The role of EGFR vIII for HNSCC invasion and metastasis

• Project/Area Number: 21791590
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Akita University
• Principal Investigator: SUZUKI Shinsuke 秋田大学, 医学部, 講師 (90312701)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 癌 / 頭頸部癌 / EGFR / EMMPRIN / CD147

Research Abstract

This study revealed that EMMPRIN mediates HNSCC tumorigenicity such as MMP expression that induced by EGFR stimulation In addition, the results suggest EMMPRIN induces HNSCC progression by its interaction with Cyclophilin A

Research Products

• [Journal Article] Cyclophilin A-EMMPRIN interaction induces invasion of head and neck squamous cell carcinoma (2012)
  • Author(s): Masafumi Takahashi, Shinsuke Suzuki, Kazuo Ishikawa
  • Journal Title: Oncol Rep Volume: 27 Pages: 198-203
• [Journal Article] Cyclophilin A-EMMPRIN interaction induces invasion of head and neck squamous cell carcinoma (2012)
  • Author(s): Masafumi Takahashi, Shinsuke Suzuki, Kazuo Ishikawa
  • Journal Title: Oncology Report Volume: 27 Pages: 198-203
  • DOI: 10.3892/or.2011.1474
  • Peer Reviewed
• [Presentation] 頭頸部扁平上皮癌におけるEMMPRINとEGFRの関係 (2011)
  • Author(s): 鈴木真輔, 高橋雅史, 石川和夫
  • Organizer: 頭頸部癌学会
  • Place of Presentation: 名古屋
• [Presentation] 頭頸部癌におけるEMMPEINの発現とcyclophilin Aの働き (2011)
  • Author(s): 高橋雅史, 鈴木真輔, 石川和夫
  • Organizer: 頭頸部癌学会
  • Place of Presentation: 名古屋
• [Presentation] Cyclophilin A induces head and neck squamous cell carcinoma (HNSCC) invasion by its interaction to EMMPRIN/CD147 (2011)
  • Author(s): Shinsuke Suzuki, Masafumi Takahashi, Kazuo Ishikawa
  • Organizer: AACR 102^<nd> Annual Meeting 2011 April 2-6
  • Place of Presentation: Orlando FL
• [Presentation] Cyclophilin A induces head and neck squamous cell carcinoma (HNSCC) invasion by its interaction to EMMPRIN/CD147 (2011)
  • Author(s): Shinsuke Suzuki
  • Organizer: AACR 102^<nd> Annual Meeting
  • Place of Presentation: アメリカ合衆国
• [Presentation] EMMPRIN expression is induced by EGFR stimulation in HNSCC (2011)
  • Author(s): Shinsuke Suzuki
  • Organizer: 11^<th> Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
  • Place of Presentation: 兵庫県
• [Presentation] 頭頸部扁平上皮癌におけるEMMPRINとEGFRの関係 (2011)
  • Author(s): 鈴木真輔
  • Organizer: 頭頸部癌学会
  • Place of Presentation: 愛知県
• [Presentation] 頭頸部扁平上皮癌におけるEMMPRIN/CD147の発現とCyclophilin Aの作用 (2010)
  • Author(s): 鈴木真輔
  • Organizer: 日本耳鼻咽喉科学会東北連合会
  • Place of Presentation: 秋田県
  • Year and Date: 2010-07-24
• [Presentation] 頭頸部扁平上皮癌におけるEMMPRIN/CD147の発現とCyclophilin Aの作用 (2010)
  • Author(s): 鈴木真輔
  • Organizer: 日本耳鼻咽喉科学会総会
  • Place of Presentation: 仙台国際センター(宮城県)
  • Year and Date: 2010-05-20
• [Presentation] 頭頸部扁平上皮癌におけるEMMPRIN/CD147の発現とCyclophilin Aの作用 (2010)
  • Author(s): 鈴木真輔, 高橋雅史, 石川和夫
  • Organizer: 第111回日本耳鼻咽喉科学会総会
  • Place of Presentation: 仙台
• [Presentation] 頭頸部扁平上皮癌におけるEMMPRIN/CD147の発現とCyclophilin Aの作用 (2010)
  • Author(s): 鈴木真輔, 高橋雅史, 石川和夫
  • Organizer: 第59回日耳鼻東北地方部会連合学術講演会
  • Place of Presentation: 秋田
• [Presentation] 頭頸部扁平上皮癌細胞の遊走および浸潤に対するEGFRvIIIの関与 (2009)
  • Author(s): 鈴木真輔, S.M. Thomas , S.E. Morgan , J.R. Grandis
  • Organizer: 第33回頭頸部癌学会
  • Place of Presentation: 札幌
• [Presentation] Kazuo Ishikawa 11^<th> Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
  • Author(s): Shinsuke Suzuki, Masafumi Takahashi
  • Organizer: EMMPRIN expression is induced by EGFR stimulation in HNSCC
  • Place of Presentation: Kobe