Research Project
Grant-in-Aid for Young Scientists (B)
In the biofilm state, H.influenzae is much less susceptible to antimicrobial agents compared to the susceptibility in the planktonic state. We clearly showed the biofilm formation of clinical nontypable H.influenza (NTHi) isolates from acute otitis media(AOM) children. The current results suggest that production of biofilm by NTHi would be associated with clinical outcome of AOM. The minimal biofilm eradication concentration assay and crystal violet assay after antimicrobial exposure demonstrated that higher concentration of a certain antimicrobial agent to be effective for biofilms. The MBEC assay would be helpful for the rational selection of antimicrobial agents effective against microbial biofilms and for the screening of new effective antimicrobial compounds.
All 2010 2009
All Presentation (13 results)
