The Mechanisms of lymph node metastases in head and neck carcinoma

Research Project

Project/Area Number	21791595
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Otorhinolaryngology
Research Institution	Chiba University
Principal Investigator	CHAZONO Hideaki Chiba University, 医学部附属病院, 助教 (70313806)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000) Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000) Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords	頭頸部癌 / VEGF / 頸部脂肪組織 / リンパ節転移 / 脂肪関連リンパ球集積 / 頸部リンパ節転移
Research Abstract	We focused on the neck fat locating between neck lymph nodes and the primary lesion in patients with head and neck cancer. Fat-Associated Lymphoid Cluster(FALC) was identified in human neck and investigated the relevance of cancer metastasis. These cell populations were significantly reduced by radiation therapy.On the other hand these cells were significant increased in the affected side of the neck and in patients' neck with distant metastasis. FALC might have some relationship to the metastatic ability of head and neck cancer.