The study of auditory skill and speech development in sensorineural hearing loss with congenital cytomegalovirus infection

• Project/Area Number: 21791630
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Fukushima Medical University
• Principal Investigator: MATSUI Takamichi 福島県立医科大学, 医学部, 講師 (40404876)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ウイルス / 感染症 / 聴覚障害 / 言語発達 / 人工内耳 / サイトメガロウイルス / 発達

Research Abstract

Five children with congenital CMV infection-related SNHL, underwent cochlear implantation. Hearing level and speech and language development were evaluated post-implantation using IT-MAIS, MUSS, and S-S method. Congenital CMV infection was confirmed in five patients before surgery by the preparation of DNAs-pecimens from samples of their dried umbilical cords followed by a nested PCR for detection of the CMV glycoprotein H gene. All children showed development in auditory skills and language comprehension and speech production following cochlear implantation. The results of the present study suggest that the use of cochlear implantation is appropriate for patients with SNHL associated with asymptomatic CMV infection.

Research Products

• [Journal Article] Outcome of cochlear implantation in children with congenital cytomegalovirus infection and GJB2 mutation in relation to developmental disorder (2012)
  • Author(s): Matsui T, Imamura T, Suzutani T, Ogawa H, Asano K, Nomoto M, , Ogawa H, Yamada N, Baba Y, Suzuki Y, Nomoto M, Suzutani T, Omori K.
  • Journal Title: Acta Oto-Laryngologica Volume: 132 Pages: 597-602
  • Peer Reviewed
• [Journal Article] Oral valganciclovir treatment for congenital cytomegalovirus infection (2011)
  • Author(s): Imamura T, Suzutani T, Ogawa H, Asano K, Nomoto M, Matsui T, Momoi N, et. al
  • Journal Title: Pediatrics International Volume: 53 Pages: 249-252
  • NAID: 10029557994
  • Peer Reviewed
• [Journal Article] 【重複障害のある難聴児への聴覚言語獲得支援】障害の評価と補聴器・人工内耳の適応 (2010)
  • Author(s): 小川洋, 馬場陽子, 山田奈保子, 鈴木雪恵, 松井隆道, 野本美香, 小針香菜, 鈴木綾, 村岡理恵, 佐場野優一, 大森孝一
  • Journal Title: 音声言語医学 Volume: 51巻2号 Pages: 199-202
• [Journal Article] 障害の評価と補聴器・人工内耳の適応 (2010)
  • Author(s): 小川洋
  • Journal Title: 音声言語医学 Volume: 51 Pages: 199-202
• [Presentation] 当科における小児人工内耳の成績:先天性サイトメガロウイルス感染とGJB2遺伝子変異症例について (2011)
  • Author(s): 松井隆道
  • Organizer: 第21回日本耳科学会
  • Place of Presentation: 沖縄
  • Year and Date: 2011-11-26
• [Presentation] 当科における小児人工内耳の成績:先天性サイトメガロウイルス感染とGJB2遺伝子変異症例について (2011)
  • Author(s): 松井隆道
  • Organizer: 日本耳科学会
  • Place of Presentation: 沖縄県宜野湾市
  • Year and Date: 2011-11-26
• [Presentation] Outcome of cochlear implantation in children with congenital cytomegal ovirus infection and GJB2 mutation in relation to developmental disorder (2011)
  • Author(s): 松井隆道
  • Organizer: COSM (The Combined Otolaryngology Spring Meetings)
  • Place of Presentation: 米国シカゴ
  • Year and Date: 2011-04-30
• [Presentation] Outcome of cochlear implantation in children with congenital cytomegalovirus infection and GJB2 mutation in relation to developmental disorder (2011)
  • Author(s): Matsui. T, Ogawa H, et. al
  • Organizer: The Combined Otolaryngology Spring Meetings Triological Society
  • Place of Presentation: 米国シカゴ
  • Year and Date: 2011-04-29
• [Presentation] Effectiveness of cochlear implantation in children with sensorineural hearing loss : Comparison of congenital cytomegalovirus infection and GJB2 mutation (2010)
  • Author(s): Matsui. T, Ogawa H, et. al
  • Organizer: Sixth International Symposium on Meniere's Disease and Inner Ear Disorders
  • Place of Presentation: 京都
  • Year and Date: 2010-11-15
• [Presentation] Effectiveness of cochlear implantation in children with sensorineural hearing loss : Comparison of congenital cytomegalovirus infection and GJB2 mutation. (2010)
  • Author(s): 松井隆道
  • Organizer: Sixth International Symposium on Meniere's Disease and Inner Ear Disorders
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2010-11-15
• [Presentation] 当科における小児人工内耳の成績 (2010)
  • Author(s): 松井隆道
  • Organizer: 第20回日本耳科学会
  • Place of Presentation: 愛媛
  • Year and Date: 2010-10-08
• [Presentation] 当科における小児人工内耳の成績 (2010)
  • Author(s): 松井隆道
  • Organizer: 第20回日本耳科学会
  • Place of Presentation: 愛媛県松山市
  • Year and Date: 2010-10-08