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Elucidation of mechanism and development of a new therapy against noise-induced hearing loss

Research Project

Project/Area Number 21791642
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionKobe University

Principal Investigator

YAMASHITA Daisuke  Kobe University, 医学部附属病院, 助教 (60306785)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords内耳 / 再生 / アポトーシス / 感音難聴 / 内耳再生
Research Abstract

We first manufactured the animal models that became hearing loss induced by intense noise. In the hearing loss animal model, we elucidated the mechanism which led to the cell death (apoptosis) of inner hair cells. Finally, based on these results, we examined the method that hearing loss was treated by various kinds of approaches, and the results that might cure hearing loss in the both sides where were in hearing function/inner ear morphology were obtained.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (23 results)

All 2011 2010 2009

All Journal Article (9 results) (of which Peer Reviewed: 3 results) Presentation (14 results)

  • [Journal Article] Noise-induced apoptosis in fibrocytes of the cochlear spiral limbus of mice.2011

    • Author(s)
      Cui Y, Sun G, Yamashita D, Kanzaki S, Matsunaga T, Fujii M, Kaga K, Ogawa K.
    • Journal Title

      European Arch.Oto. 268(7)

      Pages: 973-978

    • Related Report
      2010 Final Research Report
  • [Journal Article] Oral candidiasis mimicking tongue cancer.2011

    • Author(s)
      Shibata T, Yamashita D, Hasegawa S, Saito M, Otsuki N, Hashikawa K, Tahara S, Nibu K.
    • Journal Title

      Auris Nasus Larynx 38(3)

      Pages: 418-420

    • Related Report
      2010 Final Research Report
  • [Journal Article] Noise-induced apoptosis in fibrocytes of the cochlear spiral limbus of mice.2011

    • Author(s)
      Cui Y., et al.
    • Journal Title

      European Arch.Oto.

      Volume: (掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oral candidiasis mimicking tongue cancer.2011

    • Author(s)
      Shibata T., et al.
    • Journal Title

      Auris Nasus Larynx

      Volume: (掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blockage of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea.2010

    • Author(s)
      Wakabayashi K, Fujioka M, Kanzaki S, Okano HJ, Shibata S, Yamashita D, Masuda M, Mihara M, Ohsugi Y, Ogawa K, Okano H.
    • Journal Title

      Neuroscience Res. 66(4)

      Pages: 345-352

    • Related Report
      2010 Final Research Report
  • [Journal Article] 線維素性唾液管炎2010

    • Author(s)
      山下大介、丹生健一
    • Journal Title

      耳鼻咽喉科・頭頚部外科

      Volume: 82(10) Pages: 679-683

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Blockade of interleukin-6 signaling suppressed cochlea inflammatory response and improved hearing impairment in noise- damaged mice cochlea2010

    • Author(s)
      Wakabayashi K., et al.
    • Journal Title

      Neuroscience Res. 66(4)

      Pages: 345-352

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 耳鳴 特集・耳鼻咽喉科医が知っておきたい 漢方薬のイロハ2010

    • Author(s)
      齋藤晶、山下大介
    • Journal Title

      ENTONI 110

      Pages: 8-13

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 症状・症候に対する漢方治療 めまい・耳鳴り2009

    • Author(s)
      齋藤晶、山下大介
    • Journal Title

      診断と治療 97(8)

      Pages: 1541-1544

    • Related Report
      2009 Annual Research Report
  • [Presentation] Neuroprotective effects of SA4503 against noise-induced hearing loss2011

    • Author(s)
      Yamashita D., Matsunaga T., Takeshi F., Hasegawa S, Nibu K.
    • Organizer
      ARO(34回)
    • Place of Presentation
      ボルチモア(アメリカ)
    • Year and Date
      2011-02-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Neuroprotective effects of SA4503 against noise-induced hearing loss2011

    • Author(s)
      Yamashita D., et al.
    • Organizer
      Association for Research in Otolaryngology
    • Place of Presentation
      ボルチモア(アメリカ)
    • Year and Date
      2011-02-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 内耳におけるOgg1ノックアウトマウスの機能解析2010

    • Author(s)
      山下大介、神崎晶、藤田岳、長谷川信吾、丹生健一、小川郁
    • Organizer
      日本耳科学会(第20回)
    • Place of Presentation
      松山
    • Year and Date
      2010-10-07
    • Related Report
      2010 Final Research Report
  • [Presentation] 内耳における0gg1ノックアウトマウスの機能解析2010

    • Author(s)
      山下大介, 等
    • Organizer
      第20回日本耳科学会総会・学術講演会
    • Place of Presentation
      ひめぎんホール(愛媛県)
    • Year and Date
      2010-10-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 内耳移植細胞の生体内動態モニタリング法の確立2010

    • Author(s)
      山下大介、和多田有紀子、神崎晶、藤田岳、長谷川信吾、小川郁、丹生健一
    • Organizer
      自律神経研究会(第28回)
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-11
    • Related Report
      2010 Final Research Report
  • [Presentation] 内耳移植細胞の生体内動態モニタリング法の確立2010

    • Author(s)
      山下大介, 等
    • Organizer
      第28回 自律神経研究会
    • Place of Presentation
      ホテルグランヴィア(大阪府)
    • Year and Date
      2010-09-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 音響外傷性難聴に対するSA4503の内耳防御機能2010

    • Author(s)
      山下大介、松永達雄、藤田岳、長谷川信吾、丹生健一
    • Organizer
      日本耳鼻咽喉科学会総会(111回)
    • Place of Presentation
      仙台
    • Year and Date
      2010-05-22
    • Related Report
      2010 Final Research Report
  • [Presentation] 音響外傷性難聴に対するSA4503の内耳防御機能2010

    • Author(s)
      山下大介, 等
    • Organizer
      第111回 日本耳鼻咽喉科学会総会
    • Place of Presentation
      仙台国際センター(宮城県)
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 音響外傷性難聴のメカニズム解明と聴覚保護2010

    • Author(s)
      山下大介
    • Organizer
      サウンド財団研究助成講演会
    • Place of Presentation
      浜松
    • Year and Date
      2010-02-15
    • Related Report
      2010 Final Research Report
  • [Presentation] 音響外傷性難聴のメカニズム解明と聴覚保護2010

    • Author(s)
      山下大介
    • Organizer
      財団法入サウンド技術振興財団第21回研究助成講演会
    • Place of Presentation
      アクトシディ浜松(静岡県)
    • Year and Date
      2010-02-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] Detection system for transplanted bone marrow stem cells in inner ear by SPIO2010

    • Author(s)
      Yamashita D., Watada Y., Kanzaki S., Hasegawa S, Nibu K., Ogawa K.
    • Organizer
      ARO(33回)
    • Place of Presentation
      アナハイム(アメリカ)
    • Year and Date
      2010-02-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Detection System for Transplanted Bone Marrow Stem Cells in Inner Ear by SPIO2010

    • Author(s)
      Yamashita D., et al.
    • Organizer
      Association for Research in Otolaryngology
    • Place of Presentation
      アメリカ、カリフォルニア
    • Year and Date
      2010-02-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] 内耳移植細胞の生体内動態モニタリング法の確立2009

    • Author(s)
      山下大介、和多田有紀子、神崎晶、長谷川信吾、丹生健一、小川郁
    • Organizer
      日本耳科学会(第19回)
    • Place of Presentation
      東京
    • Year and Date
      2009-10-07
    • Related Report
      2010 Final Research Report
  • [Presentation] 内耳移植細胞の生体内動態モニタリング法の確立2009

    • Author(s)
      山下大介, 等
    • Organizer
      第19回日本耳科学会総会・学術講演会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2009-10-07
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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