The expression of B7-H3 costimulating factor in head and neck cancer
| Project/Area Number |
21791605
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
MORIYAMA Motohiro 山梨大学, 大学院・医学工学総合研究部, 助教 (00402074)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 頭頸部外科学 / 共刺激分子 / B7-H3 / 免疫抑制 / 頭頸部扁平上皮癌 |
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| Research Abstract |
We examined the role of B7-H3, which in the co-stimulating factor of B7 family, activated T lymphocyte in Head and Neck carcinoma. We verified the expression of B7-H3 slightly on Ca9-22 cell line of oral squamous cell carcinoma. CD44+cells are population of cancer stem like cells. I compared the B7-H3 expression on CD44+cell with CD44-cells. Moreover, we confirmed the expression of CD44 variant form is higher than CD44 standard form on Ca9-22. Ca9-22 hadn' t produced most of the TGF-beta.
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Report
(4 results)
Research Products
(23 results)
