| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
There is currently no established method for reconstructing temporal bone defects after tympanoplasty or mastoidectomy. Bone tissue reconstruction using tissue engineering techniques is currently receiving attention. This study demonstrated that micro CT devices for animals are very effective for observing bone regeneration. Moreover, of the bone morphogenetic proteins that are capable of forming normal bone, BMP-2 was more efficient at bone formation than PDGF and β-TCP. BMP-2 was shown to have a strong ability to reconstruct bone tissue in temporal bone, and construction of a pneumatic space was confirmed for the first time.
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