The immunosuppressive role of MDSC in microenvironment of head and neck cancer

• Project/Area Number: 21791606
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: University of Yamanashi
• Principal Investigator: YAMAMOTO Takanori 山梨大学, 医学部・附属病院, 助教 (60436863)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 頭頸部外科学 / MDSC / 免疫抑制 / CD14+HLA-DR+ / 制御性T細胞 / CD14+HLA-DR- / TGF-β / 腫瘍微小環境

Research Abstract

Myeloid-derived suppressor cells(MDSC) represent a heterogeneous population and have the potential to suppress immuneresponses via diverse mechanisms. MDSC was identified by the markers HLA-DR in theperipheral blood from cancer patients. In this study, we investigated the proportions and characteristics of CD14+HLA-DR_cells in patients with squamous cell carcinoma of the head and neck(SCCHN). The sorted CD14+HLA-DR_cells were able to suppress effectively both the proliferation and IFN-c production of anti-CD28 stimulated T cells, suggesting that CD14+HLA-DR_cells act as potent immunosuppressive cells and particularly contribute to tumor escape from the host immune system in patients with SCCHN.

Research Products

• [Journal Article] Immunosuppressive activity of CD14+HLA-DR-cells in squamous cell carcinoma of the head and neck (2012)
  • Author(s): Kazuaki Chikamatsu, Koichi Sakakura, Minoru Toyoda, Katsumasa Takahashi, Takanori Yamamoto, Masuyama Keisuke
  • Journal Title: Cancer Research Volume: 103(6) Pages: 976-83
  • Peer Reviewed
• [Journal Article] Immunosuppressive activity of CD 14+ HLA-DR_cells in squamous cell carcinoma of the head and neck (2012)
  • Author(s): Kazuaki Chikamatsu, et al
  • Journal Title: Cancer science Volume: (In press) Issue: 6 Pages: 976-983
  • DOI: 10.1111/j.1349-7006.2012.02248.x
  • Peer Reviewed
• [Journal Article] Analysis of Helper T Cell Responses to Cry J 1-Derived Peptides in Patients with Nasal Allergy (2009)
  • Author(s): Masuyama K, Chikamatsu K, Ikagawa S, Matsuoka T, Takahashi G, Yamamoto T, Endo S
  • Journal Title: Candidate for Peptide-Based Immunotherapy of Japanese Cedar Pollinosis Allergology International Volume: 58(1) Pages: 63-70
  • Peer Reviewed
• [Journal Article] Analysis of helper T cell responses to Cry j 1-derived peptides in patients with nasal allergy : candidate for peptide-based immunotherapy of Japanese cedar pollinosis. (2009)
  • Author(s): Masuyama K, et al.
  • Journal Title: Allergol Int 58 Pages: 63-70
  • Peer Reviewed
• [Presentation] 頭頸部扁平上皮癌患者の免疫抑制に及ぼすmyeloid-derived suppressor cellの役割 (2011)
  • Author(s): 近松一朗, 他
  • Organizer: 第29回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 大分
• [Presentation] スギ花粉症に対するボツリヌス治療の有効性の検討(E-BOAT Study 2) (2010)
  • Author(s): 上條篤, 他
  • Organizer: 第49回日本鼻科学会
  • Place of Presentation: 札幌
• [Presentation] A case of idiopathic hypereosinophilic syndrome with sinusitis and granulation tissue in the pharynx. (2009)
  • Author(s): Yamamoto T, et al.
  • Organizer: Rhinology World 2009
  • Place of Presentation: Philadelphia, USA
• [Presentation] 後天性後鼻孔閉鎖の1症例とその手術経験 (2009)
  • Author(s): 上條篤, 他
  • Organizer: 第71回耳鼻咽喉科臨床学会
  • Place of Presentation: 旭川