| Project/Area Number |
21791634
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
SAKAGUCHI Hirofumi Kyoto Prefectural University of Medicine, 医学研究科, 助教 (00515223)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 聴覚 / 内耳 / 蝸牛 / 有毛細胞 / tip link / カドヘリン / cadherin 23 / protocadherin / tip lin / 不動毛 / 再生 / 機械電気変換 |
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| Research Abstract |
In the current study, we observed regeneration process of tip link, a key player for the mechanotransduction in inner ear hair cells, and showed its possible spontaneous regeneration in mammal, as same as previously shown in avian. Our data also suggested the difference in the regeneration potential between inner and outer hair cells. Moreover, we demonstrated that the morphology of the apical surface in outer hair cells achieves its specific shape during the period of the tip link maturation.
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