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Altered expression of tight junctions in nasopharyngeal and oropharyngeal carcinoma of EMT in EBV or HPV infection

Research Project

Project/Area Number 21791628
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionSapporo Medical University

Principal Investigator

TAKANO Kenichi  Sapporo Medical University, 医学部, 助教 (70404689)

Research Collaborator HIMI Tetsuo  札幌医科大学, 医学部, 教授 (90181114)
SAWADA Norimasa  札幌医科大学, 医学部, 教授 (30154149)
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords咽頭癌 / EMT / タイト結合
Research Abstract

In human oropharyngeal squamous cell carcinoma, the expression of claudin-7 and tricellulin was weak or absent, whereas claudin-1 was observed strong expression. We observed that claudin-1 was stronger expression at the invasive front, this suggests the interaction between expression of tight junctions and EMT. There were not significant relationships between the tight junction expressions and HPV status.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (27 results)

All 2011 2010 2009

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (11 results)

  • [Journal Article] A novel concept of Mikulicz's disease as IgG4-related disease2011

    • Author(s)
      Himi T, Takano K, Yamamoto M, Naishiro Y, Takahashi H
    • Journal Title

      Auris Nasus Larynx in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered expression of claudin-1, claudin-7, and tricellulin regardless of human papilloma virus infection in human tonsillar squamous cell carcinoma.2011

    • Author(s)
      Kondoh A, Takano K, Kojima T, Ohkuni T, Kamekura R, Ogasawara N, Go M, Sawada N, Himi T
    • Journal Title

      Acta Otolaryngol. inpress

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A well-differentiated liposarcoma of the hypopharynx.2011

    • Author(s)
      Takano K, Kondoh A, Matsumiya H, Himi T.
    • Journal Title

      Otolaryngol Head Neck Surg 144

      Pages: 479-480

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epithelial barrier and antigen uptake in lymphoepithelium of human adenoids.2011

    • Author(s)
      Ogasawara N, Kojima T, Go M, Takano K, Kamekura R, Ohkuni T, Koizumi J, Masaki T, Fuchimoto J, Obata K, Kurose M, Shintani T, Sawada N, Himi T.
    • Journal Title

      Acta Otolaryngol. 131

      Pages: 116-123

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case of reversible hyposmia associated with Mikulicz's disease.2011

    • Author(s)
      (10)Takano K, Yamamoto M, Kondo A, Himi T
    • Journal Title

      Otolaryngol Head Neck Surg. 141(3)

      Pages: 430-431

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A well-differentiated liposarcoma of the hypopharynx.2011

    • Author(s)
      Takano K, Kondoh A, Matsumiya H, Himi T.
    • Journal Title

      Otolaryngol Head Neck Surg

      Volume: 144 Pages: 479-480

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A clinical study of olfactory dysfunction in patients with Mikulicz's disease.2011

    • Author(s)
      Takano K, Yamamoto M, Kondo A, Takahashi H, Himi T.
    • Journal Title

      Auris Nasus Larynx

      Volume: 38 Pages: 347-351

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thymic stromal lymphopoietin induces tight junction protein claudin-7 via NF-kappaB in dendritic cells.2010

    • Author(s)
      Kamekura R, Kojima T, Takashima A, Koizumi J, Ogasawara N, Go M, Takano K, Murata M, Tanaka S, Ichimiya S, Himi T, Sawada N.
    • Journal Title

      Histochem Cell Biol. 133

      Pages: 339-348

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathologic similarities between Mikulicz disease and Kuttner tumor.Am J Otolaryngol2010

    • Author(s)
      (6)Takano K, Yamamoto M, Takahashi H, Shinomura Y, Imai K, Himi T.
    • Journal Title

      31

      Pages: 429-434

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathologic similarities between Mikulicz disease and Kuttner tumor.2010

    • Author(s)
      Takano K, Yamamoto M, Takahashi H, Shinomura Y, Imai K, Himi T.
    • Journal Title

      Am J Otolaryngol

      Volume: 31 Pages: 429-434

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ミクリッツ病に合併する嗅覚障害に関する検討2010

    • Author(s)
      高野賢一, 山本元久, 亀倉隆太, 松宮弘, 氷見徹夫
    • Journal Title

      日鼻誌

      Volume: 49 Pages: 121-126

    • NAID

      10026432424

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression and localization of tricellulin in human nasal epithelial cells in vivo and in vitro.2009

    • Author(s)
      (7)Ohkuni T, Kojima T, Ogasawara N, Masaki T, Ninomiya T, Kikuchi S, Go M, Takano K, Himi T, Sawada N.
    • Journal Title

      Med Mol Morphol. 22

      Pages: 204-211

    • NAID

      10027269508

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case of reversible hyposmia associated with Mikulicz's disease.2009

    • Author(s)
      (8)Takano K, Yamamoto M, Kondo A, Himi T.
    • Journal Title

      Otolaryngol Head Neck Surg. 141

      Pages: 430-431

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological characteristics of Mikulicz's disease and Kuttner's tumor Oral Med Pathol 142009

    • Author(s)
      Himi T, Takano K, Kondo A, Kamekura R, Obata K, Yamamoto M, Takahashi H
    • Pages
      41-47
    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case of reversible hyposmia associated with Mikulicz's disease2009

    • Author(s)
      Takano K
    • Journal Title

      Otolaryngology-Head&Neck Surgery 141(3)

      Pages: 430-431

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological characteristics of Mikuliz's disease and Kuttner's tomor2009

    • Author(s)
      Himi T
    • Journal Title

      Oral Med Pathol 14

      Pages: 41-47

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ミクリッツ病における顎下腺の病理組織学的検討2011

    • Author(s)
      高野賢一
    • Organizer
      第28回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      福井
    • Year and Date
      2011-02-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] ミクリッツ病における顎下腺の病理組織学的検討2010

    • Author(s)
      高野賢一
    • Organizer
      第23回日本口腔・咽頭科学会総会ならびに学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] M-Like Cells of Human Adenoids in Vivo and in Vitro.2010

    • Author(s)
      Takano K
    • Organizer
      The 7th International Symposium on Tonsils and Mucosal Barriers of the Upper Airways.
    • Place of Presentation
      Asahikawa, Japan
    • Year and Date
      2010-07-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] ミクリッツ病における顎下腺の組織学的検討2010

    • Author(s)
      山本元久, 苗代康可, 氷見徹夫
    • Organizer
      第23回日本口腔・咽頭科学会総会ならびに学術講演会
    • Place of Presentation
      東京都
    • Related Report
      2010 Final Research Report
  • [Presentation] M-Like Cells of Human Adenoids in Vivo and in Vitro. Tonsils and Mucosal Barriers of the Upper Airways2010

    • Author(s)
      Noriko Ogasawara, Mitsuru Go, Shin Kikuchi, Takafumi Ninomiya, Makoto Kurose, Jun-ichi Koizumi, Ryuta Kamekura, Norimasa Sawda, Tetsuo Himi.
    • Organizer
      The 7th International Symposium on .
    • Place of Presentation
      Asahikawa, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] ミクリッツ病における顎下腺の病理組織学的検討2010

    • Author(s)
      高野賢一, 亀倉隆太, 近藤敦, 氷見徹夫
    • Organizer
      第28回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      福井市
    • Related Report
      2010 Final Research Report
  • [Presentation] 中咽頭扁平上皮癌におけるタイト結合蛋白の発現変化の検討2009

    • Author(s)
      近藤敦
    • Organizer
      第22回日本口腔・咽頭科学会
    • Place of Presentation
      和歌山市
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] ミクリッツ病における病理組織学的検討2009

    • Author(s)
      高野賢一
    • Organizer
      第22回日本口腔・咽頭科学会
    • Place of Presentation
      和歌山市
    • Year and Date
      2009-09-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] ミクリッツ病における病理組織学的検討2009

    • Author(s)
      )高野賢一, 氷見徹夫
    • Organizer
      第22回日本口腔・咽頭科学会
    • Place of Presentation
      和歌山
    • Related Report
      2010 Final Research Report
  • [Presentation] 急性散在性脳脊髄炎症例におけるABRの検討2009

    • Author(s)
      高野賢一, 吉岡巌, 佐藤純, 氷見徹夫
    • Organizer
      第4回日本小児耳鼻咽喉科学会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] ミクリッツ病における嗅覚障害の検討2009

    • Author(s)
      高野賢一, 山本元久, 氷見徹夫
    • Organizer
      第27回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      千葉
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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