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Basic research for denervation and aberrant nerve reinnervation in aged animal models

Research Project

Project/Area Number 21791624
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionKumamoto University

Principal Investigator

MIYAMARU Satoru  Kumamoto University, 大学院・生命科学研究部, 助教 (10535636)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords加齢 / 脱神経 / 反回神経麻痺 / 神経再支配 / 神経筋弁移植 / 神経筋弁移植術 / 神経筋接合部 / 筋電図
Research Abstract

We evaluated the effects of reinnervation procedures on the denervated thyroarytenoid (TA) muscle in aged rats. For the reinnervation procedure, we implanted the nerve-muscle pedicle (NMP), the ansa cervicalis nerve branch with a piece of sternohyoid muscle, in the denervated TA muscle. The NMP method could recover the denervation atrophy of TA muscle and the denervated TA muscle was reinnervated through the transferred ansa cervicalis nerve. We confirmed that the reinnervation procedures, by use of other nerves could recover the atrophic changes of the denervated muscles even in aged models.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (2 results)

All 2010

All Presentation (2 results)

  • [Presentation] 脱神経後の甲状披裂筋への神経筋弁移植術の加齢による影響2010

    • Author(s)
      宮丸悟、熊井良彦、讃岐徹治、湯本英二
    • Organizer
      第111回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2010-05-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 脱神経後の甲状披裂筋への神経筋弁移植術の加齢による影響2010

    • Author(s)
      宮丸悟
    • Organizer
      第111回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      仙台市 仙台国際センター
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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