final Research Report
  • [Journal Article] 耳前部より総頸動脈分岐間を通り、下咽頭に穿通した杙創の1例2010

    • Author(s)
      佐藤宏樹, 小川武則, 志賀清人, 大島猛史, 小林俊光
    • Journal Title

      頭頸部外科 20-2巻

      Pages: 135-139

    • NAID

      10029078837

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] ダブル・スコープ法による内視鏡的咽喉頭手術(ELPS)について頭頸部癌2010

    • Author(s)
      松浦一登, 野口哲也, 片桐克則, 今井隆之, 石田英一, 角田梨紗子, 浅田行紀, 小川武則, 加藤健吾, 西條茂
    • Journal Title

      36-4巻

      Pages: 466-472

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of IGF2 (insulin-like growth factor 2) is associated with an acquired resistance for cis-diamminedichloroplatinum in human head and neck squamous cell carcinoma.2010

    • Author(s)
      Ogawa T, Ogawa K, Shiga K, Furukawa T, Nagase H, Hashimoto S, Kobayashi T, Horii A.
    • Journal Title

      Eur Arch Otorhinolaryngol.

      Volume: 267 Pages: 1599-1606

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A cDNA microarray analysis identifies 52 genes associated with cis-dia mminedichloroplatinum susceptibility in head and neck squamous cell carcinoma cell lines2010

    • Author(s)
      Ogawa T, Furukawa T, Shiga K, Hashimoto S, Ogawa K, Kobayashi T, Horii A.
    • Journal Title

      Eur Arch Otorhinolaryngol 267

      Pages: 123-129

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Survival of a free jejunal graft after the resection of its nutrient vessels2010

    • Author(s)
      Ogawa T, Matsuura K, Kato K, Sariishi T, Goto T, Matsumoto K, Saijo S.
    • Journal Title

      Auris Nasus Larynx 37(1)

      Pages: 125-128

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Identification of responsible genes associated with an acquired resistance for cis-diamminedichloroplatinum by microarray analyses of mRNA and miRNA in human head and neck squamous cell carcinoma.2010

    • Author(s)
      Takenori Ogawa, Kiyoto Shiga, Sho Hashimoto, Toshimitsu Kobayashi, Akira Horii
    • Organizer
      IFHNOS2010.
    • Place of Presentation
      Seoul
    • Year and Date
      2010-06-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Identification of responsible genes associated with an acquired resistance for cis-diamminedichloroplatinum by microarray analyses of mRNA and miRNA in human head and neck squamous cell carcinoma2010

    • Author(s)
      Takenori Ogawa, Kiyoto Shiga, Sho Hashimoto, Toshimitsu Kobayashi, Akira Horii
    • Organizer
      IFHNOS2010
    • Place of Presentation
      韓国(ソウル)
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 中咽頭癌に対する化学放射線治療2010

    • Author(s)
      小川武則
    • Organizer
      第15回頭頸部癌化学療法研究会
    • Place of Presentation
      福岡
    • Year and Date
      2010-03-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 中咽頭癌133例の臨床統計2009

    • Author(s)
      小川武則
    • Organizer
      第15回北日本癌治療研究会
    • Place of Presentation
      仙台
    • Year and Date
      2009-10-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 小川武則放射線性頸動脈狭窄を有する下咽頭癌の遊離空腸再建例2009

    • Author(s)
      野口直哉
    • Organizer
      第138回宮城県地方部会
    • Place of Presentation
      仙台
    • Year and Date
      2009-09-05
    • Related Report
      2010 Final Research Report
  • [Presentation] 志賀清人他頭蓋底浸潤した鼻副鼻腔癌に対するTPF同時併用化学放射線治療の治療効果2009

    • Author(s)
      小川武則
    • Organizer
      第21回頭蓋底外科学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-07-03
    • Related Report
      2010 Final Research Report
  • [Presentation] 下咽頭・喉頭局所進行癌に対する化学放射線治療成績の検討2009

    • Author(s)
      小川武則
    • Organizer
      第33回日本頭頸部癌学会
    • Place of Presentation
      札幌
    • Year and Date
      2009-06-12
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.orl.med.tohoku.ac.jp/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.orl.med.tohoku.ac.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.orl.med.tohoku.ac.jp/

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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