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Research in the metabolic dynamics of the molecular component of the tip link, essential structure for hearing reception

Research Project

Project/Area Number 21791634
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

SAKAGUCHI Hirofumi  Kyoto Prefectural University of Medicine, 医学研究科, 助教 (00515223)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords聴覚 / 内耳 / 蝸牛 / 有毛細胞 / tip link / カドヘリン / cadherin 23 / protocadherin / tip lin / 不動毛 / 再生 / 機械電気変換
Research Abstract

In the current study, we observed regeneration process of tip link, a key player for the mechanotransduction in inner ear hair cells, and showed its possible spontaneous regeneration in mammal, as same as previously shown in avian. Our data also suggested the difference in the regeneration potential between inner and outer hair cells. Moreover, we demonstrated that the morphology of the apical surface in outer hair cells achieves its specific shape during the period of the tip link maturation.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (10 results)

All 2010 2009

All Journal Article (6 results) Presentation (4 results)

  • [Journal Article] 発生期コルチ器における頂側結合の経時的変化2010

    • Author(s)
      藤田朋己、瀧正勝、坂口博史、鈴木敏弘、米村重信、久育男
    • Journal Title

      Otology Japan. 20(4)

      Pages: 539-539

    • Related Report
      2010 Final Research Report
  • [Journal Article] 有毛細胞感覚糸(Tip Link)の再生と細胞頂側面形態形成への関与について2010

    • Author(s)
      坂口博史
    • Journal Title

      上原記念生命化学財団研究報告集 24

      Pages: 155-155

    • Related Report
      2010 Final Research Report
  • [Journal Article] 有毛細胞感覚糸(Tip Link)の再生と細胞頂側面形態形成への関与について2010

    • Author(s)
      坂口博史
    • Journal Title

      上原記念生命化学財団研究報告集

      Volume: 24 Pages: 155-155

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 発生期コルチ器における頂側結合の経時的変化2010

    • Author(s)
      藤田朋己, 瀧正勝, 坂口博史, ら
    • Journal Title

      Otology Japan

      Volume: 2(4) Pages: 539-539

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Tip links in hair cells : molecular composition and role in hearing loss.2009

    • Author(s)
      Sakaguchi H, Tokita J, Muller U, Kachar B.
    • Journal Title

      Curr Opin Otolaryngol Head Neck Surg 17

      Pages: 388-393

    • Related Report
      2010 Final Research Report
  • [Journal Article] The Mechanotransduction machinery of hair cells.2009

    • Author(s)
      Grillet N, Kazmierczak P, Xiong W, Shwander M, Reynolds A, Sakaguchi H, Tokita J, Kachar B, Muller U.
    • Journal Title

      Sci Signal 2

      Pages: 5-5

    • Related Report
      2010 Final Research Report
  • [Presentation] 発生期コルチ器における頂側結合の経時的変化2010

    • Author(s)
      藤田朋己、瀧正勝、坂口博史、鈴木敏弘、米村重信、久育男
    • Organizer
      日本耳科学会学術講演会
    • Place of Presentation
      松山
    • Year and Date
      2010-10-08
    • Related Report
      2010 Final Research Report
  • [Presentation] 発生期コルチ器におけろ頂側結合の経時的変化2010

    • Author(s)
      藤田朋己, 瀧正勝, 坂口博史, ら
    • Organizer
      日本耳科学会学術講演会
    • Place of Presentation
      松山
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Morphological Development of the Reticular Lamina in the Perinatal and Postnatal Mouse.2010

    • Author(s)
      Fujita T, Sakaguchi H, Suzuki T, Hisa Y, Yonemura S.
    • Organizer
      33^<rd> MidWinter Research Meeting of Association for Research in Otolaryngoloty
    • Place of Presentation
      Anaheim, CA, USA
    • Year and Date
      2010-02-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Morphological Development of the Reticular Lamina in the Perinatal and Postnatal Mouse2010

    • Author(s)
      Sakaguchi H, et al.
    • Organizer
      33^<rd> MidWinter Research Meeting of Association for Research in Otolaryngoloty
    • Place of Presentation
      Anaheim, CA, USA
    • Year and Date
      2010-02-08
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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