Cytokine Immuno-gene Therapy Against Head and Neck Squamous Cell Carcinoma
| Project/Area Number |
21791632
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
NAKANO Hiroshi 京都府立医科大学, 医学研究科, 助教 (00405309)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 頭頸部外科学 / 頭頸部癌 / サイトカイン / インターロイキン / 免疫遺伝子治療 / 抗癌剤 |
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| Research Abstract |
We have demonstrated that IL-21 and IL-27 suppress SCCVII tumor growth(J. Gene Med 2006).
In 2010, we investigated the mechanisms of antitumor immunity elicited by IL-27 gene transfer. The results shows that IL-27 gene transfer augmented cytotoxic activity of NK cells.
Furthermore, we demonstrated antitumor effect induced be IL-21 or IL-27 gene transfer was enhanced by electrochemotherapy with CDDP.
In 2011, we have reported that IL-28 acts synergistically with CDDP to suppress the growth of SCCVII(J. immunother 2011).
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Interleukin-28B acts synergistically with cisplatin to suppress the growth of head and neck squamous cell carcinoma2011
Author(s)
Yoshimoto K, Kishida T, Nakano H, Matsui M, Shin-Ya M, Shimada T, Nakai S, Imanishi J, Takeuchi M, Hisa Y, Mazda O
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Journal Title
J immunother
Volume: 34
Pages: 139-148
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