Role of ESCRT proteins in the malignant phenotype control of Head and Neck Cancer Cells
| Project/Area Number |
21791589
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Tohoku University |
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Principal Investigator |
KATO Kengo Tohoku University, 病院, 助教 (40455788)
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| Co-Investigator(Renkei-kenkyūsha) |
TANAKA Nobuyuki 宮城県立がんセンター(研究所), 免疫学部, 部長 (60280872)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 酵素 / 蛋白質 / ユビキチン / 小胞輸送 / ESCRT / 頭頸部癌 / 扁平上皮癌 / EMT / 誘導性癌細胞 / 小胞輸送系 |
|---|
| Research Abstract |
Head and Neck Cancer (HNC) originates from the pharynx, and larynx. Improvement in the management, as well as targeted therapy, is required to maintain patients' quality of life and survival. In this study, we investigated how HNC which is linked to EMT is regulated by the ESCRT vesicular transport system. Forced expression of the dominant negative ESCRT regulator, the dominant negative VPS4, in HNC cell lines reduced the cancer stemness phenotype, such as ALDH1 activity. In contrast, cell morphology and motility was not altered. Our results suggest that ESCRT system may control the malignant phenotypes of HNC.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] 化学放射線療法を行う頭頸部がん患者を対象とするクリニカルパスを用いた疼痛管理法 有効性/安全性評価試験2011
Author(s)
加藤健吾, 松浦一登, 全田貞幹, 立花浩之, 本間明宏, 桐田忠昭, 門田伸也, 大田洋二郎, 岩江信法, 大鶴洋, 秋元哲夫, 田原信, 浅井昌大
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Journal Title
頭頸部癌
Volume: 37(1)
Pages: 153-157
NAID
Related Report
Peer Reviewed
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[Journal Article] Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein.2010
Author(s)
Tamai K, Tanaka N, Nakano T, Kakazu E, Kondo Y, Inoue J, Shiina M, Fukushima K, Hoshino T, Sano K, Ueno Y, Shimosegawa T, Sugamura K.
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Journal Title
Biochem Biophys Res Commun 399
Pages: 384-390
Related Report
Peer Reviewed
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[Journal Article] Identification of a high incidence region for retroviral vector integration near exon 1 of the LMO2 locus.2009
Author(s)
Yamada K, Tsukahara T, Yoshino K, Kojima K, Agawa H, Yamashita Y, Amano Y, Hatta M, Matsuzaki Y, Kurotori N, Wakui K, Fukushima Y, Osada R, Shiozawa T, Sakashita K, Koike K, Kumaki S, Tanaka N, Takeshita T.
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Journal Title
Retrovirology 6
Pages: 79-79
NAID
Related Report
Peer Reviewed
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