| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
We have demonstrated that IL-21 and IL-27 suppress SCCVII tumor growth(J. Gene Med 2006).
In 2010, we investigated the mechanisms of antitumor immunity elicited by IL-27 gene transfer. The results shows that IL-27 gene transfer augmented cytotoxic activity of NK cells.
Furthermore, we demonstrated antitumor effect induced be IL-21 or IL-27 gene transfer was enhanced by electrochemotherapy with CDDP.
In 2011, we have reported that IL-28 acts synergistically with CDDP to suppress the growth of SCCVII(J. immunother 2011).
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