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The immunosuppressive role of MDSC in microenvironment of head and neck cancer

Research Project

Project/Area Number 21791606
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionUniversity of Yamanashi

Principal Investigator

YAMAMOTO Takanori  山梨大学, 医学部・附属病院, 助教 (60436863)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords頭頸部外科学 / MDSC / 免疫抑制 / CD14+HLA-DR+ / 制御性T細胞 / CD14+HLA-DR- / TGF-β / 腫瘍微小環境
Research Abstract

Myeloid-derived suppressor cells(MDSC) represent a heterogeneous population and have the potential to suppress immuneresponses via diverse mechanisms. MDSC was identified by the markers HLA-DR in theperipheral blood from cancer patients. In this study, we investigated the proportions and characteristics of CD14+HLA-DR_cells in patients with squamous cell carcinoma of the head and neck(SCCHN). The sorted CD14+HLA-DR_cells were able to suppress effectively both the proliferation and IFN-c production of anti-CD28 stimulated T cells, suggesting that CD14+HLA-DR_cells act as potent immunosuppressive cells and particularly contribute to tumor escape from the host immune system in patients with SCCHN.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (8 results)

All 2012 2011 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (4 results)

  • [Journal Article] Immunosuppressive activity of CD14+HLA-DR-cells in squamous cell carcinoma of the head and neck2012

    • Author(s)
      Kazuaki Chikamatsu, Koichi Sakakura, Minoru Toyoda, Katsumasa Takahashi, Takanori Yamamoto, Masuyama Keisuke
    • Journal Title

      Cancer Research

      Volume: 103(6) Pages: 976-83

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunosuppressive activity of CD 14+ HLA-DR_cells in squamous cell carcinoma of the head and neck2012

    • Author(s)
      Kazuaki Chikamatsu, et al
    • Journal Title

      Cancer science

      Volume: (In press) Issue: 6 Pages: 976-983

    • DOI

      10.1111/j.1349-7006.2012.02248.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of Helper T Cell Responses to Cry J 1-Derived Peptides in Patients with Nasal Allergy2009

    • Author(s)
      Masuyama K, Chikamatsu K, Ikagawa S, Matsuoka T, Takahashi G, Yamamoto T, Endo S
    • Journal Title

      Candidate for Peptide-Based Immunotherapy of Japanese Cedar Pollinosis Allergology International

      Volume: 58(1) Pages: 63-70

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of helper T cell responses to Cry j 1-derived peptides in patients with nasal allergy : candidate for peptide-based immunotherapy of Japanese cedar pollinosis.2009

    • Author(s)
      Masuyama K, et al.
    • Journal Title

      Allergol Int 58

      Pages: 63-70

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 頭頸部扁平上皮癌患者の免疫抑制に及ぼすmyeloid-derived suppressor cellの役割2011

    • Author(s)
      近松一朗, 他
    • Organizer
      第29回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      大分
    • Related Report
      2010 Annual Research Report
  • [Presentation] スギ花粉症に対するボツリヌス治療の有効性の検討(E-BOAT Study 2)2010

    • Author(s)
      上條篤, 他
    • Organizer
      第49回日本鼻科学会
    • Place of Presentation
      札幌
    • Related Report
      2010 Annual Research Report
  • [Presentation] A case of idiopathic hypereosinophilic syndrome with sinusitis and granulation tissue in the pharynx.2009

    • Author(s)
      Yamamoto T, et al.
    • Organizer
      Rhinology World 2009
    • Place of Presentation
      Philadelphia, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] 後天性後鼻孔閉鎖の1症例とその手術経験2009

    • Author(s)
      上條篤, 他
    • Organizer
      第71回耳鼻咽喉科臨床学会
    • Place of Presentation
      旭川
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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