Screening of Age-related hearing impairment-responsible genes and their functional analysis.

Research Project

Project/Area Number	21791609
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Otorhinolaryngology
Research Institution	Shinshu University
Principal Investigator	HASHIMOTO Shigenari 信州大学, 医学系研究科, 助教 (90359729)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	老化 / 難聴 / SNP / 熟年 / データベース / インターバル速歩 / 内耳 / 老人性難聴 / 遺伝子 / SNPs / 高音障害型感音難聴 / 遺伝子発現パターン / レーザーマイクログイセクション / SAMマウス
Research Abstract	We have obtained significant difference of hearing in high-frequency between 70' years old persons for their SNPs genotype of COCH, encoding In addition, SNPs in MyosinVIIa(Myo7a) showed the strong involvement in ARHI. These results suggest that COCH and Myo7a are novel factors, which do not play a role in congenital hearing impairment but play a role in acquired hearing disease such as ARHI. Further studying will be necessary to confirm our finding and for their functional role in ARHI.

Report

(4 results)