Basical study for regulation of apoptosis; Aiming to improve the results and to enlarge the application of cochlear implant surgery.
| Project/Area Number |
21791597
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
KASHIO Akinori The University of Tokyo, 医学部附属病院, 助教 (20451809)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | アポトーシス / 人工内耳 / ウロキナーゼ / タンパク治療 / アミノ配糖体 / 有毛細胞 / 内耳 / PTD-FNK / 蛋白治療 |
|---|
| Research Abstract |
Urokinase-type plasminogen activator (uPA) and its receptor (uPAR) are recently shown to have close relationship to the apoptosis. We demonstrated that uPAR was in the cochlea especially in organ of corti and spiral ganglion, which is indicating that the uPA-uPAR anti-apoptotic system is working in cochlea. Next we demonstrated, using cochlear organotypic cultures of the rat, that uPA attenuates the aminoglicoside induced apoptotic hair cell death in a dose dependent manner. We have also demonstrated that artificial anti-apototic protein PTD-FNK attenuates the aminoglicoside induced apoptotic hair cell death by affecting caspase-9 related mitochondrial apoptotic pathway.
|
Report
(3 results)
Research Products
(27 results)
-
[Journal Article] Carhart's notch, a 2kHz bone conduction threshold dip, is not a definitive predictor of stapes fixation in conductive hearing loss accompanied with a normal ear drum.2011
Author(s)
Kashio A, Ito K, Kakigi A, Karino S, Iwasaki S, Sakamoto T, Yasui T, Suzuki M, Yamasoa T.
-
Journal Title
Arch Otolaryngol Head Neck Surg 137(3)
Pages: 236-240
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Ocular vestibular-evoked myogenic potentials (oVEMPs) require extraocular muscles but not facial or cochlear nerve activity.2009
Author(s)
Chihara Y, Iwasaki S, Ushio M, Fujimoto C, Kashio A, Kondo K, Ito K, Asakage T, Yamasoba T, Kaga K, Murofushi T.
-
Journal Title
Clin Neurophysiol. 120(3)
Pages: 581-587
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
