Elucidation of mechanism and development of a new therapy against noise-induced hearing loss
| Project/Area Number |
21791642
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kobe University |
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Principal Investigator |
YAMASHITA Daisuke Kobe University, 医学部附属病院, 助教 (60306785)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 内耳 / 再生 / アポトーシス / 感音難聴 / 内耳再生 |
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| Research Abstract |
We first manufactured the animal models that became hearing loss induced by intense noise. In the hearing loss animal model, we elucidated the mechanism which led to the cell death (apoptosis) of inner hair cells. Finally, based on these results, we examined the method that hearing loss was treated by various kinds of approaches, and the results that might cure hearing loss in the both sides where were in hearing function/inner ear morphology were obtained.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] Blockage of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea.2010
Author(s)
Wakabayashi K, Fujioka M, Kanzaki S, Okano HJ, Shibata S, Yamashita D, Masuda M, Mihara M, Ohsugi Y, Ogawa K, Okano H.
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Journal Title
Neuroscience Res. 66(4)
Pages: 345-352
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