| Project/Area Number |
21791589
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Tohoku University |
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Principal Investigator |
KATO Kengo Tohoku University, 病院, 助教 (40455788)
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| Co-Investigator(Renkei-kenkyūsha) |
TANAKA Nobuyuki 宮城県立がんセンター(研究所), 免疫学部, 部長 (60280872)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 酵素 / 蛋白質 / ユビキチン / 小胞輸送 / ESCRT / 頭頸部癌 / 扁平上皮癌 / EMT / 誘導性癌細胞 / 小胞輸送系 |
|---|
| Research Abstract |
Head and Neck Cancer (HNC) originates from the pharynx, and larynx. Improvement in the management, as well as targeted therapy, is required to maintain patients' quality of life and survival. In this study, we investigated how HNC which is linked to EMT is regulated by the ESCRT vesicular transport system. Forced expression of the dominant negative ESCRT regulator, the dominant negative VPS4, in HNC cell lines reduced the cancer stemness phenotype, such as ALDH1 activity. In contrast, cell morphology and motility was not altered. Our results suggest that ESCRT system may control the malignant phenotypes of HNC.
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