Mechanism of invasion and metastasis of thyroid papillary carcinoma with minute ossification

• Project/Area Number: 21791641
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Kitasato University
• Principal Investigator: TAKEDA Masahiko Kitasato University, 医学部, 助教 (50327417)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 甲状腺 / 乳頭癌 / 骨化 / basic fibroblast growth factor / bone morphogenic protein / 骨形成 / 血管

Research Abstract

High potential of invasion and lymph node metastasis of thyroid papillary carcinoma with minute ossification was shown. The neo-ossification was related with expression of bFGF and BMP-2. In addition, induction of neo-vascularization initiated by high expression of VEGF may resulted in vascular invasion of cancer cells.