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Genetic analysis in head and neck carcinomas in order to establish useful biomarkers

Research Project

Project/Area Number 21791596
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionThe University of Tokyo

Principal Investigator

EBIHARA Yasuhiro  東京大学, 医学部附属病院, 助教 (50422291)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords頭頸部外科学 / 頭頸部腫瘍 / 頭頸部癌 / 遺伝子解析
Research Abstract

To improve the effectiveness of therapies in head and neck squamous cell carcinomas(HNSCCs), it is important to identify biomarkers related to clinical gain. In this research, we found dominancy of nonsense mutations in Japanese HNSCCs compared with other previous reports in the world. However, EGFR mutations, EGFR variant type III, ALK mutations, EML4-ALK fusions were not found in all the cases.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (5 results)

All 2012 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results)

  • [Journal Article] 頭頸部癌におけるTP53・EGFR遺伝子異常の解析2011

    • Author(s)
      蝦原康宏、岩井美和子、吉田昌史、安藤瑞生、朝蔭孝宏、山岨達也、村上善則
    • Journal Title

      頭頸部癌

      Volume: 37巻 Pages: 1-6

    • NAID

      10030814670

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 頭頸部癌におけるTP53・EGFR遺伝子異常の解析2011

    • Author(s)
      蝦原康宏
    • Journal Title

      頭頸部癌

      Volume: 37 Pages: 1-6

    • NAID

      10030814670

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Genetic analysis of the TP53 and EGFR genes in head and neck squamous cell carcinomas in Japanese patients2012

    • Author(s)
      Yasuhiro Ebihara
    • Organizer
      The 14^<th> Japan-Korea Joint meeting of Otorhinolaryngology-Head and neck surgery
    • Place of Presentation
      Kyoto
    • Year and Date
      2012-04-13
    • Related Report
      2011 Final Research Report
  • [Presentation] 頭頸部癌におけるTP53・EGFR遺伝子異常の解析2010

    • Author(s)
      蝦原康宏
    • Organizer
      第34回日本頭頸部癌学会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-10
    • Related Report
      2011 Final Research Report
  • [Presentation] 頭頸部癌におけるTP53・EGFR遺伝子異常の解析2010

    • Author(s)
      蝦原康宏
    • Organizer
      第34回 日本頭頸部癌学会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-10
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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