The immunosuppressive role of MDSC in microenvironment of head and neck cancer
| Project/Area Number |
21791606
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 頭頸部外科学 / MDSC / 免疫抑制 / CD14+HLA-DR+ / 制御性T細胞 / CD14+HLA-DR- / TGF-β / 腫瘍微小環境 |
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| Research Abstract |
Myeloid-derived suppressor cells(MDSC) represent a heterogeneous population and have the potential to suppress immuneresponses via diverse mechanisms. MDSC was identified by the markers HLA-DR in theperipheral blood from cancer patients. In this study, we investigated the proportions and characteristics of CD14+HLA-DR_cells in patients with squamous cell carcinoma of the head and neck(SCCHN). The sorted CD14+HLA-DR_cells were able to suppress effectively both the proliferation and IFN-c production of anti-CD28 stimulated T cells, suggesting that CD14+HLA-DR_cells act as potent immunosuppressive cells and particularly contribute to tumor escape from the host immune system in patients with SCCHN.
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Report
(4 results)
Research Products
(8 results)
