Altered expression of tight junctions in nasopharyngeal and oropharyngeal carcinoma of EMT in EBV or HPV infection
| Project/Area Number |
21791628
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
TAKANO Kenichi Sapporo Medical University, 医学部, 助教 (70404689)
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| Research Collaborator |
HIMI Tetsuo 札幌医科大学, 医学部, 教授 (90181114)
SAWADA Norimasa 札幌医科大学, 医学部, 教授 (30154149)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 咽頭癌 / EMT / タイト結合 |
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| Research Abstract |
In human oropharyngeal squamous cell carcinoma, the expression of claudin-7 and tricellulin was weak or absent, whereas claudin-1 was observed strong expression. We observed that claudin-1 was stronger expression at the invasive front, this suggests the interaction between expression of tight junctions and EMT. There were not significant relationships between the tight junction expressions and HPV status.
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] Altered expression of claudin-1, claudin-7, and tricellulin regardless of human papilloma virus infection in human tonsillar squamous cell carcinoma.2011
Author(s)
Kondoh A, Takano K, Kojima T, Ohkuni T, Kamekura R, Ogasawara N, Go M, Sawada N, Himi T
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Journal Title
Acta Otolaryngol. inpress
Related Report
Peer Reviewed
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[Journal Article] Epithelial barrier and antigen uptake in lymphoepithelium of human adenoids.2011
Author(s)
Ogasawara N, Kojima T, Go M, Takano K, Kamekura R, Ohkuni T, Koizumi J, Masaki T, Fuchimoto J, Obata K, Kurose M, Shintani T, Sawada N, Himi T.
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Journal Title
Acta Otolaryngol. 131
Pages: 116-123
Related Report
Peer Reviewed
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[Journal Article] Thymic stromal lymphopoietin induces tight junction protein claudin-7 via NF-kappaB in dendritic cells.2010
Author(s)
Kamekura R, Kojima T, Takashima A, Koizumi J, Ogasawara N, Go M, Takano K, Murata M, Tanaka S, Ichimiya S, Himi T, Sawada N.
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Journal Title
Histochem Cell Biol. 133
Pages: 339-348
Related Report
Peer Reviewed
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